Plumbagin (5-Hydroxy-2-methyl-1,4-naphthalenedione) | 481-42-5

name

plumbagin

chemical name

5-hydroxy-2-methyl-1,4-naphthalenedione

activity

anticancer agent. induces g2/m cell cycle arrest and apoptosis in a549 cells through jnk-dependent p53 ser15 phosphorylation; inhibits a549 and mda-md-231 tumour xenograft growth in nude mice. promotes autophagic cell death in mda-mb-231 and mcf-7 cells and inhibits akt/mtor signaling. induces intracellular ros generation in a pi 5-kinase-dependent manner.

MW

188.18

Formula:

c11h8o3

Solubility:

soluble to 100 mm in dmso and to 50 mm in ethanol

Purity:

>98 %

Storage:

store at -20°c

CAS No:

481-42-5

Hsu et al (2006) Plumbagin (5-hydroxy-2-methyl-1,4-napthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH₂-terminal kinase mediated phosphorylation at serine 15 in vitro and in vivo. J.Pharmacol.Exp.Ther. 318 484. PMID: 16632641.

Kuo et al (2006) Plumbagin induces G₂-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol.Cancer Ther. 5 3209. PMID: 17172425.

Lee et al (2012) The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation. PLoS One. 7 e45023. PMID: 23028742.