CXCL8/IL-8 組換え体(リコンビナント)タンパク質 | Recombinant Human CXCL8/IL-8
掲載日情報：2015/01/26 現在Webページ番号：111942
R&D Systems社製の高品質なCXCL8/IL-8の組換え体タンパク質(Recombinant Human CXCL8/IL-8)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2024年05月17日 00時01分現在]
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IL-8, Human, Recombinant, Carrier-free <CXCL8> |
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[在庫・価格 ：2024年05月17日 00時01分現在]
IL-8, Human, Recombinant <CXCL8>
文献数： 131
- 商品コード：208-IL-050
- メーカー：RSD
- 包装：50μg
- 価格：¥104,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
産生：E. coli，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：8 kDa，Genbank：3576，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：3-10C Genbank No： 3576 Protein Accession No： P10145.1 |
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| 別包装品 | 別包装品あり | ||||||
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| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
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| 製品記事 |
IL-8 ELISA Kit／抗体／換え体タンパク質 |
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IL-8, Human, Recombinant, Carrier-free <CXCL8>
文献数： 1
- 商品コード：208-IL-050/CF
- メーカー：RSD
- 包装：50μg
- 価格：¥104,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
産生：E. coli，純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：8 kDa，Genbank：3576，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：3-10C Genbank No： 3576 Protein Accession No： P10145.1 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 掲載カタログ |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Ser28-Ser99
- Accession
- P10145.1
- Purity
- >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 8 kDa
- Activity
- Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR2.The ED50 for this effect is typically 0.5-2.5 ng/mL.Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils. Schröder, J.M. et al. (1987) J. Immunol. 139
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Additional Information
- Molecule Information
- CXCL8/IL-8
- Aliases
- GCP1; IL8; LAI; MDNCF; NAP1; NCF; TCF; TSG1
- Entrez Gene IDs
- 3576 (Human); 396880 (Porcine); 403850 (Canine); 493836 (Feline)
- Background
- CXCL8/IL-8
- CXCL8 was originally discovered and purified as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocytederived neutrophil chemotactic factor (MDNCF), T lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. CXCL8 is a member of the alpha (CXC) subfamily of chemokines, which also includes platelet factor-4, GRO, and IP10.CXCL8 is a potent chemoattractant for neutrophils. In addition, CXCL8 also has a wide range of other proinflammatory effects. CXCL8 causes degranulation of neutrophil specific granules and azurophilic granules. CXCL8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, CXCL8 is also chemotactic for basophils, T cells and eosinophils. CXCL8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. CXCL8 was also reported to be angiogenic both in vivo and in vitro.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
Caillat-Zucman S, Choukem SP, Dupuy S, Lambert M, Lebbe C, Pages C, Tognarelli S, Zucman D
PLoS Pathog. 2012 8:e1002486
Species: Human
Protein Application: Bioassay
Daily exposure to dust alters innate immunity.
Larsson K, Palmberg L, Sahlander K
PLoS ONE 2012 7:e31646
Species:
Protein Application: ELISA Standard
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Burton L, Chan E, Fridlyand J, Koeppen H, Li J, Lin E, Merchant M, Moffat J, Neve R, Peng J, Penuel E, Ribas A, Settleman J, Sosman J, Sutherlin DP, Wang Y, Wilson TR, Yan Y
Nature 2012 487:505-9
Species: Human
Protein Application: Bioassay
Mycobacterium tuberculosis infection and tissue factor expression in macrophages.
Kothari H, Pendurthi U, Rao L, Vankayalapati R
PLoS ONE 2012 7:e45700
Species: Human
Protein Application: Bioassay
Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.
Barcelos LS, Cassali GD, Doni A, Garcia CC, Guabiraba R, Locati M, Mirolo M, Pinho V, Rachid MA, Roffe E, Russo RC, Sousa LP, Souza AL, Teixeira MM
J. Leukoc. Biol. 2011 89:269-82
Species: Human
Protein Application: Bioassay
Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture.
Burton VJ, Butler LM, Jeffery HC, McGettrick HM, Nash GB, Rainger GE, Savage CO, Stone PC
Exp. Cell Res. 2011 317:276-92
Species: Human
Protein Application: Bioassay
Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells.
Broxmeyer HE, Hangoc G, Kinzfogl J
Blood 2011 118:565-75
Species: Human
Protein Application: Bioassay
CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B.
Burger M, Catusse J, Follo M, Hartmann TN, Leick M, Nibbs RJ, Veelken H
Immunology 2010 129:536-46
Species: Human
Protein Application: Bioassay
IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
Bergin DA, Byrne B, Greally P, McElvaney NG, O'Kennedy R, O'Neill SJ, Reeves EP, Smith SG, Williamson M
J. Immunol. 2010 184:1642-52
Species: Human
Protein Application: Binding Assay
RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo.
Bierhaus A, Buschmann K, Frommhold D, Hepper I, Kamphues A, Kupatt C, Lange-Sperandio B, Lukic IK, Moser M, Nawroth PP, Poeschl J, Pruenster M, Ryschich E, Schymeinsky J, Socher I, Sperandio M, Walzog B, Zablotskaya V
Blood 2010 116:841-9
Species: Human
Protein Application: Bioassay
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