BMP-6 組換え体(リコンビナント)タンパク質 | Recombinant Human BMP-6
掲載日情報:2015/01/26 現在Webページ番号:112956
R&D Systems社製の高品質なBMP-6の組換え体タンパク質(Recombinant Human BMP-6)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2024年05月19日 00時00分現在]
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[在庫・価格 :2024年05月19日 00時00分現在]
BMP-6, Human, Recombinant
文献数: 64
- 商品コード:507-BP-020
- メーカー:RSD
- 包装:20μg
- 価格:¥123,000
- 在庫:2個
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
産生:NS0,純度:>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Human,M.W.:15 kDa (monomer),Genbank:654,エンドトキシンレベル:<0.10 EU per 1 µg of the protein by the LAL method. 別名:BMP6 Genbank No: 654 Protein Accession No: P22004 |
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保存条件 | -20℃ | 法規備考 | |
掲載カタログ |
ニュース2019年11月15日号 p.19
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製品記事 | |||
関連記事 |
BMP-6, Human, Recombinant, Carrier-free
文献数: 0
- 商品コード:507-BP-020/CF
- メーカー:RSD
- 包装:20μg
- 価格:¥123,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 |
産生:NS0,純度:>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Human,M.W.:15 kDa (monomer),Genbank:654,エンドトキシンレベル:<0.10 EU per 1 µg of the protein by the LAL method. 別名:BMP6 Genbank No: 654 Protein Accession No: P22004 |
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法規制等 | |||
保存条件 | -20℃ | 法規備考 | |
掲載カタログ |
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製品記事 | |||
関連記事 |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
追加しました。
CF(Carrier-Free)とは?
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived, Gln382-His513
- Accession
- P22004
- Structure
- Disulfide-linked homodimer
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 15 kDa (monomer)
- SDS-PAGE
- 18 kDa, reducing conditions
- Activity
- Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250
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Additional Information
- Molecule Information
- BMP-6
- Aliases
- Vgr-1
- Entrez Gene IDs
- 654 (Human); 12161 (Mouse); 25644 (Rat)
- Background
- BMPs (Bone Morphogenetic Proteins)
- BMPs are secreted signaling molecules that comprise a subfamily of the TGF-beta superfamily and were originally identified as regulators of cartilage and bone formation. There are at least 20 structurally and functionally related BMPs, most of which play roles in embryogenesis and morphogenesis of various tissues and organs. Biologically active BMPs are usually homodimers containing a characteristic cysteine knot structure. Heterodimers, BMP-2/BMP-7 and BMP-4/BMP-7 have also been suggested to exist and function in vivo. They are more potent inducers of bone formation than their respective homodimers. In addition, heterodimers, but not homodimers, are ventral mesoderm inducers. Heterodimer activity may be mediated by a different or additional receptor subtype.Decapentaplegic (Dpp) is one of at least five TGF-beta superfamily ligands identified in the Drosophila genome. Dpp, a functional ortholog of mammalian BMP-2 and BMP-4, is a morphogen and plays an essential role in Drosophila development. Dpp regulates embryonic dorsal-ventral polarity and is required for gut morphogenesis and outgrowth and patterning of imaginal disks.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney.
Badal , Shawn S, Chang , Benny H , Danesh , Farhad R, Long , Jianyin, Rodriguez , Antony, Wang , Yin
J Biol Chem 2013 288:36202-14
Species: Human
Protein Application: cell culture
Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs).
Babitt , Jodie L, Lin , Herbert , Sun , Chia Chi, Wu , Qifang
PLoS ONE 2012 7:e46307
Species: Human
Protein Application: Surface Plasmon Resonance
Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma.
Alizadeh A, Bakkebo M, Bredahl M, Forfang L, Hilden V, Huse K, Liestol K, Myklebust J, Oksvold M, Smeland E, Walchli S
PLoS ONE 2012 7:e46117
Species: Human
Protein Application: Bioassay
Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.
Gilchrist R, Mottershead D, Ritter L
Mol Hum Reprod 2012 18:121-8
Derivation of cerebellar neurons from human pluripotent stem cells.
Bhattacharya S, Erceg S, Lukovic D, Moreno-Manzano V, Stojkovic M
Curr Protoc Stem Cell Biol 2012 20:1H.51
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.
Babitt JL, Chen S, Corradini E, Grgurevic L, Gutschow M, Hong CC, Lin HY, Lopez-Otin C, Meynard D, Stirnberg M, Sun CC, Vaja V, Vukicevic S
Blood 2011 118:747-56
Species: Human
Protein Application: Bioassay
Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
Castonguay R, Grinberg AV, Kumar R, Matthews RG, Mulivor AW, Pearsall RS, Presman E, Sako D, Seehra J, Solban N, Underwood KW, Werner ED
J. Biol. Chem. 2011 286:30034-46
Species: Human
Protein Application: Surface Plasmon Resonance
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.
Bakkebo M, Forfang L, Hilden VI, Huse K, Myklebust JH, Oksvold MP, Smeland EB, Stokke T
Eur. J. Immunol. 2011 41:3135-45
Species: Human
Protein Application: Bioassay
Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes.
Croucher PI, Grcevic D, Ivcevic S, Kovacic N, Kusec R, Lukic A, Lukic IK, Marusic A, Nemet D, Ostojic SK, Seiwerth RS
Leuk. Res. 2010 34:742-51
Species: Human
Protein Application: Bioassay
The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain.
Hubbell JA, Martino MM
FASEB J. 2010 24:4711-21
Species: Human
Protein Application: Surface Plasmon Resonance
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