VEGF-D 組換え体(リコンビナント)タンパク質 | Recombinant Human VEGF-D
掲載日情報:2015/01/26 現在Webページ番号:113066
R&D Systems社製の高品質なVEGF-Dの組換え体タンパク質(Recombinant Human VEGF-D)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2024年06月08日 20時55分現在]
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[在庫・価格 :2024年06月08日 20時55分現在]
VEGF-D, Human, Recombinant <Vascular Endothelial Cell Growth Factor-D>
文献数: 8
- 商品コード:622-VD-025
- メーカー:RSD
- 包装:25μg
- 価格:¥235,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:カルタヘナ該当品
説明文 |
産生:Sf 21 (baculovirus),純度:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.,由来動物:Human,M.W.:13 kDa (monomer),Genbank:2277,エンドトキシンレベル:<1.0 EU per 1 µg of the protein by the LAL method. 別名:c-fos induced growth factor (vascular endothelial growth factor D) Genbank No: 2277 Protein Accession No: O43915 |
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別包装品 | 別包装品あり | ||||||
法規制等 | カルタヘナ該当品 | ||||||
保存条件 | -20℃ | 法規備考 | |||||
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VEGF-D, Human, Recombinant, Carrier-free <Vascular Endothelial Cell Growth Factor-D>
文献数: 0
- 商品コード:622-VD-025/CF
- メーカー:RSD
- 包装:25μg
- 価格:¥235,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:カルタヘナ該当品
説明文 |
産生:Sf 21 (baculovirus),純度:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.,由来動物:Human,M.W.:13 kDa (monomer),Genbank:2277,エンドトキシンレベル:<1.0 EU per 1 µg of the protein by the LAL method. 別名:c-fos induced growth factor (vascular endothelial growth factor D) Genbank No: 2277 Protein Accession No: O43915 |
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別包装品 | 別包装品あり | ||||||
法規制等 | カルタヘナ該当品 | ||||||
保存条件 | -20℃ | 法規備考 | |||||
掲載カタログ |
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製品記事 | |||||||
関連記事 |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは?
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Phe93-Ser201, with an N-terminal Met and C-terminal 6-His tag
- Accession
- O43915
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 13 kDa (monomer)
- SDS-PAGE
- 17-20 kDa, reducing conditions
- Activity
- Measured in a cell proliferation assay using HMVEC human microvascular endothelial cells. Marconcini, L. et al. (1999) Proc. Natl. Acad. Sci. USA 96
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Additional Information
- Molecule Information
- VEGF-D
- Aliases
- FIGF
- Entrez Gene IDs
- 2277 (Human); 14205 (Mouse)
- Background
- VEGF-D
- Vascular endothelia growth factor D (VEGF-D), also known as c-fos-induced growth factor (FIGF), is a secreted glycoprotein of the VEGF/PDGF family. VEGFs regulate angiogenesis and lymphangiogenesis during development and tumor growth, and are characterized by eight conserved cysteine residues that form a cystine knot structure. VEGF-C and VEGF-D, which share 23% amino acid (aa) sequence identity, are uniquely expressed as preproproteins that contain long N- and C-terminal propeptide extensions around the VEGF homology domain (VHD). Proteolytic processing of the 354 aa VEGF-D preproprotein creates a secreted proprotein. Further processing by extracellular serine proteases, such as plasmin or furin-like proprotein convertases, forms mature VEGF-D consisting of non-covalently linked 42 kDa homodimers of the 117 aa VHD.Mature human VEGF-D shares 94%, 95%, 99%, 97% and 93% aa identity with mouse, rat, equine, canine and bovine VEGF-D, respectively. It is expressed in adult lung, heart, muscle, and small intestine, and is most abundantly expressed in fetal lungs and skin. Mouse and human VEGF-D are ligands for VEGF receptor 3 (VEGF R3, also called Flt-4) that are active across species and show enhanced affinity when processed. Processed human VEGF-D is also a ligand for VEGF R2, also called Flk-1 or KDR. VEGF R3 is strongly expressed in lymphatic endothelial cells and is essential for regulation of the growth and differentiation of lymphatic endothelium. While VEGF-C is the critical ligand for VEGF R3 during embryonic lymphatic development, VEGF-D is most active in neonatal lymphatic maturation and bone growth. Both promote tumor lymphangiogenesis. Consonant with their activity on VEGF receptors, binding of VEGF-C and VEGF-D to neuropilins contributes to VEGF R3 signaling in lymphangiogenesis, while binding to integrin α9β1 mediates endothelial cell adhesion and migration.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Co-expression of alpha9beta1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN.
Bhattacharjee RN, Chambers AF, Lala PK, Majumder M, Rodriguez-Torres M, Timoshenko AV, Torres-Garcia J, Tutunea-Fatan E, Wiebe R, Xin X
PLoS ONE 2012 7:e35094
Species: Human
Protein Application: Bioassay
Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1.
Ergun S, Irmak S, Kilic E, Kilic N, Lauke H, Loges S, Neshat-Vahid S, Obst-Pernberg K, Oliveira-Ferrer L, Singer BB, Tilki D, Weil J, Wurmbach JH
Blood 2007 110:4223-33
Species: Human
Protein Application: Bioassay
A potential role for vascular endothelial growth factor-D as an autocrine growth factor for human breast carcinoma cells.
Akahane M, Akahane T, Okajima E, Shah A, Thorgeirsson UP
Anticancer Res. 2005 25:701-7
Species: Human
Protein Application: Bioassay
Microvascular patterning is controlled by fine-tuning the Akt signal.
Benjamin LE, Dor T, Dvorak AM, Felske T, Feng D, Kornaga T, Phung T, Shiojima I, Sun JF, Upalakalin JN, Walsh K
Proc. Natl. Acad. Sci. U.S.A. 2005 102:128-33
Species: Bovine
Protein Application: Bioassay
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