ICAM-1/CD54 Fc Chimera 組換え体(リコンビナント)タンパク質 | Recombinant Human ICAM-1/CD54 Fc Chimera
掲載日情報：2015/01/26 現在Webページ番号：113144
R&D Systems社製の高品質なICAM-1/CD54 Fc Chimeraの組換え体タンパク質(Recombinant Human ICAM-1/CD54 Fc Chimera)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年05月01日 12時15分現在]
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ICAM-1/Fc Chimera, Human, Recombinant <CD54> |
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[在庫・価格 ：2025年05月01日 12時15分現在]
ICAM-1/Fc Chimera, Human, Recombinant <CD54>
文献数： 50
- 商品コード：720-IC-200
- メーカー：RSD
- 包装：200μg
- 価格：¥173,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：NS0，純度：>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：76 kDa (monomer)，Genbank：3383，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：BB2 Genbank No： 3383 Protein Accession No： CAA30051 |
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| 保存条件 | -20℃ | 法規備考 | |||||
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived
- Accession
- CAA30051
- Structure
- Disulfide-linked homodimer
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 76 kDa (monomer)
- SDS-PAGE
- 110-125 kDa, reducing conditions
- Activity
- Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.When 5 x 104 cells/well are added to recombinant human ICAM Fc Chimera coated plates (12.5 µg/mL with 100 µL/well), >60% will adhere after PMA 1 hour incubation at 37 °C.Optimal dilutions should be determined by each laboratory for each application.
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Additional Information
- Molecule Information
- ICAM-1/CD54
- Aliases
- CD54
- Entrez Gene IDs
- 3383 (Human); 15894 (Mouse); 25464 (Rat)
- Background
- ICAM-1/CD54
- Intercellular adhesion molecule 1 (ICAM-1), also known as CD54, binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1 beta and LPS. Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-beta signaling.
Barry S, Davies A, Dempsey E, Fallon P, Kelleher D, Long A, Verma N, Volkov Y
J Biol Chem 2012 287:27204-16
Species: Human
Protein Application: Bioassay
Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
Eur J Immunol 2012 42:2142-51
Epstein-Barr virus infection of polarized epithelial cells via the basolateral surface by memory B cell-mediated transfer infection.
Rowe M, Shannon-Lowe C
PLoS Pathog. 2011 7:e1001338
Species: Human
Protein Application: Adhesion Assay
CD29 expressed on plasma cells is activated by divalent cations and soluble CD106 contained in the bone marrow plasma: refractory activation is associated with enhanced proliferation and exit of clonal plasma cells to circulation in multiple myeloma patients.
Coll J, Garcia-Trujillo JA, Martinez-Vinambres E, Rodriguez-Martin E, Roldan E, Villar LM
Leukemia 2011 26:1098-105
Species: Human
Protein Application: Bioassay
A mechanism for antibody-mediated outside-in activation of LFA-1.
Carreno R, Legge GB, Li D, Ma Q, Nira I, Sen M, Yamakawa T
J. Biol. Chem. 2008 283:10642-8
Species: Human
Protein Application: Surface Plasmon Resonance
JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.
Bourdoulous S, Calderwood DA, Couraud PO, Luissint AC, Lutz PG
J. Cell Biol. 2008 183:1159-73
Species: Human
Protein Application: Bioassay
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces.
Alon R, Cyster JG, Feigelson SW, Grabovsky V, Grigorova I, Hartmann T, Sagiv A, Shulman Z, Sixt M, Woolf E
Nat. Immunol. 2007 8:1076-85
Species: Human
Protein Application: Bioassay
Activation of CR3-mediated phagocytosis by MSP requires the RON receptor, tyrosine kinase activity, phosphatidylinositol 3-kinase, and protein kinase C zeta.
Correll PH, Lutz MA
J. Leukoc. Biol. 2003 73:802-14
Species: Human
Protein Application: Flow Cytometry
CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells.
Carroll VA, Hwang ST, Knibbs RN, Maki W, Morales RE, Stoolman LM, Telford WG
J. Immunol. 2002 169:2346-53
Species: Human
Protein Application: Bioassay
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