E-Selectin/CD62E Fc Chimera 組換え体(リコンビナント)タンパク質 | Recombinant Human E-Selectin/CD62E Fc Chimera
掲載日情報：2015/01/26 現在Webページ番号：113147
R&D Systems社製の高品質なE-Selectin/CD62E Fc Chimeraの組換え体タンパク質(Recombinant Human E-Selectin/CD62E Fc Chimera)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月29日 10時55分現在]
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[在庫・価格 ：2025年04月29日 10時55分現在]
E-Selectin/Fc Chimera, Human, Recombinant
文献数： 26
- 商品コード：724-ES-100
- メーカー：RSD
- 包装：100μg
- 価格：¥86,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：NS0，純度：>95%, by SDS-PAGE under reducing conditions and visualized by silver stain，由来動物：Human，M.W.：86 kDa (monomer)，Genbank：6401，エンドトキシンレベル：<0.1 EU per 1 µg of the protein by the LAL method. 別名：CD62 antigen-like family member E Genbank No： 6401 Protein Accession No： P16581 |
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| 保存条件 | -20℃ | 法規備考 | |
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| 製品記事 | R&D Systems社 E-Selectin関連製品 |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived
- Accession
- P16581
- Structure
- Disulfide-linked homodimer
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 86 kDa (monomer)
- SDS-PAGE
- 150 kDa, reducing conditions
- Activity
- Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells.When 5 x 104 cells/well are added to human E-Selectin/Fc Chimera coated plates (2 µg/mL with 100 µL/well), approximately 90 - 100% will adhere after 1 hour incubation at RT. Optimal dilutions should be determined by each laboratory for each application.
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Additional Information
- Molecule Information
- E-Selectin/CD62E
- Aliases
- CD62E; ELAM1; LECAM2; SELE
- Entrez Gene IDs
- 6401 (Human); 20339 (Mouse); 25544 (Rat)
- Background
- Selectins
- The Selectin family is comprised of three members, E-Selectin, L-Selectin, and P-Selectin. E-Selectin [endothelial leukocyte adhesion molecule-1 (ELAM-1), CD62E] is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha. The human and rat proteins share approximately 67% amino acid sequence identity. The mouse and rat proteins share approximately 78% amino acid sequence identity. L-Selectin (Leukocyte Selectin, LAM-1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L) is expressed constitutively on a wide variety of leukocytes. Two forms of L-Selectin have been reported, apparently arising as a result of post-translational modifications. Human and mouse L-Selectin share 76% amino acid sequence identity. Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P) is expressed by activated platelets and endothelial cells. The extracellular domains of human and mouse P-Selectin share approximately 73% amino acid sequence identity.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFkappaB survival axis downstream of Death receptor-3.
Auger FA, Gout S, Houle F, Huot J, Klinck R, Paquet ER, Pin AL, Poirier A, Porquet N, Tremblay PL
BMC Cancer 2011 11:285
Species: Human
Protein Application: Bioassay
The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion.
Kato N, Kosugi T, Yuzawa Y
J. Am. Soc. Nephrol. 2009 20:1565-76
Species: Mouse
Protein Application: Binding Assay
CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.
Ando H, Fujimoto J, Furukawa Y, Kanamori A, Kannagi R, Kikuchi J, Kiyokawa N, Mitsunaga K, Muroi K, Nakamura M, Nonomura C, Ozaki H
Cancer Res. 2008 68:790-9
Species: Human
Protein Application: Flow Cytometry
Varied levels of reactivity by different E-selectin/Fc constructs with cutaneous lymphocyte-associated antigen (CLA)(+) CD4(+) T cells.
Ni Z, NiZh ZImmunol. Lett. 2007 108:179-82Species: HumanProtein Application: Bioassay
Immunol. Lett. 2007 108:179-82
Species: Human
Protein Application: Bioassay
The monoclonal antibody CHO-131 identifies a subset of cutaneous lymphocyte-associated antigen T cells enriched in P-selectin-binding cells.
Campbell JJ, Ni Z, Niehans G, Walcheck B
J. Immunol. 2006 177:4742-8
Species: Human
Protein Application: Flow Cytometry
The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors.
Clark RA, Fuhlbrigge RC, Hirahara K, Kupper TS, Liu L, Yamanaka K
J. Immunol. 2006 177:4488-94
Species: Human
Protein Application: Bioassay
In vitro differentiation from naive to mature E-selectin binding CD4 T cells: acquisition of skin-homing properties occurs independently of cutaneous lymphocyte antigen expression.
Hayakawa J, Hayakawa K, Kudo A, Mizukawa Y, Shiohara T, Takahashi R, Yamazaki Y
J. Immunol. 2003 171:5769-77
Species: Human
Protein Application: Flow Cytometry
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