CCL3/MIP-1 alpha 組換え体(リコンビナント)タンパク質 | Recombinant Mouse CCL3/MIP-1 alpha
掲載日情報：2015/01/26 現在Webページ番号：112801
R&D Systems社製の高品質なCCL3/MIP-1 alphaの組換え体タンパク質(Recombinant Mouse CCL3/MIP-1 alpha)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年07月01日 16時15分現在]
| 詳細 | 商品名 |
|
文献数 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
MIP-1α, Mouse, Recombinant <Macrophage Inflammatory Protein-1α> |
|
40 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
MIP-1α, Mouse, Recombinant, Carrier-free <Macrophage Inflammatory Protein-1α> |
|
本製品は製品内容等が変更されました
変更先製品 |
0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
[在庫・価格 ：2025年07月01日 16時15分現在]
MIP-1α, Mouse, Recombinant <Macrophage Inflammatory Protein-1α>
文献数： 40
- 商品コード：450-MA-010
- メーカー：RSD
- 包装：10μg
- 価格：¥62,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain，由来動物：Mouse，M.W.：7.8 kDa，Genbank：6348，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：C-C motif chemokine 3 Genbank No： 6348 Protein Accession No： Q5QNW0 |
||||||
|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
|
||||||
| 製品記事 | |||||||
| 関連記事 | |||||||
追加しました。
バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
追加しました。
CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
追加しました。
Product Details
- Source
- E. coli-derived, Ala24-Ala92
- Accession
- Q5QNW0
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 7.8 kDa
- Activity
- Measured by its ability to chemoattract 2-day cultured human monocytes.The ED50 for this effect is typically 5 - 25 ng/mL.Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR5.The ED50 for this effect is typically 0.4 - 2.0 ng/mL.
追加しました。
Additional Information
- Molecule Information
- CCL3/MIP-1 alpha
- Aliases
- LD78a; MIP-1 alpha
- Entrez Gene IDs
- 6348 (Human); 20302 (Mouse); 25542 (Rat); 448787 (Canine)
- Background
- CCL3/MIP-1 alpha
- MIP-1 alpha (macrophage inflammatory protein 1 alpha) is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T cells, B cells and eosinophils.The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.
追加しました。
Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms.
Berberich N, Krombach F, Luckow B, Puhr-Westerheide D, Reichel CA, Uhl B, Wymann MP, Zahler S, Zuchtriegel G
Blood 2012 120:880-90
Species: Mouse
Protein Application: In Vivo
TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice.
Akira S, Chung DH, Go H, Kim HS
J. Immunol. 2011 187:4007-17
Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines.
Beal D, Bouchard JC, Cruikshank WW, Kim J, Natarajan S, Remick DG, Vaickus LJ
Am. J. Pathol. 2011 179:2730-9
Species: N/A
Protein Application: ELISA Standard
Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis.
Binder NB, Erben RG, Hoffmann O, Mack M, Niederreiter B, Pap T, Redlich K, Smolen JS, Stange R, Stulnig TM
Nat. Med. 2009 15:417-24
Species: Mouse
Protein Application: Bioassay
Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus specificity and a critical role in collagen IV remodeling.
Bihari P, Khandoga A, Krombach F, Linder S, Moser CM, Rehberg M, Reichel CA
J. Leukoc. Biol. 2008 83:864-74
Species: Mouse
Protein Application: In Vivo
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process.
Baba T, Li YY, Matsushima K, Mukaida N, Wu Y
J. Immunol. 2008 181:6384-93
Species: Mouse
Protein Application: Bioassay
Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases.
Baiu DC, Fabry Z, Karman J, Reinke E, Sandor M, Zozulya AL
J. Immunol. 2007 178:520-9
Species: Mouse
Protein Application: Bioassay
Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
Bais C, Blanchard D, Carano RA, Ferrara N, Ho C, Liang XH, Meng YG, Peale FV, Ross J, Shojaei F, Tan M, van Bruggen N, Wu X, Yao J, Yu L, Zhong C
Nature 2007 450:825-31
Species: Mouse
Protein Application: Bioassay
Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway.
Benjamim CF, Candea AL, Costa KA, Costa MF, Henriques MG, Penido C, Souza MC
Int. Immunol. 2007 20:129-39
Species: Mouse
Protein Application: In Vivo
Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.
Cao X, Chen G, Chen T, Li N, Liu Q, Ma P, Wang J
Biochem. Biophys. Res. Commun. 2006 345:1122-30
Species: Mouse
Protein Application: Bioassay
追加しました。
製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。