抗RhoA (Y486)抗体 | Anti-RhoA (Y486) Antibody

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Image

	Western Blot: RhoA Antibody (Y486) [NB110-57464] - Detection of RhoA on Human MDA-MB-231 cells using NB110-57464 at a dilution of 1:5000. Photo courtesy of a product review by verified customer.
	Immunohistochemistry: RhoA Antibody (Y486) [NB110-57464] - Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using anti-Rho (cat. # 110-57464).
	Western Blot: RhoA Antibody (Y486) [NB110-57464] - PC12 cell lysate.

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Background

Rho belongs to the Ras super family of low molecular weight GTPases. Fifteen Rho proteins have already been characterized and divided into three sub-families; the first includes Rho (A, B, C), the second, Rnd 1-3 and the third which includes Rac 1-3, RhoG, Cdc42Hs, Rho/TTF. TC10 and Chp (1-2). Rho acts as a molecular switch which turns on of off various intracellular signaling pathways such as ACK, PAKs, MEKKs ROCK (3). Rho is active when bound to GTP and inactive when bound to GDP (4). It is also known to participate in many physiological activities including cell migration, adhesion, cytokinesis, proliferation, differentiation and apoptosis and to a greater extend cell transformation (5).

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