抗TGF-beta RII抗体 | Anti-TGF-beta RII Antibody

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価格

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Image

	Western Blot: TGF-beta RII Antibody [NB100-91994] - Analysis of TGF BETA Receptor II (I122) pAb in extracts from HepG2 cells(65K) or LOVO cells(100K).
	Immunohistochemistry-Frozen: TGF-beta RII Antibody [NB100-91994] - Mouse frozen spinal cord tissue stained with TGF-beta RII antibody (green). Cells nuclei were counterstained with DAPI (blue). Image from verified customer review.
	Western Blot: TGF-beta RII Antibody [NB100-91994] - Analysis of TGF-beta RII (I122) pAb at 1:500 dilution Lane1:Hela whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate
	Simple Western: TGF-beta RII Antibody [NB100-91994] - Simple Western lane views show a specific band for TGF-beta RII (116 kDa) in mouse Ba/F3 (haematopoietic) cells. Image submitted by Dr. Ron Blance at The University of Manchester.

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Background

A total of three members of the TGFbeta family, TGFbeta1, TGFbeta2 and TGFbeta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor (TGFbeta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFbeta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFbeta type I receptor proteins designated ALK-5 (TbetaR-1) and TSR-1, respectively.

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