抗CTLA4 [BNI3] (PE)抗体 | Anti-CTLA4 [BNI3] (PE) antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	BNI3
Isotype	IgG2a
Application	FACS
Reactivity	Human, Mouse

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
FACS	Neat
Note : FACS Membrane permeabilisation is required for this application. Use 20μl of the suggested working dilution to label 5 x 105 cells in 100μl.

Not tested in other applications.

Calculated MW	25 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS, 0.1% Sodium Azide, 2% BSA
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Human CTLA-4/human IgG heavy chain fusion protein.
Purification	Protein A purified
Conjugation	Phycoerythrin (PE)
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Cytotoxic T-Lymphocyte Associated Protein 4 , Alps5 , Cd , Cd152 , Celiac3 , Ctla-4 , Grd4 , Gse , Iddm12 , Ctla4
Background	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 1493 ・ UniProt: P16410

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Zhao Y et al. Biomed Pharmacother 2017; 90 : 147-152 Enhance the anti-renca carcinoma effect of a DNA vaccine targeting G250 gene by co-expression with cytotoxic T-lymphocyte associated antigen-4(CTLA-4).	Application : FACS Reactivity : Mouse

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