B7-1/CD80 Fc Chimera 組換え体(リコンビナント)タンパク質 | Recombinant Human B7-1/CD80 Fc Chimera
掲載日情報：2015/01/26 現在Webページ番号：111660
R&D Systems社製の高品質なB7-1/CD80 Fc Chimeraの組換え体タンパク質(Recombinant Human B7-1/CD80 Fc Chimera)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年04月26日 15時15分現在]
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[在庫・価格 ：2025年04月26日 15時15分現在]
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived
- Accession
- NP_005182
- Structure
- Disulfide-linked homodimer
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 51.3 kDa (monomer)
- SDS-PAGE
- 70-90 kDa, reducing conditions
- Activity
- Measured by its ability to induce IL-2 secretion by Jurkat human acute T cell leukemia cells. Freeman, G.J. et al. (1993) Science 262
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Additional Information
- Molecule Information
- B7-1/CD80
- Aliases
- CD80
- Entrez Gene IDs
- 941 (Human); 12519 (Mouse); 25408 (Rat)
- Background
- B7-1
- B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 canbind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells,activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily.Human B7-1 is a 288 amino acid (aa) protein containing a 34 aa signal peptide, a 208 aa extracellular domain, a 21 aa transmembrane domain, and a 25 aa cytoplasmic domain. Human B7-1 and B7-2 share 26% amino acid identity. Human and mouse B7-1 share 44% amino acid identity. However, it has been observed that both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA 4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA4 critical binding sites.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Establishment of long-term tolerance to SRBC in dogs by recombinant canine CTLA4-Ig.
Graves SS, Loretz C, McCune JS, Mielcarek M, Peterson L, Stone D, Storb R
Transplantation 2009 88:317-22
Species: Canine
Protein Application: ELISA capture
Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.
Narazaki M, Segarra M, Tosato G
Blood 2008 111:4126-36
Species: Human
Protein Application: Control
Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.
Fieger CB, Kerr SC, Rosen SD, Snapp KR
J. Immunol. 2008 181:1480-90
Species: Human
Protein Application: Bioassay
The soluble forms of CD28, CD86 and CTLA-4 constitute possible immunological markers in patients with abdominal aortic aneurysm.
Kakoulidou M, Sakthivel P, Shively V
J. Intern. Med. 2007 261:399-407
Species: N/A
Protein Application: ELISA Standard
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A.
Narazaki M, Tosato G
Blood 2006 107:3892-901
Species: N/A
Protein Application: ELISA Standard
ICOS cooperates with CD28, IL-2, and IFN-gamma and modulates activation of human naive CD4+ T cells.
Bensi T, Bernardone IS, Castelli L, Chiocchetti A, Comi C, Dianzani U, Dong C, Ferretti M, Mesturini R, Nicola S, Rojo JM, Yagi J
Eur. J. Immunol. 2006 36:2601-12
Species: Human
Protein Application: Bioassay
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