Decitabine-15N4

• 価格
• 構造式
• 製品情報
• 製品詳細
• 文献

価格

目次に戻る

構造式

目次に戻る

製品情報

Decitabine-¹⁵N₄ is intended for use as an internal standard for the quantification of decitabine (Item No. 11166). Decitabine is a 2’-deoxy analog of 5-azacytidine (Item No. 11164) that induces dose-dependent inhibition of DNA methyltransferases and hypomethylation of DNA. This action is useful in conditions characterized by DNA hypermethylation, as is found in myelodysplastic syndromes.

目次に戻る

製品詳細

name	Decitabine-15N4
Formal Name	4-(amino-15N)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one-1,3,5-15N3
Synonyms	5-aza-2’-Deoxycytidine-15N4 DAC-15N4
Molecular Formula	C8H12[15N]4O4
Formula Weight	232.2
Purity	≥95%
Formulation	A solid
SMILES	O[C@H]1C[C@H]([15N]2C=[15N]C([15NH2])=[15N]C2=O)O[C@@H]1CO
InChI Code	InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1/i9+1,10+1,11+1,12+1
InChI Key	XAUDJQYHKZQPEU-SSDNLDPUSA-N
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
Stability	≥ 2 years

目次に戻る

文献

1. Esteller, M. Epigenetics in cancer. N. Engl. J. Med. 358, 1148-1159 (2008).

2. Lyko, F., and Brown, R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J. Natl. Cancer Inst. 97(20), 1498-1506 (2005).

3. Stresemann, C., Brueckner, B., Musch, T., et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66(5), 2794-2800 (2006).

4. Ornstein, M.C., and Sekeres, M.A. Combination strategies in myelodysplastic syndromes. Int. J. Hematol. 95, 26-33 (2012).

目次に戻る