BMP-9 組換え体(リコンビナント)タンパク質 | Recombinant Human BMP-9
掲載日情報：2015/01/26 現在Webページ番号：112422
R&D Systems社製の高品質なBMP-9の組換え体タンパク質(Recombinant Human BMP-9)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年05月13日 13時15分現在]
| 詳細 | 商品名 |
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文献数 | ||
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BMP-9, Human, Recombinant |
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本製品は取扱中止になりました | 27 | ||
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BMP-9, Human, Recombinant, Carrier-free |
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[在庫・価格 ：2025年05月13日 13時15分現在]
BMP-9, Human, Recombinant, Carrier-free
文献数： 0
- 商品コード：3209-BP-010/CF
- メーカー：RSD
- 包装：10μg
- 価格：¥106,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Chinese Hamster Ovary cell line, CHO-derived, Ser320-Arg429
- Accession
- Q9UK05
- Structure
- Disulfide-linked homodimer
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 12.1 kDa (monomer)
- SDS-PAGE
- 13 kDa, reducing conditions
- Activity
- Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250
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Additional Information
- Molecule Information
- BMP-9
- Aliases
- GDF2; GDF-2
- Entrez Gene IDs
- 2658 (Human); 12165 (Mouse)
- Background
- BMPs (Bone Morphogenetic Proteins)
- BMPs are secreted signaling molecules that comprise a subfamily of the TGF-beta superfamily and were originally identified as regulators of cartilage and bone formation. There are at least 20 structurally and functionally related BMPs, most of which play roles in embryogenesis and morphogenesis of various tissues and organs. Biologically active BMPs are usually homodimers containing a characteristic cysteine knot structure. Heterodimers, BMP-2/BMP-7 and BMP-4/BMP-7 have also been suggested to exist and function in vivo. They are more potent inducers of bone formation than their respective homodimers. In addition, heterodimers, but not homodimers, are ventral mesoderm inducers. Heterodimer activity may be mediated by a different or additional receptor subtype.Decapentaplegic (Dpp) is one of at least five TGF-beta superfamily ligands identified in the Drosophila genome. Dpp, a functional ortholog of mammalian BMP-2 and BMP-4, is a morphogen and plays an essential role in Drosophila development. Dpp regulates embryonic dorsal-ventral polarity and is required for gut morphogenesis and outgrowth and patterning of imaginal disks.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Burton L, Chan E, Fridlyand J, Koeppen H, Li J, Lin E, Merchant M, Moffat J, Neve R, Peng J, Penuel E, Ribas A, Settleman J, Sosman J, Sutherlin DP, Wang Y, Wilson TR, Yan Y
Nature 2012 487:505-9
Species: Human
Protein Application: Bioassay
Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs).
Babitt , Jodie L, Lin , Herbert , Sun , Chia Chi, Wu , Qifang
PLoS ONE 2012 7:e46307
Species: Human
Protein Application: Surface Plasmon Resonance
BMP9 and BMP10 are critical for postnatal retinal vascular remodeling.
Blood 2012 119:6162-71
Species: Human
Protein Application: Bioassay
BMP9 regulates endoglin-dependent chemokine responses in endothelial cells.
Brogan , Louise, Conley , Barbara, Liaw , Lucy, Lindner , Volkhard, O'Neill , Christin, Pinz , Ilka, Romero , Diana, Tweedie , Eric, Vary , Calvin P, Young , Kira
Blood 2012 120:4263-73
Species: Human
Protein Application: Bioassay
Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
Castonguay R, Grinberg AV, Kumar R, Matthews RG, Mulivor AW, Pearsall RS, Presman E, Sako D, Seehra J, Solban N, Underwood KW, Werner ED
J. Biol. Chem. 2011 286:30034-46
Species: Human
Protein Application: Bioassay
Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations.
Bidart M, Mallet C, Ricard N
Blood 2010 116:1604-12
Species: Human
Protein Application: Bioassay
A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum.
, Herrera B, Inman GJ
BMC Cell Biol. 2009 10:20
Species: Mouse
Protein Application: Bioassay
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.
Bailly S, David L, Feige JJ, Mallet C, Mazerbourg S
Blood 2007 109:1953-61
Species: Human
Protein Application: Bioassay
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.
Gabayan V, Ganz T, Goodnough JB, Lin L, Nemeth E, Valore EV
Blood 2007 110:2182-9
Species: Mouse
Protein Application: Bioassay
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