抗Serotonin [5-HT-H209]抗体 | Anti-Serotonin [5-HT-H209] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

IHC-P analysis of human appendix tissue using GTX31099 Serotonin antibody [5-HT-H209].

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	5HT-H209
Isotype	IgG1
Application	ICC/IF, IHC-P, IHC-Fr, IHC
Reactivity	Human, Mouse, Chicken, Pig, Rhesus Monkey

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
ICC/IF	1:50
IHC-P	1:50 - 1:100
IHC-Fr	1:50 - 1:100
IHC	Assay dependent

Not tested in other applications.

Specificity/Sensitivity

Reacts with serotonin in a broad range of normal, hyperplastic and neoplastic tissues. Serotonin is also called 5-hydroxytryptamine. The antibody is of particular importance in identifying primary and metastatic carcinoid tumors expressing serotonin. This antibody may be a useful tool for characterization of carcinoids. In a study of 48 cases of adenomas and carcinoid tumours of the middle ear, the labelled tumour cells in 12 cases (25%).

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PROPERTIES

Form	Liquid
Buffer	Tissue culture supernatant dialysed against 0.05 mol/L Tris/HCl pH 7.2, 0.09% Sodium Azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Immunogen	5-Hydroxytryptamine hydrochloride (3-(2-aminoethyl)-5-hydroxyindole;serotonin).
Purification	Unpurified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Background	Serotonin-positive cells are present in gastric, duodenal, jejunal, ileal, colonic, and appendiceal mucosae. Positive cells are sparse and usually occur in the lower half of the gastric and intestinal mucosae. In the appendix, in addition to the mucosal serotonin-containing cells, there are single or small clusters of serotonin-positive cells in the sub-epithelial region of the lamina propria.

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Brokhman I et al. Dev Biol 2019; 445 (2) : 256-270 Dual embryonic origin of the mammalian enteric nervous system.
Eggermont M et al. Anat Rec (Hoboken) 2018; (Epub) Regional structural and functional specialisations in the urethra of the female rat: evidence for complex physiological control systems.	Application : IHC-Fr
Iwata K et al. Mol Autism 2014; 5 : 33 N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism.	Application : ICC/IF
Vela Hinojosa C et al. PLoS One 2013; 8 (9) : e75062 Differential expression of serotonin, tryptophan hydroxylase and monoamine oxidase A in the mammary gland of the Myotis velifer bat.	Application : IHC-Fr
Becnel J et al. PLoS One 2011; 6 (6):e20800 The serotonin 5-HT7Dro receptor is expressed in the brain of Drosophila, and is essential for normal courtship and mating.	Application : IHC

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