抗APC [CC-1]抗体 | Anti-APC [CC-1] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

目次に戻る

価格

目次に戻る

製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	CC-1
Isotype	IgG2b
Application	ICC/IF, IHC-P, IHC-Fr, IHC (Free Floating)
Reactivity	Human, Mouse, Rat

目次に戻る

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
ICC/IF	5 μg/ml
IHC-P	5 μg/ml
IHC-Fr	5 μg/ml
IHC (Free Floating)	Assay dependent
Note : IHC-P Heat pre-treament required

Not tested in other applications.

Calculated MW	312 kDa. ( Note )
Specificity/Sensitivity	This antibody has been shown to detect oligodendrocytes and astrocytes.

目次に戻る

PROPERTIES

Form	Liquid
Buffer	0.2% Gelatin, 50mM Sodium phosphate with 0.1% sodium azide as a preservative
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	A recombinant protein consisting of amino acids 1-226 of APC.
Purification	Affinity purified with antigen
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

目次に戻る

TARGET

Synonyms	Apc, Wnt Signaling Pathway Regulator , Btps2 , Dp2 , Dp2.5 , Dp3 , Gs , Ppp1R46 , Apc
Cellular Localization	Secreted
Background	This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 324 APC ・ UniProt: P25054 APC

目次に戻る

REFERENCEE(抜粋)

Application Reference	Application/Reactivity
G?ttle P et al. Glia 2019; 67 (1) : 160-170 Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination.	Application : ICC/IF Reactivity : Rat
Jadasz JJ et al. Glia 2017; (Epub) Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.	Application : IHC-Fr Reactivity : Rat
Gottle P et al. J Neurosci 2015; 35 (3) : 906-19 Oligodendroglial maturation is dependent on intracellular protein shuttling.	Application : ICC/IF Reactivity : Rat
Matsuyama D et al. Spinal Cord 2014; 52 (1) : 43359 Endoplasmic reticulum stress response in the rat contusive spinal cord injury model-susceptibility in specific cell types.	Application : IHC-Fr Reactivity : Rat
Moore S et al. J Neurosci Res 2014; Restoration of axon conduction and motor deficits by therapeutic treatment with * acetate.	Application : IHC-P Reactivity : Mouse

目次に戻る