GDF-15 組換え体(リコンビナント)タンパク質 | Recombinant Human GDF-15
掲載日情報:2015/01/26 現在Webページ番号:113293
R&D Systems社製の高品質なGDF-15の組換え体タンパク質(Recombinant Human GDF-15)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2025年04月26日 10時15分現在]
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GDF-15, Human, Recombinant <MIC-1> |
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GDF-15/MIC-1, Human, Recombinant, Carrier-free |
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[在庫・価格 :2025年04月26日 10時15分現在]
GDF-15, Human, Recombinant <MIC-1>
文献数: 22
- 商品コード:957-GD-025
- メーカー:RSD
- 包装:25μg
- 価格:¥89,000
- 在庫:1個
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 産生:CHO,純度:>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Human,M.W.:13 kDa (monomer),Genbank:9518,エンドトキシンレベル:<1.0 EU per 1 µg of the protein by the LAL method. 別名:GDF15 Genbank No: 9518 Protein Accession No: Q99988 |
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保存条件 | -20℃ | 法規備考 | |
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GDF-15/MIC-1, Human, Recombinant, Carrier-free
文献数: 0
- 商品コード:957-GD-025/CF
- メーカー:RSD
- 包装:25μg
- 価格:¥89,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 産生:CHO,純度:>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Human,M.W.:13 kDa (monomer),Genbank:9518,エンドトキシンレベル:<1.0 EU per 1 µg of the protein by the LAL method. 別名:GDF15 Genbank No: 9518 Protein Accession No: Q99988 |
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法規制等 | |||
保存条件 | -20℃ | 法規備考 | |
掲載カタログ |
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製品記事 | |||
関連記事 |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
追加しました。
CF(Carrier-Free)とは?
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Chinese Hamster Ovary cell line, CHO-derived, Ala197-Ile308, with an N-terminal 6-His tag
- Accession
- Q99988
- Structure
- Disulfide-linked homodimer
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 13 kDa (monomer). Based on mass spectrometric analysis, a carboxyl-terminal truncated peptide with a molecular mass of approximately 12.5 kDa is also present in the recombinant protein preparation.
- SDS-PAGE
- 14 kDa, reducing conditions
- Activity
- Bioassay data are not available.The ED50 for this effect is typically 25 - 50 ng/mL in the presence of 0.1 µg/mL heparin.
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Additional Information
- Molecule Information
- GDF-15
- Aliases
- MIC-1; NAG-1; PDF; PLAB; PTGF-beta
- Entrez Gene IDs
- 9518 (Human); 23886 (Mouse); 29455 (Rat)
- Background
- Growth/Differentiation Factors (GDFs)
- Growth/differentiation factors (GDF-1 to GDF-15) are members of the BMP family of TGF-beta superfamily proteins. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and -9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
GDF-15 prevents platelet integrin activation and thrombus formation.
Rossaint J, Vestweber D, Zarbock A
J Thromb Haemost 2013 11:335-44
Species: Mouse
Protein Application: Bioassay
Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors.
Arnold B, Demory A, Dietz L, Geraud C, Goerdt S, Gratchev A, Grone HJ, Kempf T, Kzhyshkowska J, Schirmacher P, Schledzewski K, Schonhaber H, Straub BK, Thierse HJ, Wang S, Wollert KC
J. Clin. Invest. 2011 121:703-14
Species: Mouse
Protein Application: Bioassay
Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes.
Cheng M, Gong Q, Liu X, Si Y, Wang M, Wang T, Yang W, Yang Y
PLoS ONE 2011 6:e19967
Species: Human
Protein Application: Bioassay
Wild-type p53 attenuates cancer cell motility by inducing growth differentiation factor-15 expression.
Chang HM, Cheng JC, Leung PC
Endocrinology 2011 152:2987-95
Species: Human
Protein Application: Bioassay
Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
Castonguay R, Grinberg AV, Kumar R, Matthews RG, Mulivor AW, Pearsall RS, Presman E, Sako D, Seehra J, Solban N, Underwood KW, Werner ED
J. Biol. Chem. 2011 286:30034-46
Species: Human
Protein Application: Surface Plasmon Resonance
Macrophage inhibitory cytokine-1 regulates melanoma vascular development.
Chung CY, Huh SJ, Sharma A
Am. J. Pathol. 2010 176:2948-57
Species: Chicken
Protein Application: In Vivo
Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes.
Bing C, Ding Q, Gonzalez-Muniesa P, Kos K, Mracek T, Trayhurn P, Wilding J
Endocrinology 2009 150:1688-96
Species: Human
Protein Application: Bioassay
Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction.
Davies JE, Dhillon O, Kelly D, Khan SQ, Ng K, Ng LL, Quinn P, Squire IB
Eur. Heart J. 2009 30:1057-65
Species: N/A
Protein Application: ELISA Standard
Progressive postnatal motoneuron loss in mice lacking GDF-15.
Altick AL, Bendner G, Diella F, Klein R, Rusu P, Sendtner M, Strelau J, Strzelczyk A, Unsicker K, von Bartheld CS, Wiese S
J. Neurosci. 2009 29:13640-8
Species: Mouse
Protein Application: Bioassay
Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy.
Foley PW, Frenneaux MP, Leyva F, Ng K, Ng LL, Proudler A, Ramachandran S, Stegemann B
Eur. Heart J. 2009 30:2749-57
Species: N/A
Protein Application: ELISA Standard
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