EGF 組換え体(リコンビナント)タンパク質 | Recombinant Human EGF
掲載日情報：2015/01/26 現在Webページ番号：112084
R&D Systems社製の高品質なEGFの組換え体タンパク質(Recombinant Human EGF)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月26日 08時35分現在]
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EGF, Human, Recombinant, Carrier-free <Epidermal Growth Factor> |
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[在庫・価格 ：2025年04月26日 08時35分現在]
EGF, Human, Recombinant, Carrier-free <Epidermal Growth Factor>
文献数： 294
- 商品コード：236-EG-200
- メーカー：RSD
- 包装：200μg
- 価格：¥32,000
- 在庫：3個以上
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：6 kDa，Genbank：1950，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：beta-urogastrone Genbank No： 1950 Protein Accession No： P01133 |
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| 保存条件 | -20℃ | 法規備考 | |||||
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Asn971-Arg1023, with an N-terminal Met
- Accession
- P01133
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 6 kDa
- SDS-PAGE
- 6 kDa, reducing conditions
- Activity
- Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al. (1991) Proc. Natl. Acad. Sci. USA 88
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Additional Information
- Molecule Information
- EGF
- Aliases
- HOMG4; URG; Urogastrone
- Entrez Gene IDs
- 1950 (Human); 13645 (Mouse); 25313 (Rat)
- Background
- EGF
- Epidermal Growth Factor (EGF) was originally discovered in crude preparations of nerve growth factor prepared from mouse submaxillary glands. Its actions were shown to induce early eyelid opening, incisor eruption, hair growth inhibition, and stunt growth when injected into newborn mice. Human EGF was isolated from urine based on its inhibitory effect on gastric secretion and named urogastrone, accordingly. EGF is prototypic of a family of growth factors that are derived from membrane-anchored precursors. All members of this family are characterized by the presence of at least one EGF structural unit (defined by the presence of a conserved 6 cysteine motif that forms three disulfide bonds) in their extracellular domain. EGF is initially synthesized as a 130 kDa precursor transmembrane protein containing 9 EGF units. The mature soluble EGF sequence corresponds to the EGF unit located proximal to the transmembrane domain. The membrane EGF precursor is capable of binding to the EGF receptor and was reported to be biologically active.A wide variety of in vitro and in vivo biological effects have been ascribed to EGF and other members of the EGF family. The best documented activity of EGF is its ability to promote proliferation and differentiation of mesenchymal and epithelial cells. In vitro, EGF is a mitogen for fibroblasts, epithelial and endothelial cells, and promotes colony formation of epidermal cells in culture. In vivo, EGF induces epithelial development, promotes angiogenesis, and inhibits gastric acid secretion.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Diacylglycerol kinase delta modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2).
Crotty T, Nakano T, Stafforini D, Topham M
J Biol Chem 2013 288:1439-47
Species: Human
Protein Application: Bioassay
The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer.
Giese N, Giese T, Gladkich J, Hage C, Herr I, Labsch S, Mattern J, Nwaeburu C, Rausch V, Schonsiegel F
Cell Death Dis 2013 4:e627
Species: Human
Protein Application: Bioassay
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A.
DeVecchio , Jennifer, Gantt , Gerald A, Hitomi , Masahiro, Hjelmeland , Anita B, Jarrar , Awad M, Kalady , Matthew , Lathia , Justin, Leahy , Patrick, Lotti , Fiorenza, Mace , Adam, Pai , Rish K, Rich , Jeremy N, Sukhdeo , Kumar, Vasanji , Amit
J Exp Med 2013 210:2851-72
Species: Human
Protein Application: Cell Culture Substrate
Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-kappaB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.
Bera A, Cao L, Chiao P, Freeman J, Zhao S
PLoS ONE 2013 8:e82282
Species: Human
Protein Application: Bioassay
Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes.
D'Souza SL, Emdad L, Germano IM, Kothari HP, Qadeer ZA
Stem Cells Dev. 2012 21:404-10
Species: Human
Protein Application: Bioassay
Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.
Chin EN, Fakhraldeen SA, Goel S
J. Biol. Chem. 2012 287:16454-66
Species: Mouse
Protein Application: Bioassay
Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c.
Banfi A, Di Maggio N, Heberer M, Martin I, Mehrkens A, Papadimitropoulos A, Schaeren S
Stem Cells 2012 30:1455-64
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Burton L, Chan E, Fridlyand J, Koeppen H, Li J, Lin E, Merchant M, Moffat J, Neve R, Peng J, Penuel E, Ribas A, Settleman J, Sosman J, Sutherlin DP, Wang Y, Wilson TR, Yan Y
Nature 2012 487:505-9
Species: Human
Protein Application: Bioassay
The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
Fischer A, Scott M, Volkov L, Zelinka C
PLoS ONE 2012 7:e44477
Species: Chicken
Protein Application: In Vivo
Regulation of IL-33 expression by IFN-gamma and tumor necrosis factor-alpha in normal human epidermal keratinocytes.
J. Invest. Dermatol. 2012 132:2593-600
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