E-Selectin/CD62E Fc Chimera 組換え体(リコンビナント)タンパク質 | Recombinant Mouse E-Selectin/CD62E Fc Chimera
掲載日情報：2015/01/26 現在Webページ番号：113026
R&D Systems社製の高品質なE-Selectin/CD62E Fc Chimeraの組換え体タンパク質(Recombinant Mouse E-Selectin/CD62E Fc Chimera)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月29日 10時55分現在]
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[在庫・価格 ：2025年04月29日 10時55分現在]
E-Selectin/Fc Chimera, Mouse, Recombinant
文献数： 33
- 商品コード：575-ES-100
- メーカー：RSD
- 包装：100μg
- 価格：¥90,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：NS0，純度：>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Mouse，M.W.：85.8 kDa (monomer)，Genbank：6401，エンドトキシンレベル：<1.0 EU per 1 µg of the protein by the LAL method. 別名：CD62 antigen-like family member E Genbank No： 6401 Protein Accession No： Q00690 |
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| 保存条件 | -20℃ | 法規備考 | |
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| 製品記事 | R&D Systems社 E-Selectin関連製品 |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived
- Accession
- Q00690
- Structure
- Disulfide-linked homodimer
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 85.8 kDa (monomer)
- SDS-PAGE
- 150 kDa, reducing conditions
- Activity
- Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells.When 5 x 104 cells/well are added to mouse E-Selectin/Fc Chimera coated plates (2 µg/mL with 100 µL/well), approximately 85-100% will adhere for 1 hour incubation at room temperature. Optimal dilutions should be determined by each laboratory for each application.
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Additional Information
- Molecule Information
- E-Selectin/CD62E
- Aliases
- CD62E; ELAM1; LECAM2; SELE
- Entrez Gene IDs
- 6401 (Human); 20339 (Mouse); 25544 (Rat)
- Background
- Selectins
- The Selectin family is comprised of three members, E-Selectin, L-Selectin, and P-Selectin. E-Selectin [endothelial leukocyte adhesion molecule-1 (ELAM-1), CD62E] is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha. The human and rat proteins share approximately 67% amino acid sequence identity. The mouse and rat proteins share approximately 78% amino acid sequence identity. L-Selectin (Leukocyte Selectin, LAM-1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L) is expressed constitutively on a wide variety of leukocytes. Two forms of L-Selectin have been reported, apparently arising as a result of post-translational modifications. Human and mouse L-Selectin share 76% amino acid sequence identity. Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P) is expressed by activated platelets and endothelial cells. The extracellular domains of human and mouse P-Selectin share approximately 73% amino acid sequence identity.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
Alcaide P, Bu DX, Croce KJ, Lichtman AH, Luscinskas FW, Maganto-Garcia E, Newton G, Travers R
J. Immunol. 2012 188:1421-30
Species: Mouse
Protein Application: Bioassay
Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins.
Iwata M, Kagechika H, Kato C, Ohoka Y, Song SY, Takeuchi H, Yokota A
J. Immunol. 2010 185:5289-99
Species: Mouse
Protein Application: Flow Cytometry
The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion.
Kato N, Kosugi T, Yuzawa Y
J. Am. Soc. Nephrol. 2009 20:1565-76
Species: Mouse
Protein Application: Binding Assay
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.
Ager A, Cantrell DA, Cornish GH, Feijoo C, Finlay D, Gray A, Hagenbeek TJ, Okkenhaug K, Sinclair LV, Spits H
Nat. Immunol. 2008 9:513-21
Species: Mouse
Protein Application: Flow Cytometry
Chondroitin sulfate glycosaminoglycans as major P-selectin ligands on metastatic breast cancer cell lines.
Artaud C, Hennings L, Jousheghany F, Kieber-Emmons T, Monzavi-Karbassi B, Shaaf S, Stanley JS
Int. J. Cancer 2007 120:1179-91
Species: Mouse
Protein Application: Bioassay
Varied levels of reactivity by different E-selectin/Fc constructs with cutaneous lymphocyte-associated antigen (CLA)(+) CD4(+) T cells.
Ni Z, NiZh ZImmunol. Lett. 2007 108:179-82Species: HumanProtein Application: Bioassay
Immunol. Lett. 2007 108:179-82
Species: Human
Protein Application: Bioassay
The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo.
Alcaide P, Dimitroff CJ, Fuhlbrigge RC, King SL, Lim YC, Luscinskas FW
J. Invest. Dermatol. 2007 127:1964-72
Species: Mouse
Protein Application: Bioassay
The metastatic T-cell hybridoma antigen/P-selectin glycoprotein ligand 1 is required for hematogenous metastasis of lymphomas.
Brys L, De Baetselier P, Ghassabeh GH, Mpofu N, Raes G, Vanhecke D, Verschueren H
Int. J. Cancer 2007 121:2646-52
Species: Mouse
Protein Application: Flow Cytometry
Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.
Dimitroff CJ, Fuhlbrigge RC, Kakeda M, Kupper TS, Kurokawa I, Mizutani H, Yamanaka K
J. Allergy Clin. Immunol. 2007 121:148-157.e3
Species: Human
Protein Application: Flow Cytometry
Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells.
Krause DS, Lazarides K, Van Etten RA, von Andrian UH
Nat. Med. 2006 12:1175-80
Species: Mouse
Protein Application: Flow Cytometry
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