B7-H4 組換え体(リコンビナント)タンパク質 | Recombinant Mouse B7-H4
掲載日情報：2015/01/26 現在Webページ番号：111975
R&D Systems社製の高品質なB7-H4の組換え体タンパク質(Recombinant Mouse B7-H4)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年07月16日 13時55分現在]
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[在庫・価格 ：2025年07月16日 13時55分現在]
Recombinant Mouse B7-H4, CF (50 UG)
文献数： 2
- 商品コード：2154-B7-050
- メーカー：RSD
- 包装：50μg
- 価格：¥71,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：NS0，純度：>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Mouse，M.W.：26.6 kDa，Genbank：79679，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：B7h.5 Genbank No： 79679 Protein Accession No： Q7TSP5 |
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| 保存条件 | -20℃ | 法規備考 | |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived, Phe29-Pro258, with a C-terminal 10-His tag
- Accession
- Q7TSP5
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 26.6 kDa
- SDS-PAGE
- 45-55 kDa, reducing conditions
- Activity
- Measured by its ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T lymphocytes.The presence of Recombinant Mouse B7-H4 at 10 µg/mL inhibited the anti-CD3 response by >30%. Optimal dilutions should be determined by each laboratory for each application.
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Additional Information
- Molecule Information
- B7-H4
- Aliases
- B7S1; B7x; Vtcn1
- Entrez Gene IDs
- 79679 (Human); 242122 (Mouse)
- Background
- B7-H4
- B7-H4, also known as B7x and B7S1, is a member of the B7 family of immune costimulatory proteins. Mature B7-H4 is a 50 kDa - 80 kDa glycosylated molecule with a 28 kDa protein core. Partial sensitivity to cleavage by PI-PLC suggests a possible GPI linkage of mouse B7-H4 to the cell membrane. The 230 aa extracellular region of B7-H4 contains one Ig-like V-set domain and one Ig-like C2-set domain which is followed by a hydrophobic C-terminal region. Within the ECD, mouse B7-H4 shares 90% and 99% aa sequence identity with human and rat B7-H4, respectively. It shares 21% - 29% aa sequence identity with B7-1, B7-2, B7-H1, B7-H2, B7-H3, and PD-L2.B7-H4 expression is induced on mitogen- or LPS-activated B cells, T cells, dendritic cells, monocytes, and macrophages and blocked by GM-CSF or IL-4. It is also expressed on various normal epithelia and upregulated in several carcinomas and renal tubule epithelial cell lesions. B7-H4 is expressed on the surface of macrophages but intracellularly in ovarian and breast cancer cells. It is found in the serum and ascites fluid of cancer patients. B7-H4 binds an unidentified ligand on activated T cells which is distinct from BTLA, CD28, CTLA4, ICOS, and PD-1. Exposure to B7-H4 inhibits antigen-dependent induction of T cell proliferation and activation. Alternatively, B7-H4 expressing renal tubular epithelial cells promote T cell activation. Regulatory T cells, IL-6, and IL-10 induce B7-H4 expression on antigen presenting cells which fosters tumor growth by dampening the anti-tumor immune response. B7-H4 also promotes the malignant transformation of epithelial cells by protecting them from apoptosis. Despite evidence for the involvement of B7-H4 in immune regulation, mice deficient in its expression do not show significant immune deficiencies, suggesting compensation by other molecules in vivo.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
B7-H3 participates in the development of experimental pneumococcal meningitis by augmentation of the inflammatory response via a TLR2-dependent mechanism.
Blankson S, Chen X, Feng X, Ni H, Quinn EM, Redmond HP, Wang J, Wang JH
J. Immunol. 2012 189:347-55
Species: Mouse
Protein Application: In Vivo
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