Tautomycetin | 119757-73-2

name

tautomycetin

chemical name

(1r,2s,3r,6s,7s,10s,12r,15e,βr,3r)-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester

activity

selective inhibitor of protein phosphatase (pp)1 (ic50 values are 1.6 and 62 nm for pp1 and pp2 respectively). reduces pdgf-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. immunosuppressive agent; inhibits proliferation and induces apoptosis in activated t cells.

MW

606.75

Formula:

c33h50o10

Solubility:

soluble in dmso (supplied pre-dissolved in dmso, 10mg/ml)

Purity:

>95 %

Storage:

desiccate at -20°c

CAS No:

119757-73-2

Mitsuhashi et al (2001) Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochem.Biophys.Res.Comm. 287 328. PMID: 11554729.

Shim et al (2002) Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc.Natl.Acad.Sci.USA. 99 10617. PMID: 12149481.

Kim et al (2005) Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. Transplant Proc. 37 1959. PMID: 15919517.