2-Methoxyestradiol ((17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol) | 362-07-2

name

2-methoxyestradiol

chemical name

(17β)-2-methoxyestra-1,3,5(10)-triene-3,17-diol

activity

apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo; acts via an estrogen receptor-independent mechanism. induces p53-induced apoptosis via two pathways: activation of p38 and nf-κb; and activation of jnk and ap-1 leading to bcl-2 phosphorylation. also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

MW

302.41

Formula:

c19h26o3

Solubility:

soluble to 50 mm in dmso

Purity:

>99 %

Storage:

store at rt

CAS No:

362-07-2

D'Amato et al (1994) 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc.Natl.Acad.Sci.U.S.A. 91 3964. PMID: 8171020.

LaVallee et al (2002) 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res. 62 3691. PMID: 12097276.

LaVallee et al (2003) 2-Methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 63 468. PMID: 12543804.

Shimada et al (2003) Roles of p38 and c-jun NH₂-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24 1067. PMID: 12807754.