抗FUS抗体 (Anti-FUS Antibody) | ヒト組織免疫染色用抗体
掲載日情報：2019/10/28 現在Webページ番号：11382
FUSに対する抗体(Anti-FUS Antibody)です。
高品質なTriple A Polyclonalsブランド抗体となります。
※本製品は研究用です。研究用以外には使用できません。
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特長
- Atlas Antibodies社のポリクローナル抗体は「Atlas Antibodies Advanced Polyclonals」(Triple A Polyclonals)と称され、Atlas Antibodies社企業秘密のソフトウェアにより対象抗原タンパク質に対する最も適した、慎重にデザインされた抗体です。
- アフィニティーリガンドとしてリコンビナント抗原を用いた、Atlas Antibodies社独自の抗原精製過程により、特異性・信頼性・多様性が保持されています。
- 対応するリコンビナント抗原の取り扱いもあり(PrEST抗原)、ウエスタンブロット用のポジティブコントロール、および免疫組織染色での抗体ブロッキングに有用です。
- すべての抗体はHuman Protein Atlas (HPA) プロジェクトにて、様々な正常組織、腫瘍組織で検証されています。
- それぞれの抗体に対して700点以上の免疫組織染色、免疫蛍光染色、ウエスタンブロッティング像が公開されています。
Triple A Polyclonalsとは？
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価格
[在庫・価格 ：2024年04月29日 09時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-FUS, Rabbit-Poly <Anti-ALS6> |
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[在庫・価格 ：2024年04月29日 09時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-FUS, Rabbit-Poly <Anti-ALS6>
文献数： 13
- 商品コード：HPA008784
- メーカー：AAB
- 包装：100μl
- 価格：¥96,000
- 在庫：無(未発注)
- 納期：2週間程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
※マウス・ラットへの交差性はウエスタンブロットのみで確認されています。免疫組織染色での反応性を保証するものではありませんのでご注意下さい。バリデーション情報：GENETIC, ORTHOGONAL, STANDARD 別名：ALS6，FUS1，hnRNP-P2，HNRNPP2，TLS Genbank No： 2521 Protein Accession No： P35637 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | -20℃ | 法規備考 | |||||
| 抗原種 | Human | 免疫動物 | Rabbit | ||||
| 交差性 | Human/Mouse/Rat | 適用 | IC,IHC,Western Blot | ||||
| 標識 | Unlabeled | 性状 | Antigen Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Polyclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 |
Atlas Antibodies社における抗体検証の取り組み |
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製品情報
免疫組織染色(IHC)  | Immunohistochemical staining of human liver shows moderate nuclear positivity in bile duct cells while hepatocytes are negative. 推奨プロトコル(Recommended conditions) |
ウエスタンブロッティング(WB)  | Western blot analysis in mouse cell line NIH-3T3 and rat cell line NBT-II. 推奨プロトコル(Recommended conditions) |
免疫蛍光染色(IF)  | Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm. Antibody staining is shown in green. 推奨プロトコル(Recommended conditions) |
関連データベース(Database Links)
抗原情報(Antigen Sequence)
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: : SSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDR
抗体の精製方法(Purification Method)
Affinity purified using the PrEST antigen as affinity ligand
ホモロジー情報(Interspecies Information)
性状(Form)
40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
保存方法(Storage)
Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Notes
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
References
Title
An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
Source
EMBO J
Mateju D, Franzmann TM, Patel A, Kopach A, Boczek EE, Maharana S, Lee HO, Carra S, Hyman AA, Alberti S.
An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
Source
EMBO J
Mateju D, Franzmann TM, Patel A, Kopach A, Boczek EE, Maharana S, Lee HO, Carra S, Hyman AA, Alberti S.
Title
Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration
Source
Acta Neuropathol Commun
Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H.
Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration
Source
Acta Neuropathol Commun
Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H.
Title
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons
Source
Front Cell Neurosci
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM.
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons
Source
Front Cell Neurosci
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM.
Title
Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia
Source
Acta Neuropathol Commun
Ziskin JL, Greicius MD, Zhu W, Okumu AN, Adams CM, Plowey ED.
Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia
Source
Acta Neuropathol Commun
Ziskin JL, Greicius MD, Zhu W, Okumu AN, Adams CM, Plowey ED.
Title
Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1
Source
Proc Natl Acad Sci U S A
Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S.
Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1
Source
Proc Natl Acad Sci U S A
Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S.
Title
A truncating SOD1 mutation, p.Gly141X, is associated with clinical and pathologic heterogeneity, including frontotemporal lobar degeneration
Source
Acta Neuropathol
Nakamura M, Bieniek KF, Lin WL, Graff-Radford NR, Murray ME, Castanedes-Casey M, Desaro P, Baker MC, Rutherford NJ, Robertson J, Rademakers R, Dickson DW, Boylan KB.
A truncating SOD1 mutation, p.Gly141X, is associated with clinical and pathologic heterogeneity, including frontotemporal lobar degeneration
Source
Acta Neuropathol
Nakamura M, Bieniek KF, Lin WL, Graff-Radford NR, Murray ME, Castanedes-Casey M, Desaro P, Baker MC, Rutherford NJ, Robertson J, Rademakers R, Dickson DW, Boylan KB.
Title
Familial Behavioral Variant Frontotemporal Dementia Associated With Astrocyte-Predominant Tauopathy
Source
J Neuropathol Exp Neurol
Ferrer I, Legati A, García-Monco JC, Gomez-Beldarrain M, Carmona M, Blanco R, Seeley WW, Coppola G.
Familial Behavioral Variant Frontotemporal Dementia Associated With Astrocyte-Predominant Tauopathy
Source
J Neuropathol Exp Neurol
Ferrer I, Legati A, García-Monco JC, Gomez-Beldarrain M, Carmona M, Blanco R, Seeley WW, Coppola G.
Title
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant
Source
Acta Neuropathol Commun
Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R.
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant
Source
Acta Neuropathol Commun
Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R.
Title
Activity-dependent FUS dysregulation disrupts synaptic homeostasis
Source
Proc Natl Acad Sci U S A
Sephton CF, Tang AA, Kulkarni A, West J, Brooks M, Stubblefield JJ, Liu Y, Zhang MQ, Green CB, Huber KM, Huang EJ, Herz J, Yu G.
Activity-dependent FUS dysregulation disrupts synaptic homeostasis
Source
Proc Natl Acad Sci U S A
Sephton CF, Tang AA, Kulkarni A, West J, Brooks M, Stubblefield JJ, Liu Y, Zhang MQ, Green CB, Huber KM, Huang EJ, Herz J, Yu G.
Title
Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease
Source
Am J Neurodegener Dis
Nakamura M, Murray ME, Lin WL, Kusaka H, Dickson DW.
Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease
Source
Am J Neurodegener Dis
Nakamura M, Murray ME, Lin WL, Kusaka H, Dickson DW.
Title
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects
Source
J Clin Invest
Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ.
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects
Source
J Clin Invest
Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ.
Title
Frontotemporal dementia–amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1–q12.2: genetic, clinical and neuropathological analysis
Source
Acta Neuropathol
Dobson-Stone C, Luty AA, Thompson EM, Blumbergs P, Brooks WS, Short CL, Field CD, Panegyres PK, Hecker J, Solski JA, Blair IP, Fullerton JM, Halliday GM, Schofield PR, Kwok JB.
Frontotemporal dementia–amyotrophic lateral sclerosis syndrome locus on chromosome 16p12.1–q12.2: genetic, clinical and neuropathological analysis
Source
Acta Neuropathol
Dobson-Stone C, Luty AA, Thompson EM, Blumbergs P, Brooks WS, Short CL, Field CD, Panegyres PK, Hecker J, Solski JA, Blair IP, Fullerton JM, Halliday GM, Schofield PR, Kwok JB.
Title
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS
Source
EMBO J
Dormann D, Madl T, Valori CF, Bentmann E, Tahirovic S, Abou-Ajram C, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C.
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS
Source
EMBO J
Dormann D, Madl T, Valori CF, Bentmann E, Tahirovic S, Abou-Ajram C, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C.
Title
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations
Source
Brain
Snowden JS, Rollinson S, Thompson JC, Harris JM, Stopford CL, Richardson AM, Jones M, Gerhard A, Davidson YS, Robinson A, Gibbons L, Hu Q, DuPlessis D, Neary D, Mann DM, Pickering-Brown SM.
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations
Source
Brain
Snowden JS, Rollinson S, Thompson JC, Harris JM, Stopford CL, Richardson AM, Jones M, Gerhard A, Davidson YS, Robinson A, Gibbons L, Hu Q, DuPlessis D, Neary D, Mann DM, Pickering-Brown SM.
Title
Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistry.
Source
Cerebellum
Pikkarainen M, Hartikainen P, Soininen H, Alafuzoff I.
Distribution and pattern of pathology in subjects with familial or sporadic late-onset cerebellar ataxia as assessed by p62/sequestosome immunohistochemistry.
Source
Cerebellum
Pikkarainen M, Hartikainen P, Soininen H, Alafuzoff I.
Title
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
Source
Brain
Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IR.
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
Source
Brain
Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IR.
Title
A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies
Source
Brain
Lashley T, Rohrer JD, Bandopadhyay R, Fry C, Ahmed Z, Isaacs AM, Brelstaff JH, Borroni B, Warren JD, Troakes C, King A, Al-Saraj S, Newcombe J, Quinn N, Ostergaard K, Schrøder HD, Bojsen-Møller M, Braendgaard H, Fox NC, Rossor MN, Lees AJ, Holton JL, Revesz T.
A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies
Source
Brain
Lashley T, Rohrer JD, Bandopadhyay R, Fry C, Ahmed Z, Isaacs AM, Brelstaff JH, Borroni B, Warren JD, Troakes C, King A, Al-Saraj S, Newcombe J, Quinn N, Ostergaard K, Schrøder HD, Bojsen-Møller M, Braendgaard H, Fox NC, Rossor MN, Lees AJ, Holton JL, Revesz T.
Title
Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations
Source
Nucleic Acids Res
Kino Y, Washizu C, Aquilanti E, Okuno M, Kurosawa M, Yamada M, Doi H, Nukina N.
Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations
Source
Nucleic Acids Res
Kino Y, Washizu C, Aquilanti E, Okuno M, Kurosawa M, Yamada M, Doi H, Nukina N.
Title
FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration
Source
Acta Neuropathol
Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, The FReJA Consortium, Dickson DW, Rademakers R, Graff-Radford NR, Parisi JE, Petersen RC, Hatanpaa KJ, White III CL, Weiner MF, Geser F, Van Deerlin VM, Trojanowski JQ, Miller BL, Seeley WW, van der Zee J, Kumar-Singh S, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bigio EH, Deng HX, Halliday GM, Kril JJ, Munoz DG, Mann DM, Pickering-Brown SM, Doodeman V, Adamson G, Ghazi-Noori S, Fisher EM, Holton JL, Revesz T, Rossor MN, Collinge J, Mead S, Isaacs AM.
FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration
Source
Acta Neuropathol
Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, The FReJA Consortium, Dickson DW, Rademakers R, Graff-Radford NR, Parisi JE, Petersen RC, Hatanpaa KJ, White III CL, Weiner MF, Geser F, Van Deerlin VM, Trojanowski JQ, Miller BL, Seeley WW, van der Zee J, Kumar-Singh S, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bigio EH, Deng HX, Halliday GM, Kril JJ, Munoz DG, Mann DM, Pickering-Brown SM, Doodeman V, Adamson G, Ghazi-Noori S, Fisher EM, Holton JL, Revesz T, Rossor MN, Collinge J, Mead S, Isaacs AM.
Title
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis
Source
Ann Neurol
Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T.
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis
Source
Ann Neurol
Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T.
Title
Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration.
Source
J Neurol
Seelaar H, Klijnsma KY, de Koning I, van der Lugt A, Chiu WZ, Azmani A, Rozemuller AJ, van Swieten JC.
Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration.
Source
J Neurol
Seelaar H, Klijnsma KY, de Koning I, van der Lugt A, Chiu WZ, Azmani A, Rozemuller AJ, van Swieten JC.
Title
Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease
Source
Acta Neuropathol
Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IR.
Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease
Source
Acta Neuropathol
Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IR.
Title
A new subtype of frontotemporal lobar degeneration with FUS pathology
Source
Brain
Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR.
A new subtype of frontotemporal lobar degeneration with FUS pathology
Source
Brain
Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR.
Title
FUS pathology in basophilic inclusion body disease.
Source
Acta Neuropathol
Munoz DG, Neumann M, Kusaka H, Yokota O, Ishihara K, Terada S, Kuroda S, Mackenzie IR.
FUS pathology in basophilic inclusion body disease.
Source
Acta Neuropathol
Munoz DG, Neumann M, Kusaka H, Yokota O, Ishihara K, Terada S, Kuroda S, Mackenzie IR.
カートに商品を
追加しました。
追加しました。
抗原情報(Antigen Sequence)
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: : SSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDR[在庫・価格 ：2024年04月29日 09時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
| 詳細 | 商品名 |
|
文献数 | ||
|---|---|---|---|---|---|
|
PrEST Antigen FUS, Human, Recombinant |
|
0 | |||
[在庫・価格 ：2024年04月29日 09時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
PrEST Antigen FUS, Human, Recombinant
文献数： 0
- 商品コード：APrEST86697
- メーカー：AAB
- 包装：100μl
- 価格：¥56,000
- 在庫：無(未発注)
- 納期：ご照会下さい ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
カートに商品を
追加しました。
追加しました。
関連製品情報
高性能な免疫組織染色用の抗原賦活化装置： 「Decloaking Chamber NxGen」 ⇒ 詳細はこちら
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製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。
表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。