Amisulpride (Alternative Name: DAN 2163 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide) | 71675-85-9

name

amisulpride

chemical name

alternative name: dan 2163 4-amino-n-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide

activity

potent, selective dopamine d2 and d3 receptor antagonist. ki values are 2.8 and 3.2 nm respectively for human d2 and d3 and > 1000 nm for human d1, d4 and d5 receptors. shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic d2/d3 receptors at higher doses. preferentially interacts with limbic d2-like receptors in vivo. atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.

MW

369.48

Formula:

c17h27n3o4s

Solubility:

soluble to 25 mm in 1eq. hcl with gentle warming and to 50 mm in dmso

Purity:

>98 %

Storage:

store at -20°c

CAS No:

71675-85-9

Perrault et al (1997) Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D₂/D₃ dopamine receptor antagonist activity and limbic selectivity. J.Pharmacol.Exp.Ther. 280 73. PMID: 8996184.

Schoemaker et al (1997) Neurochemical characteristics of amisulpride, an atypical dopamine D₂/D₃ receptor antagonist with both presynaptic and limbic selectivity. J.Pharmacol.Exp.Ther. 280 83. PMID: 8996185.

Moller (2003) Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog.Neuro-Psychopharm.Biol.Psychiat. 27 1101.