FGF acidic 組換え体(リコンビナント)タンパク質 | Recombinant Human FGF acidic
掲載日情報:2015/01/26 現在Webページ番号:112057
R&D Systems社製の高品質なFGF acidicの組換え体タンパク質(Recombinant Human FGF acidic)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 :2025年07月16日 15時15分現在]
詳細 | 商品名 |
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文献数 | ||
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FGF-Acidic, Human, Recombinant <Fibroblast Growth Factor-Acidic> |
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27 | |||
FGF-Acidic, Human, Recombinant, Carrier-free <Fibroblast Growth Factor-Acidic> |
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0 | |||
[在庫・価格 :2025年07月16日 15時15分現在]
FGF-Acidic, Human, Recombinant <Fibroblast Growth Factor-Acidic>
文献数: 27
- 商品コード:232-FA-025
- メーカー:RSD
- 包装:25μg
- 価格:¥36,000
- 在庫:2個
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
FGF-Acidic, Human, Recombinant, Carrier-free <Fibroblast Growth Factor-Acidic>
文献数: 0
- 商品コード:232-FA-025/CF
- メーカー:RSD
- 包装:25μg
- 価格:¥36,000
- 在庫:無(未発注)
- 納期:10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは?
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Phe16-Asp155, with an N-terminal Met
- Accession
- NP_000791
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 15.5 kDa
- Activity
- Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Rizzino, A. et al. (1988) Cancer Res. 48
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Additional Information
- Molecule Information
- FGF acidic
- Aliases
- alpha-ECGF; beta-ECGF; FGF1; FGF-1; HBGF-1
- Entrez Gene IDs
- 2246 (Human); 14164 (Mouse); 25317 (Rat); 281160 (Bovine)
- Background
- FGF acidic
- FGF acidic, also known as FGF-1, ECGF, and HBGF-1, is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal, ectodermal, and endodermal origin. FGF acidic is secreted following associations with S100A13, copper ions, and synaptotagmin 1. Its association with heparan sulfate is a prerequisite for activation of FGF receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta, exported to the cytosol, dephosphorylated, and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors.
Bachmann A, Hutley LJ, Kim YH, Liu DF, Luo X, Newell FS, Prins JB, Schmitz-Peiffer C, Turner N, Webster JA, Whitehead JP, Widberg CH, Yang GS
Diabetes 2012 61:124-36
Species: Human
Protein Application: Bioassay
Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease.
Darby S, Gnanapragasam VJ, Leung HY, Mathers ME, Murphy T, Robson CN, Thomas H
Br. J. Cancer 2009 101:1891-9
Species: Human
Protein Application: Bioassay
Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation.
Cowherd SN, Hoffman MP, Lassiter KS, Likar KM, Patel VN, Ron D, Sher I, Turnbull JE, Yates EA, Zisman-Rozen S
J. Biol. Chem. 2008 283:9308-17
Species: Mouse
Protein Application: Bioassay
The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice.
Bagby GJ, Nelson S, Shellito JE, Siggins R, Welsh DA, Zhang P
Stem Cells 2008 26:1778-86
Species: Mouse
Protein Application: Bioassay
Liver-specific activities of FGF19 require Klotho beta.
Blackmore C, Desnoyers LR, Lin BC, Wang M
J. Biol. Chem. 2007 282:27277-84
Species: Human
Protein Application: Bioassay
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
Eftekhari S, Elkin M, Hoffman MP, Hossain R, Knox SM, Lathrop CA, Likar KM, Patel VN, Vlodavsky I, Whitelock JM
Development 2007 134:4177-86
Species: Mouse
Protein Application: Bioassay
Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro.
Baharvand H, Farrokhi A, Hashemi SM, Kazemi Ashtiani S
Int. J. Dev. Biol. 2006 50:645-52
Species: Human
Protein Application: Bioassay
MIP-1alpha (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma.
Bergsagel PL, Claudio JO, Heise C, Li Z, Masih-Khan E, Nadeem V, Paterson J, Roodman D, Stewart AK, Trudel S, Wei E
Blood 2006 108:3465-71
Species: Human
Protein Application: Bioassay
Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis.
Bikfalvi A, Canron X, Detmar M, Henderson JE, Hong YK, Kunstfeld R, Larrieu-Lahargue F, Min M, Nguyen L, Shin JW
Mol. Biol. Cell 2005 17:576-84
Species: Human
Protein Application: Bioassay
Liver tissue engineering at extrahepatic sites in mice as a potential new therapy for genetic liver diseases.
Dake MD, Kay MA, Kuge H, Naka H, Nakajima Y, Ohashi K, Waugh JM, Yamanouchi M, Yokoyama T, Yoshioka A
Hepatology 2005 41:132-40
Species: Mouse
Protein Application: In Vivo
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