NRG1-beta 1/HRG1-beta 1 EGF Domain 組換え体(リコンビナント)タンパク質 | Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain
掲載日情報:2015/01/26 現在Webページ番号:112641
R&D Systems社製の高品質なNRG1-beta 1/HRG1-beta 1 EGF Domainの組換え体タンパク質(Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2025年04月26日 08時35分現在]
詳細 | 商品名 |
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文献数 | ||
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Heregulin-β1, EGF Domain, Human, Recombinant <HRG-β1> |
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53 | |||
Heregulin1-β1 EGF Domain, Human, Recombinant, Carrier-free <Neuregulin1-β1> <NRG1-β1> <HRG1-β1> |
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0 | |||
[在庫・価格 :2025年04月26日 08時35分現在]
Heregulin-β1, EGF Domain, Human, Recombinant <HRG-β1>
文献数: 53
- 商品コード:396-HB-050
- メーカー:RSD
- 包装:50μg
- 価格:¥86,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
Heregulin1-β1 EGF Domain, Human, Recombinant, Carrier-free <Neuregulin1-β1> <NRG1-β1> <HRG1-β1>
文献数: 0
- 商品コード:396-HB-050/CF
- メーカー:RSD
- 包装:50μg
- 価格:¥86,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは?
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Thr176-Lys246
- Accession
- NP_039250
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 8 kDa
- SDS-PAGE
- 8 kDa, reducing conditions
- Activity
- Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48
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Additional Information
- Molecule Information
- Neuregulin-1 beta 1/NRG1 beta 1
- Aliases
- undefined
- Entrez Gene IDs
- 3084 (Human); 211323 (Mouse); 112400 (Rat)
- Background
- Neuregulins
- The neuregulin (also known as heregulin) cytokine family is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. The NRG1 gene is the most pleiotropic, encoding more than 14 soluble or transmembrane proteins. NRG1 isoforms can be classified into type I (neu differentiation factor, NDF; heregulin, HRG; acetylcholine receptor inducing activity, ARIA), type II (glial growth factor, GGF) and type III (sensory and motor neuron-derived factor, SMDF) isoforms. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance.
Beguelin W, Charreau E, Cordo Russo R, Diaz Flaque M, Elizalde P, Galigniana N, Guzman P, O'Brien N, Proietti C, Roa J, Schillaci R, Tkach M, Venturutti L
Oncogene 2014 0:
Species: Human
Protein Application: Bioassay
Cellular Effects of HER3-Specific Affibody Molecules.
Frejd FY, Gedda L, Gostring L, Hoiden-Guthenberg I, Lofblom J, Malm M, Stahl S
PLoS ONE 2012 7:e40023
Species: Human
Protein Application: Bioassay
Subchronic peripheral neuregulin-1 increases ventral hippocampal neurogenesis and induces antidepressant-like effects.
Davoli MA, Dominguez-Lopez S, Mahar I, Mechawar N, Qiang C, Rachalski A, Tan S, Turecki G
PLoS ONE 2011 6:e26610
Species: Mouse
Protein Application: In Vivo
Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors.
Buonanno A, Gonzalez CM, Hernandez L, Kwon OB, Neddens J, Paredes D, Vullhorst D
Proc. Natl. Acad. Sci. U.S.A. 2008 105:15587-92
Species: Rat
Protein Application: In Vivo
Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts.
Bai X, Beryt M, Brdlik C, Higaki JN, Jin P, Jorgensen B, Kumari R, Lau FW, Lindley P, Liu J, Ni I, Rozzelle J, Sarup J, Shepard HM, Turin L, Watson SA, Zhang J
Mol. Cancer Ther. 2008 7:3223-36
Species: Human
Protein Application: Bioassay
Identification of neuregulin as a factor required for formation of aligned spermatogonia.
Chapman KM, Garbers DL, Hamra FK, Nguyen D
J. Biol. Chem. 2007 282:721-30
Species: Rat
Protein Application: Bioassay
Prolactin and heregulin override DNA damage-induced growth arrest and promote phosphatidylinositol-3 kinase-dependent proliferation in breast cancer cells.
Chakravarti P, Henry MK, Quelle FW
Int. J. Oncol. 2005 26:509-14
Species: Human
Protein Application: Bioassay
Central administration of transforming growth factor-alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters.
Davis FC, Gilbert JL, Snodgrass-Belt P
Brain Res. 2005 1038:171-82
Species: Hamster
Protein Application: In Vivo
Heregulin ameliorates the dystrophic phenotype in mdx mice.
Bogdanovich S, Edvinsson L, Fischer MD, Flake AW, Hansen-Schwartz J, Javazon EH, Jensen CJ, Khurana TS, Krag TO
Proc. Natl. Acad. Sci. U.S.A. 2004 101:13856-60
Species: Mouse
Protein Application: In Vivo
Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke.
Ford BD, Ford G, Jiang J, Xu Z
Biochem. Biophys. Res. Commun. 2004 322:440-6
Species: Rat
Protein Application: In Vivo
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