TGF-alpha 組換え体(リコンビナント)タンパク質 | Recombinant Human TGF-alpha
掲載日情報：2015/01/26 現在Webページ番号：112091
R&D Systems社製の高品質なTGF-alphaの組換え体タンパク質(Recombinant Human TGF-alpha)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年10月16日 20時15分現在]
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TGF-α, Human, Recombinant, Carrier-free <Transforming Growth Factor-α> |
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[在庫・価格 ：2025年10月16日 20時15分現在]
TGF-α, Human, Recombinant, Carrier-free <Transforming Growth Factor-α>
文献数： 48
- 商品コード：239-A-100
- メーカー：RSD
- 包装：100μg
- 価格：¥65,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain，由来動物：Human，M.W.：6 kDa，Genbank：7039，エンドトキシンレベル：<0.01 EU per 1 µg of the protein by the LAL method. 別名：protransforming growth factor alpha Genbank No： 7039 Protein Accession No： P01135 |
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| 保存条件 | -20℃ | 法規備考 | |||||
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| 関連記事 | R&D Systems製品 価格改定（値下げ）のご案内 |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Val40-Ala89
- Accession
- P01135
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 6 kDa
- Activity
- Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Marquardt, H. et al. (1984) Science 223
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Additional Information
- Molecule Information
- TGF-alpha
- Aliases
- TGFA
- Entrez Gene IDs
- 7039 (Human)
- Background
- TGF-alpha
- Transforming Growth Factor-&alpha (TGF-alpha was originally isolated from the conditioned media of oncogenically-transformed cells as an EGF-like bioactivity. TGF-alpha is a member of the EGF family of cytokines that are synthesized as transmembrane precursors and are characterized by the presence of one or several EGF structural units in their extracellular domain. The soluble forms of these cytokines are released from the transmembrane protein by proteolytic cleavage. Membrane-bound proTGF-alpha is biologically active and seems to play a role in mediation of cell-cell adhesion and in juxtacrine stimulation of adjacent cells. Expression of TGF-alpha is widespread in tumors and transformed cells. TGF-alpha is also expressed in normal tissues during embryogenesis and in adult tissues, including pituitary, brain, keratinocytes and macrophages. Mature TGF-alpha shows approximately 93% amino acid sequence identity with mouse or rat TGF-alpha and is not species-specific in its biological effects.TGF-α binds to the EGF receptor and activates the receptor tyrosine kinase. Accordingly, TGF-alpha shows a similar potency to EGF as a mitogen for fibroblasts and as an inducer of epithelial development in vivo. TGF-alpha is reportedly more potent than EGF as an angiogenic factor in vivo and as a stimulator for keratinocyte migration. The EGF receptor gene represents the cellular homologue of the avian v-erb-B oncogene.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A 2012 109:9971-6
CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells.
Kim S, Lewis C, Nadel JA
J. Immunol. 2011 186:3392-400
Species: Human
Protein Application: Bioassay
Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells.
Kim S, Lewis C, Nadel JA
Exp. Cell Res. 2011 317:2650-60
Species: Human
Protein Application: Bioassay
Evidence for altered Wnt signaling in psoriatic skin.
Gudjonsson JE, Johnston A, Stoll SW
J. Invest. Dermatol. 2010 130:1849-59
Species: Human
Protein Application: Bioassay
The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress.
Drazen JM, Park JA, Tschumperlin DJ
J. Biol. Chem. 2010 285:29817-25
Species: Human
Protein Application: Bioassay
Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine.
Crombet T, de la Torre A, Garcia B, Gonzalez G, Lage A, Leonard I, Martinez R, Mazorra Z, Neninger E, Viada C
Clin. Cancer Res. 2008 14:840-6
Species: Human
Protein Application: ELISA development
Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.
Cheng H, Fidler IJ, Hale KS, Langley RR, Nakamura T, Rebhun RB, Sasaki T, Tsan RZ
Am. J. Pathol. 2008 173:205-16
Species: Human
Protein Application: Bioassay
Ependymal stem cells divide asymmetrically and transfer progeny into the subventricular zone when activated by injury.
Bryant PJ, Fallon JH, Gleason D, Guerra M, Liu JC
Neuroscience 2008 156:81-8
Species: Rat
Protein Application: In Vivo
Development and validation of sandwich ELISA microarrays with minimal assay interference.
Crowley SA, Gonzalez RM, Seurynck-Servoss SL
J. Proteome Res. 2008 7:2406-14
Species: N/A
Protein Application: ELISA Standard
Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells.
Armant DR, Chiang PJ, Romero R, Smith SM, Wolff GS
Biol. Reprod. 2007 77:53-60
Species: Human
Protein Application: Bioassay
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