EGF 組換え体(リコンビナント)タンパク質 | Recombinant Mouse EGF
掲載日情報：2015/01/26 現在Webページ番号：111915
R&D Systems社製の高品質なEGFの組換え体タンパク質(Recombinant Mouse EGF)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月26日 09時55分現在]
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[在庫・価格 ：2025年04月26日 09時55分現在]
EGF, Mouse, Recombinant, Carrier-free
文献数： 68
- 商品コード：2028-EG-200
- メーカー：RSD
- 包装：200μg
- 価格：¥59,000
- 在庫：3個以上
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 産生：E. coli，純度：>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Mouse，M.W.：6.2 kDa，Genbank：1950，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：beta-urogastrone Genbank No： 1950 Protein Accession No： NP_034243 |
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| 保存条件 | -20℃ | 法規備考 | |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derived, Asn977-Arg1029, with an N-terminal Met
- Accession
- NP_034243
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 6.2 kDa
- Activity
- Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al. (1991) Proc. Natl. Acad. Sci. USA 88
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Additional Information
- Molecule Information
- EGF
- Aliases
- HOMG4; URG; Urogastrone
- Entrez Gene IDs
- 1950 (Human); 13645 (Mouse); 25313 (Rat)
- Background
- EGF
- Epidermal Growth Factor (EGF) was originally discovered in crude preparations of nerve growth factor prepared from mouse submaxillary glands. Its actions were shown to induce early eyelid opening, incisor eruption, hair growth inhibition, and stunt growth when injected into newborn mice. Human EGF was isolated from urine based on its inhibitory effect on gastric secretion and named urogastrone, accordingly. EGF is prototypic of a family of growth factors that are derived from membrane-anchored precursors. All members of this family are characterized by the presence of at least one EGF structural unit (defined by the presence of a conserved 6 cysteine motif that forms three disulfide bonds) in their extracellular domain. EGF is initially synthesized as a 130 kDa precursor transmembrane protein containing 9 EGF units. The mature soluble EGF sequence corresponds to the EGF unit located proximal to the transmembrane domain. The membrane EGF precursor is capable of binding to the EGF receptor and was reported to be biologically active.A wide variety of in vitro and in vivo biological effects have been ascribed to EGF and other members of the EGF family. The best documented activity of EGF is its ability to promote proliferation and differentiation of mesenchymal and epithelial cells. In vitro, EGF is a mitogen for fibroblasts, epithelial and endothelial cells, and promotes colony formation of epidermal cells in culture. In vivo, EGF induces epithelial development, promotes angiogenesis, and inhibits gastric acid secretion.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection.
Geng , Jian-Guo, Geng , Zhen H, Spence , Jason R, Zhou , Wei-Jie
Nature 2013 501:107-11
Species: Mouse
Protein Application: cell culture
Isolation and characterization of neural stem/progenitor cells from post-stroke cerebral cortex in mice.
Fujimori Y, Gotoh A, Kubo S, Matsuyama T, Nakagomi N, Nakagomi T, Nakano-Doi A, Nishizaki T, Saino O, Soma T, Stern DM, Taguchi A, Yoshikawa H
Eur. J. Neurosci. 2009 29:1842-52
Species: Mouse
Protein Application: Bioassay
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice.
Barrick CJ, O'Brien KD, Rajamannan NM, Roberts RB, Rojas M, Smyth SS, Suitt CB, Threadgill DW
Am. J. Physiol. Heart Circ. Physiol. 2009 297:H65-75
Species: Mouse
Protein Application: In Vivo
Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivation.
Dagvadorj J, Khuda II, Koide N, Komatsu T, Naiki Y, Noman AS, Tumurkhuu G, Yokochi T, Yoshida T
Biochem. Biophys. Res. Commun. 2008 374:683-7
Species: Mouse
Protein Application: Bioassay
Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation.
Arumugam TV, Cheng A, Ffrench-Constant C, Griffioen K, Laryea G, Lathia JD, Magnus T, Mattson MP, Mughal MR, Okun E, Selvaraj PK, Tang SC
J. Neurosci. 2008 28:13978-84
Species: Mouse
Protein Application: Bioassay
Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells.
Brustle O, Gossrau G, Konang R, Schmandt T, Thiele J
Stem Cells 2007 25:939-49
Species: Mouse
Protein Application: Bioassay
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.
Alitalo K, Downward J, Gupta S, Haiko P, Nicke B, Nye E, Ramjaun AR, Stamp G, Wang Y, Warne PH
Cell 2007 129:957-68
Species: Mouse
Protein Application: Bioassay
Bcl-XL/Bax proteins direct the fate of embryonic cortical precursor cells.
Chang MY, Jo AY, Kang CS, Kang JS, Kim JS, Kim SY, Lee SH, Lee YS, Nakashima K, Ochiai W, Park CH, Shim JW, Sun W
Mol. Cell. Biol. 2007 27:4293-305
Species: Mouse
Protein Application: Bioassay
Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx.
Burch J, Creazzo TL, Hutson MR, Kirby ML, Li YX, Sato AK, Stadt HA, Zhang P
Dev. Biol. 2006 295:486-97
Species: Chicken
Protein Application: Bioassay
EphB4 provides survival advantage to squamous cell carcinoma of the head and neck.
Broek D, Crowe DL, Gill PS, Krasnoperov V, Kumar SR, Masood R, Reddy RK, Schonthal AH, Singh J, Sinha UK, Xia G, Zozulya S
Int. J. Cancer 2006 119:1236-48
Species: Human
Protein Application: Bioassay
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