抗Human Aldehyde Dehydrogenase 1-A1抗体(Anti-Human Aldehyde Dehydrogenase 1-A1 antibody)
掲載日情報：2018/11/26 現在Webページ番号：196326
Human Aldehyde Dehydrogenase 1-A1に対する抗体(Anti-Human Aldehyde Dehydrogenase 1-A1 )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2024年05月20日 19時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-Human Aldehyde Dehydrogenase 1-A1 MAb (Clone 703410) |
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Anti-Human Aldehyde Dehydrogenase 1-A1 MAb (Clone 703410) |
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[在庫・価格 ：2024年05月20日 19時35分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Human Aldehyde Dehydrogenase 1-A1 MAb (Clone 703410)
文献数： 0
- 商品コード：MAB5869
- メーカー：RSD
- 包装：100μg
- 価格：¥100,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
Anti-Human Aldehyde Dehydrogenase 1-A1 MAb (Clone 703410)
文献数： 0
- 商品コード：MAB5869-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
Simple Western対応抗体。※受注発注品。形状：溶液または凍結乾燥 別名：acetaldehyde dehydrogenase 1 クローン：703410 Genbank No： 216 Protein Accession No： P00352 |
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| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | IC,IHC,Simple Western,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
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Product Details
| Species Reactivity | Human |
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| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant human Aldehyde Dehydrogenase 1-A1/ALDH1-A1Ser2-Ser501Accession # P00352 |
| Source | Monoclonal Mouse IgG2B Clone # 703410 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human Aldehyde Dehydrogenase 1-A1/ALDH1-A1 in direct ELISAs and Western blots. In direct ELISAs, approximatly50% cross‑reactivity with recombinant human Aldehyde Dehydrogenase 1-A2 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 2 µg/mL | See below |
| Simple Western | 20 µg/mL | See below |
| Immunohistochemistry | 8-25 µg/mL | See below |
| CyTOF-reported | Brodie, T.M. et al. (2018) Cytometry PartA. 93: 406. Ready to be labeled using establishedconjugation methods. No BSA or other carrier proteins that could interfere withconjugation. | |
| Immunocytochemistry | 8-25 µg/mL | See below |
| Immunocytochemistry | |
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 | Aldehyde Dehydrogenase 1‑A1/ALDH1A1 in A549 Human Cell Line. Aldehyde Dehydrogenase 1‑A1/ALDH1A1 was detected in immersion fixed A549 human lung carcinoma cell line using Mouse Anti-Human Aldehyde Dehydrogenase 1‑A1/ALDH1A1 Monoclonal Antibody (Catalog # MAB5869) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips. |
| Immunohistochemistry | |
 | Aldehyde Dehydrogenase 1‑A1/ALDH1A1 in Human Brain. Aldehyde Dehydrogenase 1‑A1/ALDH1A1 was detected in immersion fixed paraffin-embedded sections of human brain (substantia nigra) using Mouse Anti-Human Aldehyde Dehydrogenase 1‑A1/ALDH1A1 Monoclonal Antibody (Catalog # MAB5869) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to neurons. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
| Simple Western | |
 | Detection of Human Aldehyde Dehydrogenase 1‑A1/ALDH1A1 by Simple WesternTM. Simple Western lane view shows lysates of human liver tissue, loaded at 0.2 mg/mL. A specific band was detected for Aldehyde Dehydrogenase 1‑A1/ALDH1A1 at approximately 58 kDa (as indicated) using 20 µg/mL of Mouse Anti-Human Aldehyde Dehydrogenase 1‑A1/ALDH1A1 Monoclonal Antibody (Catalog # MAB5869). This experiment was conducted under reducing conditions and using the12-230 kDa separation system. |
| Western Blot | |
 | Detection of Human, Mouse, and Rat Aldehyde Dehydrogenase 1‑A1/ALDH1A1 by Western Blot. Western blot shows lysates of human liver tissue, mouse liver tissue, and rat lung tissue. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human Aldehyde Dehydrogenase 1‑A1/ALDH1A1 Monoclonal Antibody (Catalog # MAB5869) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Aldehyde Dehydrogenase 1‑A1/ALDH1A1 at approximately 54 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1. |
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Related Product & Information
| Background | Aldehyde Dehydrogenase 1-A1/ALDH1A1 |
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| background_content | Background: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Aldehyde dehydrogenases (ALDHs) are NAD(P)+-dependent enzymes that detoxify aldehydes by oxidizing them to carboxylic acids. Nineteen ALDHs are present in humans, expressed in a variety of organelles and having different substrate preferences (1). ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid (2). ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea (3). ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development (4). The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells (5). ALDH1A1 is a major enzyme in the oxidation of acetaldehyde, a toxic metabolite of ethanol (6). |
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