Animal-Free Recombinant Human SDF-1α (CXCL12)

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• 製品詳細
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価格

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製品詳細

name	Animal-Free Recombinant Human SDF-1α (CXCL12)
Source	E.coli
Synonyms	Stromal-Cell Derived Factor-1, CXCL12, PBSF
AA Sequence	KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentation of 20-80 ng/ml.
Description	SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Human SDF-1α is an 8.0 kDa protein containing 68 amino acid residues.
Cross Reactivity	Human, Mouse

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文献

1. First Author:Hyduk, S J
   Title:Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation.
   Citation:Journal of Immunology; 187(8):4360-8
   
2. First Author:Nasser, M W
   Title:Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion.
   Citation:PLoS ONE; 6(9):e23901
   
3. First Author:Munk, R
   Title:Involvement of mTOR in CXCL12 mediated T cell signaling and migration.
   Citation:PLoS ONE; 6(9):e24667
   
4. First Author:Freeley, M
   Title:L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes.
   Citation:The Journal of Immunology; 188(12):6357-70
   
5. First Author:Trachtenberg, A
   Title:The level of CD147 expression correlates with cyclophilin-induced signalling and chemotaxis.
   Citation:BMC Research Notes; 4:396
   
6. First Author:Saini, V
   Title:Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction.
   Citation:The Journal of Biological Chemistry; 286(51):44145-52
   
7. First Author:Schaeuble, K
   Title:Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration.
   Citation:The Journal of Immunology; 187(11):5645-52
   
8. First Author:Yang, D
   Title:High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
   Citation:The Journal of Experimental Medicine; 209(1):157-71
   
9. First Author:O'Callaghan, K
   Title:Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia.
   Citation:Blood; 119(7):1717-25
   
10. First Author:Chenivesse, C
    Title:Pulmonary CCL18 Recruits Human Regulatory T Cells.
    Citation:The Journal of Immunology; 189(1):128-37
    

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