PHA 543613 hydrochloride (N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride) | 478149-53-0

name

pha 543613 hydrochloride

chemical name

n-(3r)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride

activity

potent α7 nachr agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-ht3 receptors. positively influences sensory gating and memory in in vivo models of schizophrenia. orally active and brain penetrant.

MW

307.78

Formula:

c15h17n3o2.hcl

Solubility:

soluble to 100 mm in water and to 25 mm in dmso

Purity:

>98 %

Storage:

store at +4°c

CAS No:

478149-53-0

Wishka et al (2006) Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia; synthesis and structure-activity relationship. J.Med.Chem. 49 4425. PMID: 16821801.

Acker et al (2008) Discovery of N-[3R,5R)-1-azabicyclo[3.2.1]ocy-3-yl]furo-[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: in vitro and in vivo activity. Bioorg.Med.Chem.Letts. 18 3611.

Faghih et al (2008) Allosteric modulators of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 51 701. PMID: 18198823.