MG 101 (Alternative Name: Calpain inhibitor-1 N-Acetyl-L-leucine-L-leucine-L-norleucinal) | 110044-82-1

name

mg 101

chemical name

alternative name: calpain inhibitor-1 n-acetyl-l-leucine-l-leucine-l-norleucinal

activity

calpain inhibitor (ic50 = 0.09 μm) that activates p53-dependent apoptosis in tumor cell lines. increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin d degradation in vitro. also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of inos and cox-2 expression.

MW

383.53

Formula:

c20h37n3o4

Solubility:

soluble to 50 mm in dmso and to 25 mm in ethanol

Storage:

store at -20°c

CAS No:

110044-82-1

Sherwood et al (1993) In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc.Natl.Acad.Sci.USA 90 3353.

Atencio et al (2000) Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines. Cell Growth Differ. 11 247. PMID: 10845425.

Chatterjee et al (2001) Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59 2073. PMID: 11380809.

Perrin et al (2002) In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cell Mol.Biol. 48 OL267.