Wnt-5a 組換え体(リコンビナント)タンパク質 | Recombinant Human/Mouse Wnt-5a
掲載日情報：2015/01/26 現在Webページ番号：113083
R&D Systems社製の高品質なWnt-5aの組換え体タンパク質(Recombinant Human/Mouse Wnt-5a)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月26日 19時15分現在]
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[在庫・価格 ：2025年04月26日 19時15分現在]
Wnt-5A, Human/Mouse, Recombinant
文献数： 86
- 商品コード：645-WN-010
- メーカー：RSD
- 包装：10μg
- 価格：¥138,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：CHO，純度：>80%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human, Mouse，M.W.：38 kDa，Genbank：7474，エンドトキシンレベル：<1.0 EU per 1 µg of the protein by the LAL method. 別名：hWNT5A Genbank No： 7474 Protein Accession No： P22725 |
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| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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| 製品記事 | R&D Systems 社 Wnt-5a関連製品 Wnt関連製品 |
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Wnt-5A, Human/Mouse, Recombinant, Carrier-free
文献数： 0
- 商品コード：645-WN-010/CF
- メーカー：RSD
- 包装：10μg
- 価格：¥138,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：CHO，純度：>80%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human, Mouse，M.W.：38 kDa，Genbank：7474，エンドトキシンレベル：<1.0 EU per 1 µg of the protein by the LAL method. 別名：hWNT5A Genbank No： 7474 Protein Accession No： P22725 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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| 製品記事 | R&D Systems 社 Wnt-5a関連製品 Wnt関連製品 |
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| 関連記事 | |||
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
追加しました。
CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Chinese Hamster Ovary cell line, CHO-derived, Gln38-Lys380
- Accession
- P22725
- Purity
- >80%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 38 kDa
- SDS-PAGE
- 45 kDa, reducing conditions
- Activity
- Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells.The ED50 for this effect is typically 0.1-0.5 µg/mL, in the presence of 5 ng/mL rmWnt-3a. Optimal concentrations should be determined by each laboratory for each application.
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Additional Information
- Molecule Information
- Wnt-5a
- Aliases
- undefined
- Entrez Gene IDs
- 7474 (Human); 22418 (Mouse)
- Background
- Wnt-5a
- Wnt proteins are secreted glycoproteins that play critical roles in both carcinogenesis and embryonic development for a variety of organisms. Wnt-5a is part of the subgroup of Wnts that are not axis-inducing in Xenopus embryos and do not transform C57MG mammary epithelial cells. This subgroup is also implicated in the Wnt/Ca2+ pathway, playing roles in cell movements and cell adhesion. This non-canonical Wnt pathway can inhibit canonical Wnt/beta-catenin signaling. In Wnt-5a deficient mouse embryos, beta-catenin accumulates in the limb bud suggesting that Wnt-5a normally promotes degradation of beta-catenin.Likewise, in Xenopus embryos Wnt-5a antagonizes the ability of the canonical Wnt subgroup to induce a secondary axis.Wnt-5a is implicated in various types of cancer and has complex roles. Wnt-5a is known to act as a tumor suppressor for mammary, B-cell, colon, and uroepithelial cancer cells. In contrast, Wnt-5a is upregulated in melanomas, where expression levels correlate with severity of metastasis. Furthermore, aberrant Wnt-5a signaling results in other diseases such as rheumatoid arthritis.Like other developmental growth factors Wnt-5a has diverse roles in development which range from early anterior-posterior development and gastrulation movements to maintaining hematopoietic stem cell population, lung morphogenesis, and limb outgrowth. Mouse and human Wnt-5a share 97% amino acid identity.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex.
J. Cell. Sci. 2102 125:2017-29
Species: Mouse
Protein Application: Bioassay
Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.
Chin EN, Fakhraldeen SA, Goel S
J. Biol. Chem. 2012 287:16454-66
Species: Mouse
Protein Application: Bioassay
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Burton L, Chan E, Fridlyand J, Koeppen H, Li J, Lin E, Merchant M, Moffat J, Neve R, Peng J, Penuel E, Ribas A, Settleman J, Sosman J, Sutherlin DP, Wang Y, Wilson TR, Yan Y
Nature 2012 487:505-9
Species: Human
Protein Application: Bioassay
Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the beta-catenin destruction complex.
Polakis P, Tran H
J Biol Chem 2012 287:28552-63
Species: Human
Protein Application: Bioassay
Wnt5a and Wnt11 are essential for second heart field progenitor development.
Cohen E, Miller M, Moon R, Morrisey E, Wang Z
Development 2012 139:1931-40
WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
Bryja V, Dijksterhuis JP, Ganji RS, Kilander MB, Schulte G
Cell. Signal. 2011 23:550-4
Species: Human
Protein Application: Bioassay
Wnt5a regulates midbrain dopaminergic axon growth and guidance.
Blakely BD, Bye CR, Fernando CV
PLoS ONE 2011 6:e18373
Species: Rat
Protein Application: Bioassay
WNT5A Signaling Contributes to Abeta-Induced Neuroinflammation and Neurotoxicity.
Andersson T, Huang M, Li B, Tang SJ, Yang X, Zhong L
PLoS ONE 2011 6:e22920
Species: Mouse
Protein Application: Bioassay
Evidence for altered Wnt signaling in psoriatic skin.
Gudjonsson JE, Johnston A, Stoll SW
J. Invest. Dermatol. 2010 130:1849-59
Species: Human
The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma.
Fiori JL, O'Connell MP, Xu M
Oncogene 2010 29:34-44
Species: Human
Protein Application: Bioassay
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