GDNF 組換え体(リコンビナント)タンパク質 | Recombinant Human GDNF
掲載日情報：2015/01/26 現在Webページ番号：111959
R&D Systems社製の高品質なGDNFの組換え体タンパク質(Recombinant Human GDNF)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2024年06月22日 20時55分現在]
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GDNF, Human, Recombinant <Grial Derived Neurotrophic Factor> |
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GDNF, Human, Recombinant, Carrier-free |
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[在庫・価格 ：2024年06月22日 20時55分現在]
GDNF, Human, Recombinant <Grial Derived Neurotrophic Factor>
文献数： 62
- 商品コード：212-GD-010
- メーカー：RSD
- 包装：10μg
- 価格：¥76,000
- 在庫：1個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
産生：NS0，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：11.6 kDa (monomer)，Genbank：2668，エンドトキシンレベル：<1.0 EU per 1 µg of the protein by the LAL method. 別名：Astrocyte-derived trophic factor Genbank No： 2668 Protein Accession No： P39905 |
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| 保存条件 | -20℃ | 法規備考 | |||||
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GDNF, Human, Recombinant, Carrier-free
文献数： 0
- 商品コード：212-GD-010/CF
- メーカー：RSD
- 包装：10μg
- 価格：¥76,000
- 在庫：2個
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
産生：NS0，純度：>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.，由来動物：Human，M.W.：11.6 kDa (monomer)，Genbank：2668，エンドトキシンレベル：<1.0 EU per 1 µg of the protein by the LAL method. 別名：Astrocyte-derived trophic factor Genbank No： 2668 Protein Accession No： P39905 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
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| 製品記事 | |||||||
| 関連記事 | |||||||
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived, Arg109-Ile211
- Accession
- P39905
- Structure
- Disulfide-linked homodimer
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 11.6 kDa (monomer)
- Activity
- Measured by its binding ability in a functional ELISA.Immobilized Recombinant Human GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera (Catalog # 714-GR) at 1 µg/mL can bind Recombinant Human GDNF with an apparent KD <1 nM.Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells.The ED50 for this effect is typically 4-16 ng/mL in the presence of Recombinant Human GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera (Catalog # 714‑GR).
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Additional Information
- Molecule Information
- GDNF
- Aliases
- undefined
- Entrez Gene IDs
- 2668 (Human); 25453 (Rat)
- Background
- GDNF
- Glial Cell Line-derived Neurotrophic Factor (GDNF) is a neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-β superfamily. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
RET PLC-gamma phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration.
Fritz N, Lundgren TK, Nakahata K, Rebellato P, Uhlen P, Zhang S
PLoS ONE 2012 7:e31258
Species: Human
Protein Application: Bioassay
Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties.
Avarbock MR, Brinster RL, Goodyear SM, Kubota H, Wu X
FASEB J. 2011 25:2604-14
Species: Rabbit
Protein Application: Bioassay
Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
Castonguay R, Grinberg AV, Kumar R, Matthews RG, Mulivor AW, Pearsall RS, Presman E, Sako D, Seehra J, Solban N, Underwood KW, Werner ED
J. Biol. Chem. 2011 286:30034-46
Species: Human
Protein Application: Surface Plasmon Resonance
Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain.
Bankiewicz KS, Forsayeth J, Hadaczek P, Johnston L
Neuropharmacology 2010 58:1114-21
Species: Rat
Protein Application: In Vivo
Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons.
Aigner L, Brustle O, Couillard-Despres S, Endl E, Koch P, Ladewig J, Meiners B, Opitz T
Stem Cells 2008 26:1705-12
Species: Human
Protein Application: Bioassay
A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi.
Lu B, PereiraPerrin M
Infect. Immun. 2008 76:3530-8
Species: Bacteria
Protein Application: ELISA capture
Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury.
Huang HY, Lin HI, Lo LW, Tzeng SF, Wang YC, Wu YT, Yang CS
Biomaterials 2008 29:4546-53
Species: Rat
Protein Application: In Vivo
Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage.
Chen X, Lavaute TM, Li XJ, Lyons EA, Pankratz MT, Zhang SC
Stem Cells 2007 25:1511-20
Species: Human
Protein Application: Bioassay
SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.
Ai X, Do AT, Emerson CP, Kitazawa T, Kusche-Gullberg M, Labosky PA
Development 2007 134:3327-38
Species: Mouse
Protein Application: Bioassay
Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system.
Goldstein AM, Nagy N
Dev. Biol. 2006 293:203-17
Species: Chicken
Protein Application: Bioassay
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