Semaphorin 3A Fc Chimera 組換え体(リコンビナント)タンパク質 | Recombinant Human Semaphorin 3A Fc Chimera
掲載日情報：2015/01/26 現在Webページ番号：111577
R&D Systems社製の高品質なSemaphorin 3A Fc Chimeraの組換え体タンパク質(Recombinant Human Semaphorin 3A Fc Chimera)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2024年04月30日 00時00分現在]
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Semaphorin 3A/Fc Chimera, Human, Recombinant, Carrier-free |
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[在庫・価格 ：2024年04月30日 00時00分現在]
Semaphorin 3A/Fc Chimera, Human, Recombinant, Carrier-free
文献数： 28
- 商品コード：1250-S3-025
- メーカー：RSD
- 包装：25μg
- 価格：¥94,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
産生：NS0，純度：>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：113.5 kDa (monomer)，Genbank：10371，エンドトキシンレベル：<0.10 EU per 1 µg of the protein by the LAL method. 別名：(semaphorin) 3A Genbank No： 10371 Protein Accession No： Q14563 |
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| 保存条件 | -20℃ | 法規備考 | |
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| 製品記事 |
R＆D Systems社のSemaphorin 3A関連製品 |
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived
- Accession
- Q14563
- Structure
- Disulfide-linked homodimer
- Purity
- >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 113.5 kDa (monomer)
- SDS-PAGE
- 120 kDa, 90 kDa and 37 kDa, reducing conditions
- Activity
- Measured by its ability to cause collapse of chick embryonic dorsal root ganglia (DRG) neuron growth cones.20-60 ng/mL of Recombinant Human Semaphorin 3A Fc Chimera causes >50% growth cone collapse in the presence of 10 ng/mL of Recombinant Humanbeta ‑NGF (Catalog # 256-GF).Measured by its binding ability in a functional ELISA.Immobilized Recombinant Human Semaphorin 3A Fc Chimera at 2 µg/mL (100 µL/well) can bind Recombinant Rat Neuropilin‑1 Fc Chimera (Catalog # 566-N1) with a linear range of 0.8-100 ng/mL.Optimal dilutions should be determined by each laboratory for each application.
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Additional Information
- Molecule Information
- Semaphorin 3A
- Aliases
- Sema3A
- Entrez Gene IDs
- 10371 (Human)
- Background
- Semaphorins
- The Semaphorins make up the largest family of axon guidance cues yet described. Semaphorins are divided into 8 classes (classes 3-7 found in vertebrates). Class 3 Semaphorins are secreted, classes 4 through 6 are transmembrane proteins, and class 7 are membrane associated via glycosylphosphatidylinositol (GPI) linkage. They are characterized structurally by a conserved ~400 amino acid sema domain. They are classically described as collapsing factors and mediators of axon repulsion, although they may also act as context-dependent chemoattractants. Semaphorins have been shown to have roles in cardiovasculardevelopment and in the regulation of immune cell antigen presentation. Receptors or receptor complexes that mediate semaphorin signaling include proteins of the Neuropilin and Plexin families.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model.
Chakraborty G, Kumar S, Mishra R
PLoS ONE 2012 7:e33633
Species: Human
Protein Application: Bioassay
Measles virus modulates dendritic cell/T-cell communication at the level of plexinA1/neuropilin-1 recruitment and activity.
Avota E, Bortlein C, Mueller N, Schneider-Schaulies S, Tran-Van H
Eur. J. Immunol. 2011 41:151-63
Species: Human
Protein Application: Bioassay
Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse.
Kabayama H, Takeuchi M, Taniguchi M
J. Neurosci. 2011 31:7357-64
Species: Chicken
Protein Application: Bioassay
Specific association of increased vascular endothelial growth factor expression and its receptors with macrophage differentiation of HL-60 leukemia cells.
Ezaki J, Hirota-Komatsu S, Ohsaka A, Shibata M, Shinohara F, Yoshida T
Biochem. Biophys. Res. Commun. 2008 368:543-9
Species: Human
Protein Application: Bioassay
Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor.
Acevedo LM, Barillas S, Cheresh DA, Gothert JR, Weis SM
Blood 2008 111:2674-80
Species: Human
Protein Application: Bioassay
Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.
Narazaki M, Segarra M, Tosato G
Blood 2008 111:4126-36
Species: Human
Protein Application: Bioassay
VEGF promotes vascular sympathetic innervation.
Damon DH, Marko SB
Am. J. Physiol. Heart Circ. Physiol. 2008 294:H2646-52
Species: Rat
Protein Application: Bioassay
Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice.
Arsic N, Carrer A, Giacca M, Moimas S, Pattarini L, Sinagra G, Sinigaglia M, Tafuro S, Zacchigna S, Zentilin L
J. Clin. Invest. 2008 118:2062-75
Species: Human
Protein Application: Bioassay
Mitochondrial membrane potential in axons increases with local nerve growth factor or semaphorin signaling.
Hollenbeck PJ, Verburg J
J. Neurosci. 2008 28:8306-15
Species: Chicken
Protein Application: Bioassay
The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1.
Arap W, Jaalouk DE, Lahdenranta J, Ozawa MG, Pasqualini R, Schlingemann RO, Sun J
Cancer Res. 2007 67:9623-9
Species: N/A
Protein Application: Bioassay
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