抗Mouse G-CSF抗体(Anti-Mouse G-CSF antibody)
掲載日情報：2021/01/28 現在Webページ番号：177345
Mouse G-CSFに対する抗体(Anti-Mouse G-CSF )です。
※ 本製品は研究用です。研究用以外には使用できません。
追加しました。
- 価格
- Product Details
- Applications and Data
- Data Examples
- Related Research Areas
- Summary
- Related Product & Information
- Citations
価格
[在庫・価格 ：2024年06月11日 00時00分現在]
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Anti-Mouse G-CSF MAb (Clone 67604) |
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Anti-Mouse G-CSF MAb (Clone 67604) |
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Anti-Mouse G-CSF MAb (Clone 67604) |
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[在庫・価格 ：2024年06月11日 00時00分現在]
Anti-Mouse G-CSF MAb (Clone 67604)
文献数： 3
- 商品コード：MAB414-100
- メーカー：RSD
- 包装：100μg
- 価格：¥101,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
別名：C17orf33 クローン：67604 Genbank No： 1440 Protein Accession No： P09920 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 |
M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） |
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| 関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse G-CSF MAb (Clone 67604)
文献数： 3
- 商品コード：MAB414-500
- メーカー：RSD
- 包装：500μg
- 価格：¥232,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
マッチドペア：Mouse G-CSF サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF414，スタンダードとして#414-CS-005を用いる。 別名：C17orf33 クローン：67604 Genbank No： 1440 Protein Accession No： P09920 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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||||||
| 製品記事 |
M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） |
||||||
| 関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Mouse G-CSF MAb (Clone 67604)
文献数： 3
- 商品コード：MAB414-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
※受注発注品。形状：溶液または凍結乾燥 別名：C17orf33 クローン：67604 Genbank No： 1440 Protein Accession No： P09920 |
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|---|---|---|---|---|---|---|---|
| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | 免疫動物 | Rat | |||||
| 交差性 | Mouse | 適用 | ELISA,Neutralising,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
|
||||||
| 製品記事 |
M1/M2 Macrophage Activation Marker 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） |
||||||
| 関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
||||||
追加しました。
Product Details
| Species Reactivity | Mouse |
|---|---|
| Label | Unconjugated |
| Immunogen | E. coli-derived recombinant mouse G-CSFVal31-Ala208Accession # P09920 |
| Source | Monoclonal Rat IgG1 Clone # 67604 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects mouse G-CSF in ELISAs and Western blots. In ELISAs, does not cross-react with recombinant human (rh) G‑CSF, rhCNTF, rmIL-6, rmLIF, or rmOSM. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 1 µg/mL | Recombinant Mouse G-CSF (Catalog # 414-CS) |
| Mouse G-CSF Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Mouse G‑CSF Antibody (Catalog #MAB414 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Mouse G‑CSF Biotinylated Antibody (Catalog #BAF414 ) |
| ELISA Standard | Recombinant Mouse G-CSF Protein (Catalog #414-CS ) | |
| Neutralization | Measured by its ability to neutralize G‑CSF-induced proliferation in the NFS‑60 mouse myeloid cells line. Shirafuji, N. et al. (1989) Exp. Hematol. 17:116. The Neutralization Dose (ND50) is typically 0.01-0.03 µg/mL in the presence of 0.125 ng/mL Recombinant Mouse G‑CSF. | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | ||
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Data Examples
| Neutralization |
![Neutralization G-CSF Antibody (67604) [Unconjugated]](http://resources.rndsystems.com/images/datasheets/antibody/G-CSF_MAB414_Block_Neutralize_9188.jpg) click image to view larger | Cell Proliferation Induced by G‑CSF and Neutralization by Mouse G‑CSF Antibody. Recombinant Mouse G‑CSF (Catalog # 414-CS) stimulates proliferation in the NFS‑60 mouse myeloid cells line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse G‑CSF (0.125 ng/mL) is neutralized (green line) by increasing concentrations of Mouse G‑CSF Monoclonal Antibody (Catalog # MAB414). The ND50 is typically 0.01-0.03 µg/mL. |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: G-CSF | G-CSF is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-alpha and IFN-gamma. Other cell types including fibroblasts, endothelial cells, astrocytes and bone marrow stromal cells can also secrete G-CSF after LPS, IL-1, or TNF-alpha activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. The murine G-CSF cDNA encodes a 208 amino acid (aa) residue precursor protein containing a 30 aa residue signal peptide that is proteolytically cleaved to generate the 178 aa residue mature protein. Human G-CSF is 73% identical at the amino acid level to murine G-CSF and the two proteins show species cross-reactivity. In vitro, G-CSF stimulates growth, differentiation and functions of cells from the neutrophil lineage. It also has blast cell growth factor activity and can synergize with IL-3 to shorten the Go period of early hematopoietic progenitors. Consistent with its in vitro functions, G-CSF has been found to play important roles in defense against infection, in inflammation and repair, and in the maintenance of steady state hematopoiesis. Recombinant human G-CSF has been approved for the amelioration of chemotherapy induced neutropenia as well as for severe chronic neutropenia following marrow transplant. |
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| Long Name: | Granulocyte Colony Stimulating Factor | |
| Entrez Gene IDs: | 1440 (Human); 12985 (Mouse) | |
| Alternate Names: | C17orf33; chromosome 17 open reading frame 33; colony stimulating factor 3 (granulocyte); CSF3; CSF3OS; Filgrastim; GCSF; G-CSF; GCSFlenograstim; granulocyte colony-stimulating factor; Lenograstim; MGC45931; pluripoietin | |
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Related Research Areas
| ALS Related Molecules | ||||||||
| Cytokines and Receptors in Angiogenesis | ||||||||
| Gametes and Fertilization | ||||||||
| IL-6 Family | ||||||||
| Macrophage Activation Markers | ||||||||
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| Images | Ratings | Applications | Species | Reviewed By | Date | Details | ||
|---|---|---|---|---|---|---|---|---|
| Excellent | IHC | Mouse | Anonymous | 04/13/2018 | ||||
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Summary
| Application | Immunohistochemistry |
| Sample Tested | Serum |
| Species | Mouse |
| Neutralization | |
|---|---|
 | Cell Proliferation Induced by G‑CSF and Neutralization by Mouse G‑CSF Antibody. Recombinant Mouse G‑CSF (Catalog # 414-CS) stimulates proliferation in the NFS‑60 mouse myeloid cells line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse G‑CSF (0.125 ng/mL) is neutralized (green line) by increasing concentrations of Mouse G‑CSF Monoclonal Antibody (Catalog # MAB414). The ND50 is typically 0.01-0.03 µg/mL. |
追加しました。
Related Product & Information
| Long Name | Granulocyte Colony Stimulating Factor |
|---|---|
| Entrez Gene IDs | 1440 (Human); 12985 (Mouse) |
| Background | G-CSF |
| background_content | Background: G-CSF G-CSF is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-alpha and IFN-gamma. Other cell types including fibroblasts, endothelial cells, astrocytes and bone marrow stromal cells can also secrete G-CSF after LPS, IL-1, or TNF-alpha activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. The murine G-CSF cDNA encodes a 208 amino acid (aa) residue precursor protein containing a 30 aa residue signal peptide that is proteolytically cleaved to generate the 178 aa residue mature protein. Human G-CSF is 73% identical at the amino acid level to murine G-CSF and the two proteins show species cross-reactivity. In vitro, G-CSF stimulates growth, differentiation and functions of cells from the neutrophil lineage. It also has blast cell growth factor activity and can synergize with IL-3 to shorten the Go period of early hematopoietic progenitors. Consistent with its in vitro functions, G-CSF has been found to play important roles in defense against infection, in inflammation and repair, and in the maintenance of steady state hematopoiesis. Recombinant human G-CSF has been approved for the amelioration of chemotherapy induced neutropenia as well as for severe chronic neutropenia following marrow transplant. |
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Citations
- Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection
Authors: F Sparber, T Dolowschia, S Mertens, L Lauener, BE Clausen, N Joller, P Stoitzner, R Tussiwand, S LeibundGut
PLoS Pathog., 2018;14(5):e1007069.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo - Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
Authors: MA Meyer, JM Baer, BL Knolhoff, TM Nywening, RZ Panni, X Su, KN Weilbaeche, WG Hawkins, C Ma, RC Fields, DC Linehan, GA Challen, R Faccio, RL Aft, DG DeNardo
Nat Commun, 2018;9(1):1250.
Species: Mouse
Sample Type: In Vivo
Application: Neut - Granulocyte colony-stimulating factor blockade enables dexamethasone to inhibit lipopolysaccharide-induced murine lung neutrophils
Authors: J Banuelos, Y Cao, SC Shin, BS Bochner, P Avila, S Li, X Jiang, MW Lingen, RP Schleimer, NZ Lu
PLoS ONE, 2017;12(5):e0177884.
Species: Mouse
Sample Type: In Vivo
Application: Neut - Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis
Authors: H Zhu, HJ Kwak, P Liu, B Bajrami, Y Xu, SY Park, C Nombela-Ar, S Mondal, H Kambara, H Yu, L Chai, LE Silberstei, T Cheng, HR Luo
J. Immunol, 2017;0(0):.
Species: Mouse
Sample Type: In Vivo
Application: In vivo - The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
Cell, 2016;0(0):.
Species: Mouse
Sample Type: In Vivo
Application: In vivo - Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis
Authors: Arna E Andrews
J. Immunol., 2016;0(0):.
Species: Mouse
Sample Type: In Vivo
Application: In vivo - Role of G-CSF in monophosphoryl lipid A-mediated augmentation of neutrophil functions after burn injury.
Authors: Bohannon J, Luan L, Hernandez A, Afzal A, Guo Y, Patil N, Fensterheim B, Sherwood E
J Leukoc Biol, 2016;99(4):629-40.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo - Tumor-secreted products repress B-cell lymphopoiesis in a murine model of breast cancer
Eur J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Neut - An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection
Authors: Anna A Müller
PLoS Pathog, 2016;12(6):e1005723.
Species: Mouse
Sample Type: In Vivo
Application: In vivo - Depletion of CD11c(+) cells in the CD11c.DTR model drives expansion of unique CD64(+) Ly6C(+) monocytes that are poised to release TNF-alpha.
Authors: Sivakumaran S, Henderson S, Ward S, Santos E Sousa P, Manzo T, Zhang L, Conlan T, Means T, D'Aveni M, Hermine O, Rubio M, Chakraverty R, Bennett C
Eur J Immunol, 2016;46(1):192-203.
Species: Mouse
Sample Type: In Vivo
Application: Neut
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