価格表

在庫・価格 : 2024年05月18日 05時11分 現在

商品名 商品コード メーカー 包装 価格 在庫 リスト
IL-6, Human, Recombinant
データシート
206-IL-050 RSDアールアンドディー システムス
R&D Systems, Inc.
50 μg ¥186,000 1個 追加

在庫・価格 : 2024年05月18日 05時11分 現在

IL-6, Human, Recombinant

  • 商品コード:206-IL-050
  • メーカー:RSD
  • 包装:50μg
  • 価格: ¥186,000
  • 在庫:1個
使用文献
No. 文献情報 備考 参照
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2 Shih CC et al. A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells. Blood 2000 Mar;95(6):1957-66
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3 Sennikov SV et al. Production of cytokines by immature erythroid cells derived from human embryonic liver. Eur. Cytokine Netw. ;12(2):274-9
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4 Derksen PW et al. Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma. Blood 2002 Feb;99(4):1405-10
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5 Hoshino Y et al. Maximal HIV-1 replication in alveolar macrophages during tuberculosis requires both lymphocyte contact and cytokines. J. Exp. Med. 2002 Feb;195(4):495-505
Hoshino Y et al
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6 Shi Y et al. Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6. J. Biol. Chem. 2002 May;277(18):15712-20
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7 Jeong HJ et al. Regulatory effect of cytokine production in asthma patients by SOOJI CHIM (Koryo Hand Acupuncture Therapy). Immunopharmacol Immunotoxicol 2002 May;24(2):265-74
Jeong HJ et al
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Application: ELISA Standard PubMed
8 Graff-Dubois S et al. Generation of CTL recognizing an HLA-A*0201-restricted epitope shared by MAGE-A1, -A2, -A3, -A4, -A6, -A10, and -A12 tumor antigens: implication in a broad-spectrum tumor immunotherapy. J. Immunol. 2002 Jul;169(1):575-80
Graff-Dubois S et al
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9 Paludan C et al. Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt"s lymphoma cells. J. Immunol. 2002 Aug;169(3):1593-603
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10 Beckebaum S et al. Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivo-generated DC1 in chronic hepatitis B infection. Clin. Immunol. 2002 Aug;104(2):138-50
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11 Manz MG et al. Prospective isolation of human clonogenic common myeloid progenitors. Proc. Natl. Acad. Sci. U.S.A. 2002 Sep;99(18):11872-7
Manz MG et al
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12 Cork BA et al. Expression of interleukin (IL)-11 receptor by the human endometrium in vivo and effects of IL-11, IL-6 and LIF on the production of MMP and cytokines by human endometrial cells in vitro. Mol. Hum. Reprod. 2002 Sep;8(9):841-8
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13 Tian C et al. Expression of antigen on mature lymphocytes is required to induce T cell tolerance by gene therapy. J. Immunol. 2002 Oct;169(7):3771-6
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14 Banu N et al. P-selectin, and not E-selectin, negatively regulates murine megakaryocytopoiesis. J. Immunol. 2002 Oct;169(8):4579-85
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15 Erices A et al. Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Exp. Cell Res. 2002 Oct;280(1):24-32
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16 Debes JD et al. p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6. Cancer Res. 2002 Oct;62(20):5632-6
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17 Romero L et al. Down-regulation of alpha class glutathione S-transferase by interleukin-1beta in human intestinal epithelial cells (Caco-2) in culture. Drug Metab. Dispos. 2002 Nov;30(11):1186-93
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18 Hurst SM et al. Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J. Immunol. 2002 Nov;169(9):5244-51
Hurst SM et al
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Application: ELISA Standard PubMed
19 Becker S et al. Involvement of microbial components and toll-like receptors 2 and 4 in cytokine responses to air pollution particles. Am. J. Respir. Cell Mol. Biol. 2002 Nov;27(5):611-8
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20 Tsai PW et al. Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway. J. Biol. Chem. 2003 Feb;278(8):5750-9
Tsai PW et al
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Application: Bioassay, Sample Type: Whole Cells PubMed
21 Steiner H et al. Accelerated in vivo growth of prostate tumors that up-regulate interleukin-6 is associated with reduced retinoblastoma protein expression and activation of the mitogen-activated protein kinase pathway. Am. J. Pathol. 2003 Feb;162(2):655-6
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Application: Bioassay, Sample Type: Cell Supernates PubMed
22 Hobbs RM et al. Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease. J. Biol. Chem. 2003 May;278(22):19798-807
Hobbs RM et al
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Application: Bioassay, Sample Type: Whole Cells PubMed
23 Zhang B et al. IL-6-independent expression of Mcl-1 in human multiple myeloma. Oncogene 2003 Mar;22(12):1848-59
Zhang B et al
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Application: Bioassay, Sample Type: Whole Cells PubMed
24 Grivel JC et al. Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo. J. Virol. 2003 Aug;77(15):8280-9
Grivel JC et al
2003/01/01
Application: ELISA Standard PubMed
25 McLoughlin RM et al. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest. 2003 Aug;112(4):598-607
McLoughlin RM et al
2003/01/01
Application: ELISA Standard PubMed
26 Percario Z et al. Human immunodeficiency virus type 1 (HIV-1) Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors: involvement of Nef domains interacting with the cell endocytotic machinery. J. Leukoc. Biol. 20
Percario Z et al
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Application: Bioassay, Sample Type: Whole Cells PubMed
27 Kellar KL et al. Multiplexed microsphere-based flow cytometric immunoassays for human cytokines. J. Immunol. Methods 2003 Aug;279(1-2):277-85
Kellar KL et al
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Application: Luminex Multiplex Development PubMed
28 Sastre M et al. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J. Neurosci. 2003 Oct;23(30):9796-80
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29 Rauser G et al. Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. Blood 2004 May;103(9):3565-72
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30 Baer PC et al. Effects of mycophenolic acid on IL-6 expression of human renal proximal and distal tubular cells in vitro. Nephrol. Dial. Transplant. 2004 Jan;19(1):47-52
Baer PC et al
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Application: ELISA Standard PubMed
31 Gazitt Y et al. Mobilization of myeloma cells involves SDF-1/CXCR4 signaling and downregulation of VLA-4. Stem Cells 2004;22(1):65-73
Gazitt Y et al
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Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
32 Copeland S et al. Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods 2004 Jan;284(1-2):99-106
Copeland S et al
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Application: ELISA Standard PubMed
33 S辿n辿chal B et al. Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83. Blood 2004 Jun;103(11):4207-15
S辿n辿chal B et al
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34 Lu SJ et al. CD34+CD38- hematopoietic precursors derived from human embryonic stem cells exhibit an embryonic gene expression pattern. Blood 2004 Jun;103(11):4134-41
Lu SJ et al
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Application: Bioassay, Sample Type: Whole Cells PubMed
35 Suzuki M et al. Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex. Proc. Natl. Acad. Sci. U.S.A. 2004 Mar;101(9):3202-7
Suzuki M et al
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36 Terui K et al. Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction. Biochem. J. 2004 May;380(Pt 1):203-9
Terui K et al
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37 Jeong HJ et al. The effect of acupuncture on proinflammatory cytokine production in patients with chronic headache: a preliminary report. Am. J. Chin. Med. 2003;31(6):945-54
Jeong HJ et al
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Application: ELISA Standard PubMed
38 Kerschner JE et al. Middle ear epithelial mucin production in response to interleukin-6 exposure in vitro. Cytokine 2004 Apr;26(1):30-6
Kerschner JE et al
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Species: Chinchilla, Application: Bioassay, Sample type: Whole Cells PubMed
39 Bas S et al. CD14 is an acute-phase protein. J. Immunol. 2004 Apr;172(7):4470-9
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40 Steiner H et al. An autocrine loop for vascular endothelial growth factor is established in prostate cancer cells generated after prolonged treatment with interleukin 6. Eur. J. Cancer 2004 May;40(7):1066-72
Steiner H et al
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Application: Neutralization, Sample Type: Whole Cells PubMed
41 Granelli-Piperno A et al. HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc. Natl. Acad. Sci. U.S.A. 2004 May;101(20):7669-74
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42 Cisco RM et al. Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. J. Immunol. 2004 Jun;172(11):7162-8
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43 Larsson M et al. Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus. J. Virol. 2004 Jun;78(12):6151-61
Larsson M et al
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44 McGuckin CP et al. Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells. Cell Prolif. 2004 Aug;37(4):295-306
McGuckin CP et al
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45 Wolk K et al. IL-22 increases the innate immunity of tissues. Immunity 2004 Aug;21(2):241-54
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46 Ogawa N et al. Expression of interferon-inducible T cell alpha chemoattractant (CXCL11) in the salivary glands of patients with Sjテθ津つカgren"s syndrome. Clin. Immunol. 2004 Sep;112(3):235-8
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47 Kao CY et al. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol. 2004 Sep;173(5):3482-91
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48 Pajusto M et al. Human in vivo-activated CD45R0(+) CD4(+) T cells are susceptible to spontaneous apoptosis that can be inhibited by the chemokine CXCL12 and IL-2, -6, -7, and -15. Eur. J. Immunol. 2004 Oct;34(10):2771-80
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49 Nagineni CN et al. Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol. 2005 Apr;203(1):35-43
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50 Couldrey C et al. A STAT5 modifier locus on murine chromosome 7 modulates engraftment of hematopoietic stem cells during steady-state hematopoiesis. Blood 2005 Feb;105(4):1476-83
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51 Ferlazzo G et al. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc. Natl. Acad. Sci. U.S.A. 2004 Nov;101(47):16606-11
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52 Mozaffarian D et al. trans fatty acids and systemic inflammation in heart failure. Am. J. Clin. Nutr. 2004 Dec;80(6):1521-5
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53 DeMarco RA et al. Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1. Mol. Immunol. 2005 Feb;42(4):433-44
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54 Putz T et al. Monitoring of CD4+ and CD8+ T-cell responses after dendritic cell-based immunotherapy using CFSE dye dilution analysis. J. Clin. Immunol. 2004 Nov;24(6):653-63
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55 Diveu C et al. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. Eur. Cytokine Netw. ;15(4):291-302
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56 Mandelin J et al. Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K. J. Rheumatol. 2005 Apr;32(4):713-20
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57 Guyot N et al. Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin. Biol. Chem. 2005 Apr;386(4):391-9
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58 Holst RM et al. Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery. Acta Obstet Gynecol Scand 200
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59 Hanley MB et al. Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells 2005 Sep;23(8):1170-9
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60 Militi S et al. Role of IL-6 and CD23 in the resistance to growth arrest and apoptosis in LCL41 B lymphoma cells. Cytokine 2005 Aug;31(4):314-23
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61 Hsieh FH et al. Human airway epithelial cell determinants of survival and functional phenotype for primary human mast cells. Proc. Natl. Acad. Sci. U.S.A. 2005 Oct;102(40):14380-5
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62 von Strandmann EP et al. A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo. Blood 2006 Mar;10
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2006/01/01
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63 Kao CY et al. Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. J. Immunol. 2005 Nov;175(10):6676-85
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64 Mortara L et al. Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes. J. Immunol. Methods 2006 Jan;308(1-2):138-55
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65 Yuan J et al. Langerhans-type dendritic cells genetically modified to express full-length antigen optimally stimulate CTLs in a CD4-dependent manner. J. Immunol. 2006 Feb;176(4):2357-65
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66 Gemelli C et al. Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells. Cell Death Differ. 2006 Oct;13(10):1686-96
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2006/01/01
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67 Pav坦n L et al. Th2 cytokine response in Major Depressive Disorder patients before treatment. J. Neuroimmunol. 2006 Mar;172(1-2):156-65
Pav坦n L et al
2006/01/01
Application: ELISA Standard PubMed
68 Ho WY et al. In vitro methods for generating CD8+ T-cell clones for immunotherapy from the naテδッve repertoire. J. Immunol. Methods 2006 Mar;310(1-2):40-52
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2006/01/01
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69 Decker WK et al. Double loading of dendritic cell MHC class I and MHC class II with an AML antigen repertoire enhances correlates of T-cell immunity in vitro via amplification of T-cell help. Vaccine 2006 Apr;24(16):3203-16
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70 Nencioni A et al. Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation. Blood 2006 Jul;108(2):551-8
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2006/01/01
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71 Kryczek I et al. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 2006 Apr;203(4):871-81
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72 H辰gg D et al. Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop? Atherosclerosis 2007 Feb;190(2):291-7
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2007/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
73 Fischer M et al. Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype. Blood 2006 Sep;108(6):2121-3
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2006/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
74 M辿ndez-Samperio P et al. Mycobacterium bovis Bacillus Calmette-Guérin (BCG) stimulates human beta-defensin-2 gene transcription in human epithelial cells. Cell. Immunol. 2006 Jan;239(1):61-6
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75 Truksa J et al. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc. Natl. Acad. Sci. U.S.A. 2006 Jul;103(27):10289-93
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2006/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
76 Wadle A et al. Cross-presentation of HLA class I epitopes from influenza matrix protein produced in Saccharomyces cerevisiae. Vaccine 2006 Sep;24(37-39):6272-81
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2006/01/01
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77 Schauber J et al. Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli. Immunology 2006 Aug;118(4):509-19
Schauber J et al
2006/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
78 Wang S et al. Optimizing immunotherapy in multiple myeloma: Restoring the function of patients" monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ERK MAPK and neutralizing interleukin-6 in progenitor cells. Blood 2006 Dec;108(13):4071-7
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2006/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
79 Kaur D et al. Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression. Allergy 2006 Sep;61(9):1047-53
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80 Ammit AJ et al. Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 2007 Jan;292(1):L199-206
Ammit AJ et al
2007/01/01
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81 Marques-Deak A et al. Measurement of cytokines in sweat patches and plasma in healthy women: validation in a controlled study. J. Immunol. Methods 2006 Aug;315(1-2):99-109
Marques-Deak A et al
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82 Hideshima T et al. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin. Cancer Res. 2006 Oct;12(19):5887-94
Hideshima T et al
2006/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
83 Lisco A et al. Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation. J. Virol. 2007 Jan;81(2):708-17
Lisco A et al
2007/01/01
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84 Petropavlovskaia M et al. Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression. J. Endocrinol. 2006 Oct;191(1):65-81
Petropavlovskaia M et al
2006/01/01
Species: Hamster, Application: Bioassay, Whole Cells PubMed
85 Kato A et al. Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-beta-dependent mechanism. J. Immunol. 2006 Nov;177(10):7164-72
Kato A et al
2006/01/01
Species: Human, Application: Bioassay, Whole Cells PubMed
86 Blaschke F et al. A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor. Circ. Res. 2006 Dec;99(12):e88-99
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87 Orfanos SE et al. Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators. Crit. Care Med. 2007 Jan;35(1):199-206
Orfanos SE et al
2007/01/01
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88 Sugaya M et al. Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J. Immunol. 2006 Dec;177(11):7665-72
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2006/01/01
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89 Johnson LA et al. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J. Exp. Med. 2006 Nov;203(12):2763-77
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2006/01/01
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90 Chattopadhyay S et al. Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells. J. Biol. Chem. 2007 Feb;282(5):3014-26
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91 Schoppet M et al. Osteoprotegerin expression in dendritic cells increases with maturation and is NF-kappaB-dependent. J. Cell. Biochem. 2007 Apr;100(6):1430-9
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92 Rajesh D et al. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells 2007 Feb;25(2):490-9
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2007/01/01
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93 Lin MT et al. IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. Int. J. Cancer 2007 Jun;120(12):2600-8
Lin MT et al
2007/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
94 Ettinger R et al. IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J. Immunol. 2007 Mar;178(5):2872-82
Ettinger R et al
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95 Brechter AB et al. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum. 2007 Mar;56(3):910-23
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96 Kamohara H et al. Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression. Int. J. Oncol. 2007 Apr;30(4):977-83
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97 van Grevenstein WM et al. Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. Dig. Dis. Sci. 2007 Oct;52(10):2775-83
van Grevenstein WM et al
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98 Gross M et al. Beta-2-microglobulin is an androgen-regulated secreted protein elevated in serum of patients with advanced prostate cancer. Clin. Cancer Res. 2007 Apr;13(7):1979-86
Gross M et al
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99 Wolk K et al. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn"s disease. J. Immunol. 2007 May;178(9):5973-81
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100 Kwan WH et al. LPS induces rapid IL-10 release by M-CSF-conditioned tolerogenic dendritic cell precursors. J. Leukoc. Biol. 2007 Jul;82(1):133-41
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204 McFarland BC et al. NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma. PLoS ONE 2013;8(11):e78728
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206 Wong KY et al. Establishment of a bortezomib-resistant Chinese human multiple myeloma cell line: MMLAL. Cancer Cell Int. 2013;13(1):122
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208 Meynard D et al. Inflammation regulates TMPRSS6 expression via STAT5. PLoS ONE 2013;8(12):e82127
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210 Ibrahim SA et al. Syndecan-1 (CD138) modulates triple-negative breast cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling. PLoS ONE 2013;8(12):e85737
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212 Gupta S et al. Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor. J. Biol. Chem. 2014 Mar;289(12):8706-19
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213 Kamat V et al. MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells. Stem Cells 2014 May;32(5):1337-46
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214 Rodin S et al. Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment. Nat Commun 2014;5:3195
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215 Imai F et al. IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation. Endocrinology 2014 Apr;155(4):1436-44
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216 McCutcheon KM et al. Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets. MAbs ;6(2):460-73
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217 Milwid JM et al. Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol. Ther. 2014 May;22(5):999-1007
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218 Prigent L et al. The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation. Eur. J. Immunol. 2014 May;44(5):1330-40
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220 Liu RY et al. JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells. Int. J. Oncol. 2014 May;44(5):1643-51
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221 Di Martino MT et al. In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells. PLoS ONE 2014;9(2):e89659
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222 Umashankar M et al. Antagonistic determinants controlling replicative and latent states of human cytomegalovirus infection. J. Virol. 2014 Jun;88(11):5987-6002
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223 Wiejak J et al. The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs. FEBS Lett. 2014 May;588(9):1556-61
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224 Al-Sadi R et al. Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene. PLoS ONE 2014;9(3):e85345
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225 Zheng Y et al. Direct crosstalk between cancer and osteoblast lineage cells fuels metastatic growth in bone via auto-amplification of IL-6 and RANKL signaling pathways. J. Bone Miner. Res. 2014 Sep;29(9):1938-49
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226 Richter R et al. Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells. Stem Cells Dev. 2014 Aug;23(16):1959-74
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227 Bu Y et al. Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish. J. Cell. Sci. 2014 Jun;127(Pt 12):2761-70
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228 Moreno-Nieves UY et al. NK cells are primed by ANRS MVA(HIV)-infected DCs, via a mechanism involving NKG2D and membrane-bound IL-15, to control HIV-1 infection in CD4+ T cells. Eur. J. Immunol. 2014 Aug;44(8):2370-9
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229 Kongsbak M et al. Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE 2014;9(5):e96695
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230 Kofler DM et al. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J. Clin. Invest. 2014 Jun;124(6):2513-22
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231 Volpe E et al. Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J. Allergy Clin. Immunol. 2014 Aug;134(2):373-81
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232 Horwitz ME et al. Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. J. Clin. Invest. 2014 Jul;124(7):3121-8
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233 Linher-Melville K et al. The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells. BMC Cancer 2014;14:415
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234 Chesnokov V et al. Anti-cancer activity of glucosamine through inhibition of N-linked glycosylation. Cancer Cell Int. 2014;14:45
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235 Mimura N et al. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. Cancer Res. 2014 Aug;74(16):4458-69
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236 Tanaka A et al. Biological activities and phytochemical profiles of extracts from different parts of bamboo (Phyllostachys pubescens). Molecules 2014;19(6):8238-60
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237 Melemedjian OK et al. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain 2014;10:45
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238 Weinkopff T et al. Filarial excretory-secretory products induce human monocytes to produce lymphangiogenic mediators. PLoS Negl Trop Dis 2014 Jul;8(7):e2893
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239 Zhang Q et al. ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex. Mol. Cancer 2014;13:181
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240 Han L et al. The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells. J. Biol. Chem. 2014 Sep;289(37):25546-55
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241 Sehgal K et al. Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk. J. Immunol. 2014 Sep;193(5):2297-305
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242 Bam R et al. Role of Bruton"s tyrosine kinase (BTK) in growth and metastasis of INA6 myeloma cells. Blood Cancer J 2014;4:e234
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243 Yi H et al. A new strategy to deliver synthetic protein drugs: self-reproducible biologics using minicircles. Sci Rep 2014;4:5961
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244 Anderson JL et al. Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors. Mol. Cancer Res. 2014 Dec;12(12):1740-54
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245 Dighe N et al. Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector. PLoS ONE 2014;9(8):e104805
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246 Kwon SM et al. Cross talk with hematopoietic cells regulates the endothelial progenitor cell differentiation of CD34 positive cells. PLoS ONE 2014;9(8):e106310
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247 Normanton M et al. Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion. PLoS ONE 2014;9(9):e106673
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248 Kuchroo P et al. Paracrine factors secreted by umbilical cord-derived mesenchymal stem cells induce angiogenesis in vitro by a VEGF-independent pathway. Stem Cells Dev. 2015 Feb;24(4):437-50
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249 Zhu H et al. miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator. Am. J. Pathol. 2014 Oct;184(10):2828-39
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250 Kuang DM et al. B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets. J. Clin. Invest. 2014 Oct;124(10):4657-67
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251 Davaine JM et al. Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability. PLoS ONE 2014;9(9):e107642
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252 Chinen Y et al. Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma. Cancer Res. 2014 Dec;74(24):7418-29
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253 Lam S et al. Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol. Ther. 2015 Feb;23(2):387-95
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254 Schinnerling K et al. Role of dendritic cells in the pathogenesis of Whipple"s disease. Infect. Immun. 2015 Feb;83(2):482-91
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255 Sobotta MC et al. Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nat. Chem. Biol. 2015 Jan;11(1):64-70
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256 Lee DH et al. HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. Cell. Signal. 2015 Feb;27(2):293-305
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257 Venkatesha VA et al. P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer. Mol. Cancer 2014;13:259
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258 Goedken ER et al. Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol. J. Biol. Chem. 2015 Feb;290(8):4573-89
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259 Sugita S et al. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest. Ophthalmol. Vis. Sci. 2015 Feb;56(2):1051-62
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261 Herov叩 M et al. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. J. Immunol. 2015 Mar;194(5):2330-7
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262 Bhela S et al. Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. J. Immunol. 2015 Mar;194(5):2180-9
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263 Lee JB et al. Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells. Stem Cells 2015 Apr;33(4):1142-52
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264 Elavazhagan S et al. Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity. J. Immunol. 2015 Mar;194(6):2786-95
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265 Bhardwaj R et al. RelB/p50 complexes regulate cytokine-induced YKL-40 expression. J. Immunol. 2015 Mar;194(6):2862-70
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266 Ge R et al. DNA methyl transferase 1 reduces expression of SRD5A2 in the aging adult prostate. Am. J. Pathol. 2015 Mar;185(3):870-82
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267 Gentilini MV et al. Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production. Infect. Immun. 2015 May;83(5):1973-82
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268 Kawada M et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE 2015;10(3):e0119415
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269 Irvin SC et al. Molecular mechanisms linking high dose medroxyprogesterone with HIV-1 risk. PLoS ONE 2015;10(3):e0121135
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270 Patterson SD et al. Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues. PLoS ONE 2015;10(3):e0122149
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271 Camargo JF et al. Impaired T cell responsiveness to interleukin-6 in hematological patients with invasive aspergillosis. PLoS ONE 2015;10(4):e0123171
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272 Aljedai A et al. Potential role of Notch signalling in CD34+ chronic myeloid leukaemia cells: cross-talk between Notch and BCR-ABL. PLoS ONE 2015;10(4):e0123016
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273 Kwofie K et al. Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respir. Res. 2015;16:14
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275 Tolar J et al. Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J. Invest. Dermatol. 2014 May;134(5):1246-54
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276 Pei XY et al. Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells. PLoS ONE 2014;9(3):e89064
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277 Shaw S et al. Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling. MAbs ;6(3):774-82
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278 Zhao Y et al. Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-α, and IL-1β. Am. J. Physiol. Endocrinol. Metab. 2014 Jul;307(2):E186-98
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279 Kastrati I et al. PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres. Oncogene 2015 Apr;34(18):2309-16
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280 Boettcher S et al. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood 2014 Aug;124(9):1393-403
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281 O"Toole A et al. Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive. Br. J. Cancer 2014 Aug;111(5):927-32
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282 Simamura E et al. Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. PLoS ONE 2015;10(4):e0123232
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283 Ilkow CS et al. Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity. Nat. Med. 2015 May;21(5):530-6
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284 Ling Y et al. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J. Exp. Med. 2015 May;212(5):619-31
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285 Park JS et al. p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice. Arthritis Rheum. 2013 Apr;65(4):949-59
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286 Schumacher A et al. Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. J Hematol Oncol 2015;8:64
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287 Yousef S et al. Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma. J Transl Med 2015;13:197
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288 Dong B et al. IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate Cancer. PLoS ONE 2015;10(8):e0134366
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289 Hong SS et al. A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130. J. Immunol. 2015 Jul;195(1):237-45
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290 Gopinathan G et al. Interleukin-6 Stimulates Defective Angiogenesis. Cancer Res. 2015 Aug;75(15):3098-107
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291 Min HK et al. Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-κB. PLoS ONE 2015;10(11):e013
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292 Huston SM et al. Cryptococcus gattii Capsule Blocks Surface Recognition Required for Dendritic Cell Maturation Independent of Internalization and Antigen Processing. J. Immunol. 2016 Feb;196(3):1259-71
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293 Zhong H et al. A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors. Cancer Res. 2016 Jan;76(2):480-90
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294 Koeth RA et al. Protein carbamylation predicts mortality in ESRD. J. Am. Soc. Nephrol. 2013 Apr;24(5):853-61
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295 Srivastava RM et al. Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients. Clin. Cancer Res. 2013 Apr;19(7):1858-72
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296 Mok J et al. Digital microfluidic assay for protein detection. Proc. Natl. Acad. Sci. U.S.A. 2014 Feb;111(6):2110-5
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297 Zhang M et al. Anti-β₂M monoclonal antibodies kill myeloma cells via cell- and complement-mediated cytotoxicity. Int. J. Cancer 2014 Sep;135(5):1132-41
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298 Jensen BM et al. Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells. J. Leukoc. Biol. 2014 Jun;95(6):893-901
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299 Valle Oseguera CA et al. cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells. PLoS ONE 2014;9(2):e88708
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300 Bettini M et al. TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J. Immunol. 2014 Jul;193(2):571-9
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301 Yoon BR et al. Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis. J. Biol. Chem. 2016 Feb;291(8):4048-57
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302 Kandasamy S et al. Differential Effects of Escherichia coli Nissle and Lactobacillus rhamnosus Strain GG on Human Rotavirus Binding, Infection, and B Cell Immunity. J. Immunol. 2016 Feb;196(4):1780-9
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303 Ratajewski M et al. Expression of human gene coding RORγT receptor depends on the Sp2 transcription factor. J. Leukoc. Biol. 2016 Nov;100(5):1213-1223
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304 Pinkenburg O et al. The Human Antimicrobial Protein Bactericidal/Permeability-Increasing Protein (BPI) Inhibits the Infectivity of Influenza A Virus. PLoS ONE 2016;11(6):e0156929
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305 Quick L et al. Jak1-STAT3 Signals Are Essential Effectors of the USP6/TRE17 Oncogene in Tumorigenesis. Cancer Res. 2016 Sep;76(18):5337-47
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306 Doerr N et al. Regulation of Polycystin-1 Function by Calmodulin Binding. PLoS ONE 2016;11(8):e0161525
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307 Titos E et al. Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. J. Immunol. 2016 Oct;197(8):3360-3370
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308 Pinte S et al. Endothelial Cell Activation Is Regulated by Epidermal Growth Factor-like Domain 7 (Egfl7) during Inflammation. J. Biol. Chem. 2016 Nov;291(46):24017-24028
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309 K旦nig C et al. Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha. J. Neurosci. 2016 Sep;36(38):9782-91
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310 Mathis T et al. Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-α. Aging Cell 2016 Sep;
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311 Allen SG et al. Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling. Sci Rep 2016 Dec;6:39190
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312 Pomeroy EJ et al. Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. Oncogene 2017 Jun;36(23):3263-3273
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313 Wang J et al. Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database. Drug Des Devel Ther 2016;10:4091-4100
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314 MikuナB-Pietrasik J et al. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases. Cell Death Dis 2016 Dec;7(12):e2565
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315 テ瑛iテ。s S et al. TGF-β Affects the Differentiation of Human GM-CSF(+) CD4(+) T Cells in an Activation- and Sodium-Dependent Manner. Front Immunol 2016;7:603
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316 Oben KZ et al. Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1). PLoS ONE 2017;12(1):e0169767
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317 Lin C et al. CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling. Oncogene 2017 Jun;36(26):3695-3705
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318 Tsukamoto H et al. Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression. Cancer Res. 2017 May;77(9):2279-2291
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319 He H et al. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3. Sci Rep 2017 Mar;7:43736
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320 Schwartz JA et al. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. J. Immunol. 2017 Apr;198(8):3181-3194
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    Lu SJ et al. CD34+CD38- hematopoietic precursors derived from human embryonic stem cells exhibit an embryonic gene expression pattern. Blood 2004 Jun;103(11):4134-41
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    Suzuki M et al. Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex. Proc. Natl. Acad. Sci. U.S.A. 2004 Mar;101(9):3202-7
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    Terui K et al. Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction. Biochem. J. 2004 May;380(Pt 1):203-9
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    Jeong HJ et al. The effect of acupuncture on proinflammatory cytokine production in patients with chronic headache: a preliminary report. Am. J. Chin. Med. 2003;31(6):945-54
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    Steiner H et al. An autocrine loop for vascular endothelial growth factor is established in prostate cancer cells generated after prolonged treatment with interleukin 6. Eur. J. Cancer 2004 May;40(7):1066-72
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    Wolk K et al. IL-22 increases the innate immunity of tissues. Immunity 2004 Aug;21(2):241-54
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    Kao CY et al. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol. 2004 Sep;173(5):3482-91
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    Ferlazzo G et al. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc. Natl. Acad. Sci. U.S.A. 2004 Nov;101(47):16606-11
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    Mozaffarian D et al. trans fatty acids and systemic inflammation in heart failure. Am. J. Clin. Nutr. 2004 Dec;80(6):1521-5
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    Putz T et al. Monitoring of CD4+ and CD8+ T-cell responses after dendritic cell-based immunotherapy using CFSE dye dilution analysis. J. Clin. Immunol. 2004 Nov;24(6):653-63
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    Mandelin J et al. Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K. J. Rheumatol. 2005 Apr;32(4):713-20
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    Guyot N et al. Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin. Biol. Chem. 2005 Apr;386(4):391-9
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    Holst RM et al. Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery. Acta Obstet Gynecol Scand 200
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    Application: Bioassay, Sample Type: Whole Cells
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