Cyclophilin A 組換え体(リコンビナント)タンパク質 | Recombinant Human Cyclophilin A
掲載日情報：2015/01/26 現在Webページ番号：112539
R&D Systems社製の高品質なCyclophilin Aの組換え体タンパク質(Recombinant Human Cyclophilin A)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2026年06月03日 00時00分現在]
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Cyclophilin A(aa1-165), Human, Recombinant, Carrier-free |
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[在庫・価格 ：2026年06月03日 00時00分現在]
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Met1-Glu165
- Accession
- P62937
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 18 kDa
- SDS-PAGE
- 17 kDa, reducing conditions
- Activity
- Measured by its ability to inhibit calcineurin phosphatase activity in the presence of Cyclosporin A.The IC50 for inhibition of calcineurin activity is <300 nM, as measured under the described conditions.
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Additional Information
- Molecule Information
- Cyclophilin A
- Aliases
- CYPA; CYPH; PPIA; Rotamase
- Entrez Gene IDs
- 5478 (Human); 268373 (Mouse); 25518 (Rat)
- Background
- Cyclophilin A
- Cyclophilin A, also known as Peptidylprolyl Isomerase A, PPIA, CYPA, and CYPH, was originally characterized for its ability to catalyze the transition between cis and trans proline residues critical for proper folding of proteins. Ubiquitously expressed, Cyclophilin A has a predicted molecular weight of 17 kDa and is proinflammatory cytokine that is secreted in response to inflammatory stimuli. Human Cyclophilin A shares 95% amino acid identity with both the mouse and rat orthologs. Cyclophilin A is the main target of the immunosuppressive drug Cyclosporin A. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit Calcineurin Phosphatase activity and prevent incorporation of Cyclophilin A into viral particles. Cyclophilin A is known to be incorporated into many viruses, including HIV1 and Hepatitis C, where it may be involved in functions such as viral assembly, replication, and infectivity. In addition, Cyclophilin A has been shown to promote atherosclerosis via binding to Extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN) on CD34+ progenitor cells and stimulating differentiation to foam cells, an essential step during atherosclerotic plaque formation in blood vessels. Cyclophilin A-induced disruption of blood-brain barrier function is thought to contribute to the increased risk of developing Alzheimer’s disease in individuals that possess one or two Apolipoprotein E4 alleles.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation.
Bigalke B, Borst O, Daub K, Gawaz M, Heidenreich O, Herouy Y, Kramer BF, Lang MR, Langer HF, Lindemann S, May AE, Schmidt R, Schonberger T, Schott M, Seizer P
Atherosclerosis 2010 209:51-7
Species: Human
Protein Application: Bioassay
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