抗Complement C3d抗体(Anti-Complement C3d, Goat-Poly antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Mouse
Label	Unconjugated
Immunogen	E. coli-derived recombinant mouse Complement Component C3dHis1002-Arg1303 (Cys1010Ser)Accession # P01027
Source	Polyclonal Goat IgG
Purification	Antigen Affinity-purified
Specificity	Detects mouse Complement Component C3d in direct ELISAs and Western blots.

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Applications and Data

	Recommended Concentration	Sample
Western Blot	0.1 µg/mL	Recombinant Mouse Complement Component C3d
Immunohistochemistry	5-15 µg/mL	See below

Immunohistochemistry

Complement Component C3d in Mouse Kidney. Complement Component C3d was detected in perfusion fixed frozen sections of mouse kidney using Goat Anti-Mouse Complement Component C3d Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2655) overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to basement membrane. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

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Related Product & Information

Entrez Gene IDs	718 (Human)
Background	Complement Component C3d
background_content	Background: Complement Component C3d

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Citations

1. C3d regulates immune checkpoint blockade and enhances antitumor immunity
   Authors: JL Platt, I Silva, SJ Balin, AR Lefferts, E Farkash, TM Ross, MC Carroll, M Cascalho
   JCI Insight, 2017;2(9):.
   Species: Mouse
   Sample Type: Cell Lysates
   Application: WB


2. Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium.
   Authors: Li Y, Song D, Song Y, Zhao L, Wolkow N, Tobias J, Song W, Dunaief J
   J Biol Chem, 2015;290(19):11918-34.
   Species: Human
   Sample Type: Whole Tissue
   Application: IHC Paraffin-embedded


3. The epidermal growth factor receptor is a regulator of epidermal complement component expression and complement activation.
   Authors: Abu-Humaidan A, Ananthoju N, Mohanty T, Sonesson A, Alberius P, Schmidtchen A, Garred P, Sorensen O
   J Immunol, 2014;192(7):3355-64.
   Species: Mouse
   Sample Type: Whole Cells
   Application: ICC


4. Targeting complement component 5a promotes vascular integrity and limits airway remodeling.
   Authors: Khan M, Maasch C, Vater A, Klussmann S, Morser J, Leung L, Atkinson C, Tomlinson S, Heeger P, Nicolls M
   Proc Natl Acad Sci U S A, 2013;110(15):6061-6.
   Species: Mouse
   Sample Type: Whole Tissue
   Application: IHC OCT-embedded


5. Soluble CR1 therapy improves complement regulation in C3 glomerulopathy.
   Authors: Zhang Y, Nester C, Holanda D, Marsh H, Hammond R, Thomas L, Meyer N, Hunsicker L, Sethi S, Smith R
   J Am Soc Nephrol, 2013;24(11):1820-9.
   Species: Mouse
   Sample Type: Whole Tissue
   Application: IHC


6. Donor brain death exacerbates complement-dependent ischemia/reperfusion injury in transplanted hearts.
   Authors: Atkinson, Carl, Floerchinger, Bernhard, Qiao, Fei, Casey, Sarah, Williamson, Tucker, Moseley, Ellen, Stoica, Serban, Goddard, Martin, Ge, Xupeng, Tullius, Stefan G, Tomlinson, Stephen
   Circulation, 2013;127(12):1290-9.
   Species: Mouse
   Sample Type: Whole Tissue
   Application: IHC Paraffin-embedded


7. The alternative complement pathway propagates inflammation and injury in murine ischemic stroke.
   Authors: Elvington, Andrew, Atkinson, Carl, Zhu, Hong, Yu, Jin, Takahashi, Kazue, Stahl, Gregory, Kindy, Mark S, Tomlinson, Stephen
   J Immunol, 2012;189(9):4640-7.
   Species: Mouse
   Sample Type: Whole Tissue
   Application: IHC Paraffin-embedded


8. Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice.
   Authors: Elvington A, Atkinson C, Kulik L
   J. Immunol., 2012;188(3):1460-8.
   Species: Mouse
   Sample Type: Whole Tissue
   Application: IHC Frozen


9. Age-related retinopathy in NRF2-deficient mice.
   Authors: Zhao Z, Chen Y, Wang J
   PLoS ONE, 2011;6(4):e19456.
   Species: Mouse
   Sample Type: Whole Tissue
   Application: IHC Frozen


10. Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice.
    Authors: Leung VW, Yun S, Botto M, Mason JC, Malik TH, Song W, Paixao-Cavalcante D, Pickering MC, Boyle JJ, Haskard DO
    Am. J. Pathol., 2009;175(4):1757-67.
    Species: Mouse
    Sample Type: Serum
    Application: ELISA Development

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