Animal-Free Recombinant Murine GM-CSF

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• 製品詳細
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価格

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製品詳細

name	Animal-Free Recombinant Murine GM-CSF
Source	E.coli
Synonyms	Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α
AA Sequence	MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Description	GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Murine GM-CSF is a 14.2 kDa globular protein consisting of 125 amino acid residues.
Cross Reactivity	Mouse, N/A, Rat, Trout

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画像

Animal-Free Recombinant Murine GM-CSF Biological Activity Graph

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文献

1. First Author:Imai, K
   Title:Inhibition of dendritic cell migration by transforming growth factor-b1 increases tumor-draining lymph node metastasis
   Citation:Journal of Experimental & Clinical Cancer Research; 31:3
   
2. First Author:Li, R
   Title:Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis.
   Citation:Journal of Translational Medicine; 10:19
   
3. First Author:Yeang, H X
   Title:Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.
   Citation:The Journal of Biological Chemistry; 287(13):10556-6
   
4. First Author:Joshi, N
   Title:Adjuvant properties of thermal component of hyperthermia enhanced transdermal immunization: effect on dendritic cells.
   Citation:PLoS ONE; 7(2):e32067
   
5. First Author:Bassity, E
   Title:Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss).
   Citation:PLoS ONE; 7(3):e33196
   
6. First Author:Geng, S
   Title:Amiloride enhances antigen specific CTL by faciliting HBV DNA vaccine entry into cells.
   Citation:PLoS ONE; 7(3):e33015
   
7. First Author:Kitamura, H
   Title:Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.
   Citation:The Journal of Immunology; 188(9):4200-8
   
8. First Author:Van, V Q
   Title:CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.
   Citation:The Journal of Immunology; 188(9):4249-55
   
9. First Author:Fukui, R
   Title:Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.
   Citation:Immunity; 35(1):69-81
   
10. First Author:Jeong, H W
    Title:Mind Bomb-1 in Dendritic Cells Is Specifically Required for Notch-mediated T Helper Type 2 Differentiation.
    Citation:PLoS ONE; 7(4):e36359
    

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