CXCL12/SDF-1 alpha 組換え体(リコンビナント)タンパク質 | Recombinant Mouse CXCL12/SDF-1 alpha

掲載日情報:2015/01/26 現在Webページ番号:112830

R&D Systems社製の高品質なCXCL12/SDF-1 alphaの組換え体タンパク質(Recombinant Mouse CXCL12/SDF-1 alpha)です。
本製品は研究用です。研究用以外には使用できません。

[在庫・価格 :2025年04月27日 00時00分現在]

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SDF-1α, Mouse, Recombinant <Stromal Cell-Derived Factor-1α> <PBSF> <CXCL12α>
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 63
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説明文
産生:E. coli,純度:>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Mouse,M.W.:8 kDa,Genbank:6387,エンドトキシンレベル:<0.01 EU per 1 µg of the protein by the LAL method.
別名:CXCL12 chemokine (C-X-C motif) ligand 12
Genbank No: 6387
Protein Accession No: P40224
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保存条件 -20℃ 法規備考
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SDF-1α, Mouse, Recombinant, Carrier-free <CXCL12>
10日程度 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 0
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説明文
産生:E. coli,純度:>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Mouse,M.W.:8 kDa,Genbank:6387,エンドトキシンレベル:<0.01 EU per 1 µg of the protein by the LAL method.
別名:CXCL12 chemokine (C-X-C motif) ligand 12
Genbank No: 6387
Protein Accession No: P40224
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事
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[在庫・価格 :2025年04月27日 00時00分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

SDF-1α, Mouse, Recombinant <Stromal Cell-Derived Factor-1α> <PBSF> <CXCL12α>

文献数: 63

説明文 産生:E. coli,純度:>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Mouse,M.W.:8 kDa,Genbank:6387,エンドトキシンレベル:<0.01 EU per 1 µg of the protein by the LAL method.
別名:CXCL12 chemokine (C-X-C motif) ligand 12
Genbank No: 6387
Protein Accession No: P40224
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事
関連記事

SDF-1α, Mouse, Recombinant, Carrier-free <CXCL12>

文献数: 0

説明文 産生:E. coli,純度:>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.,由来動物:Mouse,M.W.:8 kDa,Genbank:6387,エンドトキシンレベル:<0.01 EU per 1 µg of the protein by the LAL method.
別名:CXCL12 chemokine (C-X-C motif) ligand 12
Genbank No: 6387
Protein Accession No: P40224
別包装品 別包装品あり
法規制等
保存条件 -20℃ 法規備考
掲載カタログ

製品記事
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バルク注文に関して

バルク包装品も承ります。お気軽にお問合せ下さい。

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CF(Carrier-Free)とは?

R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。

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Product Details

Source
E. coli-derived, Lys22-Lys89
Accession
Q4FJL5
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Predicted Molecular Mass
8 kDa
Activity
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR4.The ED50 for this effect is typically 0.15-0.6 ng/mL.Measured by its ability to chemoattract 5-10 day cultured human peripheral blood lymphocytes (PBL).The ED50 for this effect is typically 3-9 ng/mL.

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Additional Information

Molecule Information
CXCL12/SDF-1 alpha
Aliases
undefined
Entrez Gene IDs
6387 (Human); 20315 (Mouse); 493806 (Feline)
Background
CXCL12/SDF-1 (PBSF)
CXCL12/Stromal Cell-derived Factor 1 (SDF-1) is a member of the CXC chemokine ligand superfamily. Six alternatively spliced CXCL12/SDF-1 isoforms have been identified including, CXCL12/SDF-1 alpha, CXCL12/SDF-1 beta, and CXCL12/SDF-1 gamma. CXCL12/SDF-1 alpha is 89 amino acids (aa) in length with a predicted molecular weight of 10 kDa, CXCL12/SDF-1 beta is 93 aa in length with a predicted molecular weight of 10.6 kDa, and CXCL12/SDF-1 gamma is 119 aa in length with a predicted molecular weight of 13.7 kDa. The mouse CXCL12/SDF-1 orthologs share 99% aa sequence identity with the human protein. The alpha and beta isoforms are ubiquitously expressed while the gamma isoform is primarily expressed in the heart. CXCL12/SDF-1 isoforms are chemotactic for T lymphocytes and monocytes. It is cardio protective and has also been shown to hinder CXCR4-mediated HIV infection of T cells.

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Citations

Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.

Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach.
Chawla A, Donnelly J, Houghton J, Zavros Y
PLoS ONE 2013 8:e75225
Species: Mouse
Protein Application: Bioassay


Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization.
Alberts A, Bhargava A, Chen J, Chen X, Dong B, Gao W, Jin F, Jorgensen L, Siminovitch K, Su H, Zhang J, Zhang S
PLoS ONE 2013 8:e80500
Species: Mouse
Protein Application: Bioassay


Influence of hypoxia-inducible factor 1-alpha on dendritic cell differentiation and migration.
Forster I, Johnson RS, Kohler T, Reizis B, Weighardt H
Eur. J. Immunol. 2012 42:1226-36
Species: Mouse
Protein Application: Bioassay


The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury.
Ge G, Li Y, Liu H, Liu S, Luo X, Wang X, Xue W
PLoS ONE 2012 7:e34608
Species: Mouse
Protein Application: Bioassay


Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control.
Cha HR, Kim ED, Ko HJ
J. Immunol. 2011 187:3044-52
Species: Mouse
Protein Application: Bioassay


The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.
Ippagunta SK, Malireddi RK, Shaw PJ
Nat. Immunol. 2011 12:1010-6
Species: Mouse
Protein Application: Bioassay


CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1.
Haberl GC, Kollmar O, Menger MD, Nickels RM, Rupertus K, Scheuer C, Schilling MK, Tilton B
Int. J. Cancer 2010 126:1302-15
Species: Mouse
Protein Application: Bioassay


CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice.
Di J, Jin H, Lin QD, Lin Y, Xu L, Zhong Y
Fertil. Steril. 2009 91:2687-96
Species: Mouse
Protein Application: Bioassay


CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.
Anunu R, Karin N, Meiron M, Wildbaum G, Zohar Y
J. Exp. Med. 2008 205:2643-55
Species: Mouse
Protein Application: Bioassay


Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Brown KK, Cool CD, Cosgrove GP, Jones CC, Lenox CC, Petty JM, Poynter ME, Rai PR, Sueblinvong V, Suratt BT, Weiss DJ
J. Immunol. 2007 178:8148-57
Species: Mouse
Protein Application: Bioassay


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