Animal-Free Recombinant Human IL-2

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• 製品詳細
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価格

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製品詳細

name	Animal-Free Recombinant Human IL-2
Source	E.coli
Synonyms	T-cell growth factor (TCGF), Aldesleukin
AA Sequence	MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Description	IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.  IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response.  IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.  Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.
Cross Reactivity	Bacteria, Cow, Cow + Mouse, Dog, Human, Human + Mouse, Leech, Monkey, Mouse, Rat

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文献

1. First Author:Fowler, D W
   Title:Mycobacteria activate γσ T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.
   Citation:Cancer Immunology and Immunotherapy; 61(4):535-47
   
2. First Author:Tsuda, K
   Title:Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.
   Citation:PLoS ONE; 7(2):e31465
   
3. First Author:Kunisawa, J
   Title:A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo.
   Citation:PLoS ONE; 7(2):e32094
   
4. First Author:Lv, L H
   Title:Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro.
   Citation:The Journal of Biological Chemistry; 287(19):15874-85
   
5. First Author:Munir, S
   Title:Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase.
   Citation:PLoS ONE; 7(4):e34568
   
6. First Author:Schilling, B
   Title:IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model.
   Citation:Journal of Molecular Medicine; 90(2):139-47
   
7. First Author:Zhou, R
   Title:A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid.
   Citation:Journal of Immunology; 187(8):4170-7
   
8. First Author:Lu, J
   Title:Human ovarian tumor cells escape ?d T cell recognition partly by down regulating surface expression of MICA and limiting cell cycle related molecules.
   Citation:PLoS ONE; 6(9):e23348
   
9. First Author:Grangeiro de Carvalho, E
   Title:Plasmodium falciparum-infected erythrocytes and IL-12/IL-18 induce diverse transcriptomes in human NK cells: IFN-a/ß pathway versus TREM signaling.
   Citation:PLoS ONE; 6(9):e24963
   
10. First Author:Kim, T D
    Title:Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity.
    Citation:Blood; 118(20):5476-86
    

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