IL-17A 組換え体(リコンビナント)タンパク質 | Recombinant Mouse IL-17A
掲載日情報:2015/01/26 現在Webページ番号:112720
R&D Systems社製の高品質なIL-17Aの組換え体タンパク質(Recombinant Mouse IL-17A)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2025年07月22日 14時35分現在]
詳細 | 商品名 |
|
文献数 | ||
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IL-17, Mouse, Recombinant |
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86 | |||
IL-17, Mouse, Recombinant, Carrier-free |
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0 | |||
[在庫・価格 :2025年07月22日 14時35分現在]
IL-17, Mouse, Recombinant
文献数: 86
- 商品コード:421-ML-025
- メーカー:RSD
- 包装:25μg
- 価格:¥46,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
IL-17, Mouse, Recombinant, Carrier-free
文献数: 0
- 商品コード:421-ML-025/CF
- メーカー:RSD
- 包装:25μg
- 価格:¥46,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは?
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Thr22-Ala158
- Accession
- Q62386.1
- Structure
- Disulfide-linked homodimer
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 15.5 kDa (monomer)
- Activity
- Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3
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Additional Information
- Molecule Information
- IL-17/IL-17A
- Aliases
- CTLA-8; IL17A
- Entrez Gene IDs
- 3605 (Human); 16171 (Mouse); 301289 (Rat); 481837 (Canine)
- Background
- IL-17 Ligands
- The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Macrophages participate in IL-17-mediated inflammation.
Baldeviano GC, Barin JG, Caturegli P, Chen P, Cihakova D, Ong S, Quader F, Rose NR, Talor MV, Wu L, Zheng D
Eur. J. Immunol. 2012 42:726-36
Species: Mouse
Protein Application: Bioassay
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A 2012 109:9971-6
IL-17A and TNF-alpha Exert Synergistic Effects on Expression of CXCL5 by Alveolar Type II Cells In Vivo and In Vitro.
Dai N, Favara M, Gonzales L, Guttentag S, Liu Y, Malcolm KC, Mei J, Wang P, Worthen GS, Yang G, Zhang P
J. Immunol. 2011 186:3197-205
Species:
Protein Application: In Vivo
IL-17 and VEGF are necessary for efficient corneal nerve regeneration.
Burns AR, Han L, Li Z, Rumbaut RE, Smith CW
Am. J. Pathol. 2011 178:1106-16
Species: Mouse
Protein Application: In Vivo
Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice.
Amemiya H, Fujii H, Hara M, Hosomura N, Kono H, Ogiku M, Tsuchiya M
J. Immunol. 2011 187:4818-25
Species: Mouse
Protein Application: In Vivo
IL-17RA signaling amplifies antibody-induced arthritis.
Alekseeva E, Kim ND, Luster AD, Sadik CD
PLoS ONE 2011 6:e26342
Species: Mouse
Protein Application: Bioassay
IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease.
Burch LH, Cook DN, Nakano H, Nakano K, Whitehead GS, Wilson RH
J. Allergy Clin. Immunol. 2011 129:207-15.e1-5
Species: Mouse
Protein Application: In Vivo
Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection.
Barke RA, Chang Y, Charboneau R, Ma J, Roy S, Wan J, Wang J
Infect. Immun. 2010 78:830-7
Species: Mouse
Protein Application: In Vivo
Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
Fontana A, Moransard M, Sawitzky M, Suter T
Glia 2010 58:559-71
Species: Mouse
Protein Application: Bioassay
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.
Blauvelt A, Cheng G, Cheung AL, Cho JS, Farzam DM, Garcia NC, Kolls JK, Magorien JE, Miller LS, Modlin RL, Monroe HR, Pietras EM, Ramos RI
J. Clin. Invest. 2010 120:1762-73
Species: Bacteria
Protein Application: Bioassay
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