Kallikrein 5 組換え体(リコンビナント)タンパク質 | Recombinant Human Kallikrein 5
掲載日情報：2015/01/26 現在Webページ番号：111481
R&D Systems社製の高品質なKallikrein 5の組換え体タンパク質(Recombinant Human Kallikrein 5)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年07月10日 17時35分現在]
| 詳細 | 商品名 |
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文献数 | ||
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Kallikrein 5, Human, Recombinant, Carrier-free |
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14 | |||
[在庫・価格 ：2025年07月10日 17時35分現在]
Kallikrein 5, Human, Recombinant, Carrier-free
文献数： 14
- 商品コード：1108-SE-010
- メーカー：RSD
- 包装：10μg
- 価格：¥86,000
- 在庫：無(発注済)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
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バルク注文に関して
※バルク包装品も承ります。お気軽にお問合せ下さい。
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- Mouse myeloma cell line, NS0-derived, Ile67-Ser293, with a C-terminal 10-His tag
- Accession
- Q9Y337
- Structure
- Mature form
- Purity
- >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
- Predicted Molecular Mass
- 31 kDa
- SDS-PAGE
- 40 kDa, reducing conditions
- Activity
- Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC (Catalog # ES011).The specific activity is >200 pmol/min/µg, as measured under the described conditions.
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Additional Information
- Molecule Information
- Kallikrein 5
- Aliases
- KLK5; KLK-L2; SCTE
- Entrez Gene IDs
- 25818 (Human); 68668 (Mouse); 690603 (Rat)
- Background
- Kallikreins
- The human tissue kallikrein (KLK) gene family contains 15 members that play important roles in cancer. Notably, kallikrein-1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. Kallikrein-3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. Kallikrein-4 is specifically expressed in the prostate and over-expressed in prostate cancer. Kallikrein-5 is widely expressed but found at high levels in skin, breast, brain and testis; over-expression is an indicator of poor prognosis in ovarian cancer. Kallikrein-8 is expressed in the brain and is a novel marker of ovarian and cervical cancer.Human plasma kallikrein, a serine protease, is synthesized in the liver and circulates in the plasma bound to high molecular weight (HMW) kininogen or as a free zymogen. Once activated by its physiological activator, coagulation factor XII, it displays endopeptidase activity towards peptide bonds after arginine (preferred) and lysine. It cleaves HMW kininogen, its major physiological substrate, to release the potent vasodilator peptide bradykinin. It is also able to cleave a number of inactive precursor proteins to generate active products, such as plasminogen and prourokinase.
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Citations
Citations of cell biology reagents in peer reviewed literature can be used as a direct measure of product quality. They can also provide crucial insightinto their use under specialized or unique experimental conditions. Because of the importance published citations have to researchers, R&D Systems personnelmanually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but alsoprovides information about sample types, species, and experimental conditions.
Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome.
Bey AL, Masedunskas A, Sales KU
Nat. Genet. 2010 42:676-83
Species: Human
Protein Application: Bioassay
Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases.
Bartels J, Fischer J, Glaser R, Hansmann B, He Y, Kantyka T, Latendorf T, Meyer-Hoffert U, Schroder JM, Wu Z
J. Biol. Chem. 2010 285:32174-81
Species: Human
Protein Application: Enzyme Assay
Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.
Gallo RL, Kabigting FD, Morizane S, Yamasaki K
J. Invest. Dermatol. 2010 130:1297-306
Species: N/A
Protein Application: ELISA Standard
Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases.
Abraham WM, Chen J, Chen T, Forteza RM, Kuang G, Kuzmic P, Martik D, Nixon AE, Sexton DJ, Wood CR, Zuraw BL
Biochem. J. 2009 422:383-92
Species: Human
Protein Application: Surface Plasmon Resonance
Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases.
Fukushima T, Kataoka H, Mukai S, Naka D, Osada Y, Tanaka H
FEBS J. 2008 275:1003-17
Species: Human
Protein Application: Enzyme Activity
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea.
Bardan A, Bonnart C, Coda A, Descargues P, Di Nardo A, Dorschner RA, Gallo RL, Hovnanian A, Morhenn VB, Murakami M, Ohtake T, Yamasaki K
Nat. Med. 2007 13:975-80
Species: Mouse
Protein Application: In Vivo
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