TIM-1/KIM-1/HAVCR 組換え体(リコンビナント)タンパク質 | Recombinant Rat TIM-1/KIM-1/HAVCR
掲載日情報：2015/01/26 現在Webページ番号：112569
R&D Systems社製の高品質なTIM-1/KIM-1/HAVCRの組換え体タンパク質(Recombinant Rat TIM-1/KIM-1/HAVCR)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月26日 17時55分現在]
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[在庫・価格 ：2025年04月26日 17時55分現在]
TIM-1, Rat, Recombinant <KIM-1> <HAVCR>
文献数： 0
- 商品コード：3689-TM-050
- メーカー：RSD
- 包装：50μg
- 価格：¥90,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：NS0，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Rat，M.W.：25.4 kDa，Genbank：26762，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：CD365 Genbank No： 26762 Protein Accession No： O54947 |
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| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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| 製品記事 | TIM DuoSet Kit |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived, Ser18-Val238, with a C-terminal 6-His tag
- Accession
- O54947
- Structure
- Monomer
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 25.4 kDa
- SDS-PAGE
- 55-65 kDa, reducing conditions
- Activity
- Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.Human T lymphocytes cultured for 72 hours with PHA were incubated for an additional 3 days in 96 well plates coated with 500 ng/mL anti‑CD3 and rrKIM-1.The ED50 for this effect is typically 0.4‑2 µg/mL.Optimal dilutions should be determined by each laboratory for each application.
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Additional Information
- Molecule Information
- TIM-1/KIM-1/HAVCR
- Aliases
- HAVCR1; KIM-1
- Entrez Gene IDs
- 26762 (Human); 171283 (Mouse); 286934 (Rat)
- Background
- TIM-1/KIM-1/HAVCR
- TIM-1 (T cell-immunoglobulin-mucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. This gene family is involved in the regulation of Th1 and Th2 cell mediated immunity. Human TIM-1 is synthesized as a 359 amino acid (aa) precursor that contains a 20 aa signal sequence, a 270 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 48 aa cytoplasmic domain. The ECD contains one V-type Ig like domain and a mucin region characterized by multiple PTTTTL motifs. The mucin region undergoes extensive O-linked glycosylation.The TIM-1 gene is highly polymorphic and undergoes alternate splicing. For instance, the presence of a six aa sequence (MTTTVP) at position #137 of the mature molecule is associated with protection from atopy in people with a history of hepatitis A. There are two cytoplasmic alternate splice forms of TIM-1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. Both are identical through the first 323 aa of their precursors. TIM-1b contains a tyrosine phosphorylation motif that is not present in TIM-1a. TIM-1 is also known to circulate as a soluble form. Constitutive cleavage by an undefined MMP (possibly ADAM33) releases an 85-90 kDa soluble molecule. The ECD of human TIM-1 is 50% and 43% aa identical to mouse and canine TIM-1 ECD, respectively. The only two reported ligands for TIM-1 are TIM-4 and the hepatitis A virus. However, others are believed to exist, and based on the ligand for TIM-3, one may well be an S-type lectin. TIM1 ligation induces T cell proliferation and promotes cytokine production.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
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