FGF-8b 組換え体(リコンビナント)タンパク質 | Recombinant Human/Mouse FGF-8b
掲載日情報：2015/01/26 現在Webページ番号：112722
R&D Systems社製の高品質なFGF-8bの組換え体タンパク質(Recombinant Human/Mouse FGF-8b)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2026年04月06日 00時00分現在]
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[在庫・価格 ：2026年04月06日 00時00分現在]
FGF-8b, Human/Mouse, Recombinant <Fibroblast Growth Factor-8b>
文献数： 52
- 商品コード：423-F8-025
- メーカー：RSD
- 包装：25μg
- 価格：¥54,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human, Mouse，M.W.：22.5 kDa，Genbank：2253，エンドトキシンレベル：<0.01 EU per 1 µg of the protein by the LAL method. 別名：AIGF Genbank No： 2253 Protein Accession No： NP_006110(human) NP_001159834(mouse) |
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| 保存条件 | -20℃ | 法規備考 | |
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FGF-8b, Human/Mouse, Recombinant, Carrier-free
文献数： 0
- 商品コード：423-F8-025/CF
- メーカー：RSD
- 包装：25μg
- 価格：¥54,000
- 在庫：2個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human, Mouse，M.W.：22.5 kDa，Genbank：2253，エンドトキシンレベル：<0.01 EU per 1 µg of the protein by the LAL method. 別名：AIGF Genbank No： 2253 Protein Accession No： NP_006110(human) NP_001159834(mouse) |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Gln23-Arg215, with an N-terminal Met
- Accession
- NP_006110 (human), NP_001159834 (mouse)
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 22.5 kDa
- SDS-PAGE
- 23 kDa, reducing conditions
- Activity
- Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109
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Additional Information
- Molecule Information
- FGF-8
- Aliases
- AIGF; HBGF-8
- Entrez Gene IDs
- 2253 (Human); 14179 (Mouse); 29349 (Rat)
- Background
- FGF-8
- FGF-8 is a member of the fibroblast growth factor family that was originally discovered as a growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Alternate splicing of mouse FGF-8 mRNA generates eight secreted isoforms, designated a - h, but only FGF-8a, b, e and f exist in humans. FGF-8 contains a 22 amino acid (aa) signal sequence, an N-terminal domain that varies according to the isoform (30 aa for FGF-8b; 20 aa for the shortest, FGF-8a), a 125 aa FGF domain and a 37 aa proline-rich C-terminal sequence. The FGF domain of FGF-8 shares the most aa identity with FGF-17 (75%) and FGF-18 (67%), and the three form an FGF subfamily. Mouse FGF-8b shares 100% aa identity with human FGF-8b. FGF-8 is widely expressed during embryogenesis, and mediates epithelial-mesenchymal transitions. It plays an organizing and inducing role during gastrulation, and regulates patterning of the midbrain/hindbrain, eye, ear, limbs and heart in the embryo. The isoforms may play different roles in development. FGF-8b shows the strongest receptor affinity and oncogenic transforming capacity although FGF-8a and FGF-8e are also transforming and have been found in human prostate, breast or ovarian tumors. FGF-8 shows limited expression in the normal adult, but low levels are found in the reproductive and genitourinary tract, peripheral leukocytes and bone marrow hematopoietic cells.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish.
McCarroll , Matthew , Nechiporuk , Alex V
PLoS ONE 2013 8:e85087
Species: Zebrafish
Protein Application: In Vivo
Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture.
Hu , Yaohua, Li , Peng, Luo , Chuanmin, Ni , Na, Ren , Huixia, Su , Huanxing, Wan , Jian-Bo
PLoS ONE 2013 8:e84504
Species: Mouse
Protein Application: Bioassay
Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
Knowles MA, Tomlinson DC
Am. J. Pathol. 2010 177:2379-86
Species: Human
Protein Application: Bioassay
Differentiation of ES cells into cerebellar neurons.
Hatten ME, Salero E
Proc. Natl. Acad. Sci. U.S.A. 2007 104:2997-3002
Species: Mouse
Protein Application: Bioassay
FGFs, Wnts and BMPs mediate induction of VEGFR-2 (Quek-1) expression during avian somite development.
Christ B, Geetha-Loganathan P, Huang R, Nimmagadda S, Scaal M
Dev. Biol. 2007 305:421-9
Species: Quail
Protein Application: In Vivo
Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm.
Gill JG, Kyba M, Lindsley RC, Murphy KM, Murphy TL
Development 2006 133:3787-96
Species: Mouse
Protein Application: Bioassay
Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue.
Bae YK, Hibi M, Shimizu T
Development 2006 133:4709-19
Species: Zebrafish
Protein Application: Bioassay
Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.
Amano T, Hiji M, Hirabayashi T, Kohriyama T, Matsumoto M, Nagano Y, Nakamura T, Sakai N, Takahashi T, Yagi T, Yamashita H
J. Neurochem. 2006 98:45-56
Species: Mouse
Protein Application: Bioassay
Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx.
Burch J, Creazzo TL, Hutson MR, Kirby ML, Li YX, Sato AK, Stadt HA, Zhang P
Dev. Biol. 2006 295:486-97
Species: Chicken
Protein Application: Bioassay
Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements.
Bangs F, Blaschke R, Farrell ER, Rappold G, Tickle C, Tiecke E
Dev. Biol. 2006 298:585-96
Species: Chicken
Protein Application: In Vivo
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