抗Fas抗体 | Anti-Fas antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-P, IHC-Fr
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

For Western Blotting, use at a dilution of 1:100 Optimal dilutions should be determined by the user.

Calculated MW	37 kDa. ( Note )
Positive Control	K562 and HL-60 lysate.

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PROPERTIES

Form	Liquid
Buffer	Preservative: 0.1% Sodium Azide; Constituents: 0.2% Gelatin, PBS
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Rat
Immunogen	Synthetic peptide (Rat) (N terminal).
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Fas Cell Surface Death Receptor , Tnfrsf6 , Fas
Cellular Localization	Plasma membrane
Background	Fas / APO-1 (CD95) is an important member of the tumor necrosis factor (TNF) superfamily involved in membrane-mediated apoptosis. Ligation of Fas by Fas Ligand (Fas-L) or an anti-Fas cross-linking antibody, triggers activation of the caspase cascade (1). Functional impairment of the Fas / Fas-L system is associated with the development and progression of malignancies (2). Fas gene mutations have been suggested to have a role in testicular germ cell tumors (3). Tumor cells frequently exhibit de novo expression of Fas Ligand (Fas-L), which plays a significant role in local tissue destruction, metastatic spread, and immune escape of the tumor cells (8). The apoptosis of lymphocytes, which occurs in autoimmune diseases, is usually induced by the Fas/Fas-L system (7). Fas is believed to be involved in various autoimmune diseases including, ulcerative colitis, Graves disease, and rheumatoid arthritis (5,7). Fas expression on gastric epithelial cells in patients infected with H. Pylori is responsible for the accelerated apoptosis of the cells (4). Serum Fas-L concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension (6).
Database	・ Gene ID: 246097 ・ UniProt: Q63199

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