(+)-AJ 76 hydrochloride ((1S,2R)-cis-5-Methoxy-1-methyl-2-(N-propylamino)tetralin hydrochloride) | 85378-82-1

name

(+)-aj 76 hydrochloride

chemical name

(1s,2r)-cis-5-methoxy-1-methyl-2-(n-propylamino)tetralin hydrochloride

activity

dopamine receptor antagonist with preferential action at presynaptic receptors (pki values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hd3. hd4, hd2s, hd2l and rd2 receptors respectively).

MW

269.81

Formula:

c15h23no.hcl

Solubility:

soluble to 10 mm in water

Storage:

store at rt

CAS No:

85378-82-1

Johansson et al (1987) Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists. J.Med.Chem. 30 602. PMID: 3560156.

Kullingsjo et al (1991) Effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur.J.Pharmacol. 205 241. PMID: 1817961.

Waters et al (1994) Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo. Eur.J.Pharmacol. 251 181. PMID: 8149975.

Millan et al (2004) The role of dopamine D₃ compared with dopamine D₂ receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 174 341. PMID: 14985929.