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在庫・価格 : 2024年05月18日 23時29分 現在

商品名 商品コード メーカー 包装 価格 在庫 リスト
6Ckine, Human, Recombinant
データシート
366-6C-025 RSDアールアンドディー システムス
R&D Systems, Inc.
25 μg ¥86,000
(未発注)
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在庫・価格 : 2024年05月18日 23時29分 現在

6Ckine, Human, Recombinant

  • 商品コード:366-6C-025
  • メーカー:RSD
  • 包装:25μg
  • 価格: ¥86,000
  • 在庫:無(未発注)
使用文献
No. 文献情報 備考 参照
1 Grant AJ et al. Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease. Am. J. Pathol. 2002 Apr;160(4):1445-55
Grant AJ et al
2002/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
2 Banas B et al. Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. J. Immunol. 2002 May;168(9):4301-7
Banas B et al
2002/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
3 Jeannin P et al. Outer membrane protein A renders dendritic cells and macrophages responsive to CCL21 and triggers dendritic cell migration to secondary lymphoid organs. Eur. J. Immunol. 2003 Feb;33(2):326-33
Jeannin P et al
2003/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
4 Wang J et al. Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype. Cancer Res. 2004 Mar;64(5):1861-6
Wang J et al
2004/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
5 Sen Y et al. Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology 2004 Jun;112(2):274-89
Sen Y et al
2004/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
6 Zabel BA et al. Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. J. Immunol. 2005 Jan;174(1):244-51
Zabel BA et al
2005/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
7 Badr G et al. HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21. J. Immunol. 2005 Jul;175(1):302-10
Badr G et al
2005/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
8 Balabanian K et al. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J. Biol. Chem. 2005 Oct;280(42):35760-6
Balabanian K et al
2005/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
9 Nakayama T et al. Novel antiviral activity of chemokines. Virology 2006 Jul;350(2):484-92
Nakayama T et al
2006/01/01
Species: viral, Application: Binding Assay, Bioassay, Sample type: HSV-1 virion, Whole Cells PubMed
10 Hirahara K et al. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J. Immunol. 2006 Oct;177(7):4488-94
Hirahara K et al
2006/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
11 Sancho M et al. Expression and function of the chemokine receptor CCR7 in thyroid carcinomas. J. Endocrinol. 2006 Oct;191(1):229-38
Sancho M et al
2006/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
12 Ticchioni M et al. Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a. Oncogene 2007 Nov;26(50):7081-91
Ticchioni M et al
2007/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
13 Hjorthaug HS et al. Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes. Eur. J. Immunol. 2007 Aug;37(8):2326-36
Hjorthaug HS et al
2007/01/01
Species: Human, Application: Bioassay, Sample type: Whole Cells PubMed
14 Yang BG et al. Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules: its implications in lymphocyte trafficking. J. Immunol. 2007 Oct;179(7):4376-82
Yang BG et al
2007/01/01
Species: Mouse, Application: Bioassay, Biacore binding study, ELISA capture, Sample type: Whole Cells, Extracellular matricies, BSA, Collagen IV, Fibronectin, Laminin 1 PubMed
15 Stachowiak AN et al. Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration. J Biomed Mater Res A 2008 Jun;85(3):815-28
Stachowiak AN et al
2008/01/01
Application: scaffold loading, Protein scaffold PubMed
16 Huang Y et al. The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood 2008 Jul;112(1):111-9
Huang Y et al
2008/01/01
Species: Human, Application: Bioassay, Whole Cells PubMed
17 Hartmann TN et al. A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J. Leukoc. Biol. 2008 Oct;84(4):1130-40
Hartmann TN et al
2008/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
18 Cagigi A et al. Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood 2008 Dec;112(12):4401-10
Cagigi A et al
2008/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
19 Ehlin-Henriksson B et al. Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection. Immunology 2009 Aug;127(4):549-57
Ehlin-Henriksson B et al
2009/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
20 Dam奪s JK et al. Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication. Clin. Exp. Immunol. 2009 Sep;157(3):400-7
Dam奪s JK et al
2009/01/01
Application: Media Supplement, Sample Type: Whole Cells PubMed
21 Berrih-Aknin S et al. CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. Ann. Neurol. 2009 Oct;66(4):521-31
Berrih-Aknin S et al
2009/01/01
Application: Bioassay,ELISA Standard, Sample Type: Homogenized Tissue,Whole Cells PubMed
22 Kriehuber E et al. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J. Exp. Med. 2001 Sep;194(6):797-808
Kriehuber E et al
2001/01/01
Application: ELISA Standard, Sample Type: Cell Supernates PubMed
23 Wilson TR et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012 Jul;487(7408):505-9
Wilson TR et al
2012/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
24 Curiel TJ et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004 Sep;10(9):942-9
Curiel TJ et al
2004/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
25 Da Silva DM et al. Suppression of Langerhans cell activation is conserved amongst human papillomavirus α and β genotypes, but not a µ genotype. Virology 2014 Mar;452-453:279-86
Da Silva DM et al
2014/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
26 Deng Y et al. Umbilical cord-derived mesenchymal stem cells instruct dendritic cells to acquire tolerogenic phenotypes through the IL-6-mediated upregulation of SOCS1. Stem Cells Dev. 2014 Sep;23(17):2080-92
Deng Y et al
2014/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
27 Irino T et al. CC-Chemokine receptor CCR7: a key molecule for lymph node metastasis in esophageal squamous cell carcinoma. BMC Cancer 2014;14:291
Irino T et al
2014/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
28 Xu Y et al. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. Blood 2014 Jun;123(24):3750-9
Xu Y et al
2014/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
29 Borgman KJ et al. Priming by chemokines restricts lateral mobility of the adhesion receptor LFA-1 and restores adhesion to ICAM-1 nano-aggregates on human mature dendritic cells. PLoS ONE 2014;9(6):e99589
Borgman KJ et al
2014/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
30 Till KJ et al. Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells. J. Immunol. 2015 Mar;194(5):2439
Till KJ et al
2015/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
31 Tutunea-Fatan E et al. The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis. Mol. Cancer 2015;14:35
Tutunea-Fatan E et al
2015/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
32 Yu Q et al. Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. PLoS ONE 2015;10(3):e0120855
Yu Q et al
2015/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
33 Swaims-Kohlmeier A et al. Progesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential. J. Immunol. 2016 Jul;197(1):368-76
Swaims-Kohlmeier A et al
2016/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
34 Van den Bergh JMJ et al. Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use. J Immunol Res 2017;2017:1975902
Van den Bergh JMJ et al
2017/01/01
Application: Bioassay, Sample Type: Whole Cells PubMed
  • No.: 1
  • 文献情報:
    Grant AJ et al. Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease. Am. J. Pathol. 2002 Apr;160(4):1445-55
    Grant AJ et al
    2002/01/01
  • 備考:
    Species: Human, Application: Bioassay, Sample type: Whole Cells
  • 参照:
    PubMed
  • No.: 2
  • 文献情報:
    Banas B et al. Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. J. Immunol. 2002 May;168(9):4301-7
    Banas B et al
    2002/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 3
  • 文献情報:
    Jeannin P et al. Outer membrane protein A renders dendritic cells and macrophages responsive to CCL21 and triggers dendritic cell migration to secondary lymphoid organs. Eur. J. Immunol. 2003 Feb;33(2):326-33
    Jeannin P et al
    2003/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 4
  • 文献情報:
    Wang J et al. Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype. Cancer Res. 2004 Mar;64(5):1861-6
    Wang J et al
    2004/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 5
  • 文献情報:
    Sen Y et al. Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology 2004 Jun;112(2):274-89
    Sen Y et al
    2004/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 6
  • 文献情報:
    Zabel BA et al. Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. J. Immunol. 2005 Jan;174(1):244-51
    Zabel BA et al
    2005/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 7
  • 文献情報:
    Badr G et al. HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21. J. Immunol. 2005 Jul;175(1):302-10
    Badr G et al
    2005/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 8
  • 文献情報:
    Balabanian K et al. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J. Biol. Chem. 2005 Oct;280(42):35760-6
    Balabanian K et al
    2005/01/01
  • 備考:
    Species: Human, Application: Bioassay, Sample type: Whole Cells
  • 参照:
    PubMed
  • No.: 9
  • 文献情報:
    Nakayama T et al. Novel antiviral activity of chemokines. Virology 2006 Jul;350(2):484-92
    Nakayama T et al
    2006/01/01
  • 備考:
    Species: viral, Application: Binding Assay, Bioassay, Sample type: HSV-1 virion, Whole Cells
  • 参照:
    PubMed
  • No.: 10
  • 文献情報:
    Hirahara K et al. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J. Immunol. 2006 Oct;177(7):4488-94
    Hirahara K et al
    2006/01/01
  • 備考:
    Species: Human, Application: Bioassay, Sample type: Whole Cells
  • 参照:
    PubMed
  • No.: 11
  • 文献情報:
    Sancho M et al. Expression and function of the chemokine receptor CCR7 in thyroid carcinomas. J. Endocrinol. 2006 Oct;191(1):229-38
    Sancho M et al
    2006/01/01
  • 備考:
    Species: Human, Application: Bioassay, Sample type: Whole Cells
  • 参照:
    PubMed
  • No.: 12
  • 文献情報:
    Ticchioni M et al. Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a. Oncogene 2007 Nov;26(50):7081-91
    Ticchioni M et al
    2007/01/01
  • 備考:
    Species: Human, Application: Bioassay, Sample type: Whole Cells
  • 参照:
    PubMed
  • No.: 13
  • 文献情報:
    Hjorthaug HS et al. Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes. Eur. J. Immunol. 2007 Aug;37(8):2326-36
    Hjorthaug HS et al
    2007/01/01
  • 備考:
    Species: Human, Application: Bioassay, Sample type: Whole Cells
  • 参照:
    PubMed
  • No.: 14
  • 文献情報:
    Yang BG et al. Binding of lymphoid chemokines to collagen IV that accumulates in the basal lamina of high endothelial venules: its implications in lymphocyte trafficking. J. Immunol. 2007 Oct;179(7):4376-82
    Yang BG et al
    2007/01/01
  • 備考:
    Species: Mouse, Application: Bioassay, Biacore binding study, ELISA capture, Sample type: Whole Cells, Extracellular matricies, BSA, Collagen IV, Fibronectin, Laminin 1
  • 参照:
    PubMed
  • No.: 15
  • 文献情報:
    Stachowiak AN et al. Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration. J Biomed Mater Res A 2008 Jun;85(3):815-28
    Stachowiak AN et al
    2008/01/01
  • 備考:
    Application: scaffold loading, Protein scaffold
  • 参照:
    PubMed
  • No.: 16
  • 文献情報:
    Huang Y et al. The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood 2008 Jul;112(1):111-9
    Huang Y et al
    2008/01/01
  • 備考:
    Species: Human, Application: Bioassay, Whole Cells
  • 参照:
    PubMed
  • No.: 17
  • 文献情報:
    Hartmann TN et al. A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J. Leukoc. Biol. 2008 Oct;84(4):1130-40
    Hartmann TN et al
    2008/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 18
  • 文献情報:
    Cagigi A et al. Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood 2008 Dec;112(12):4401-10
    Cagigi A et al
    2008/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 19
  • 文献情報:
    Ehlin-Henriksson B et al. Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection. Immunology 2009 Aug;127(4):549-57
    Ehlin-Henriksson B et al
    2009/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 20
  • 文献情報:
    Dam奪s JK et al. Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication. Clin. Exp. Immunol. 2009 Sep;157(3):400-7
    Dam奪s JK et al
    2009/01/01
  • 備考:
    Application: Media Supplement, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 21
  • 文献情報:
    Berrih-Aknin S et al. CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. Ann. Neurol. 2009 Oct;66(4):521-31
    Berrih-Aknin S et al
    2009/01/01
  • 備考:
    Application: Bioassay,ELISA Standard, Sample Type: Homogenized Tissue,Whole Cells
  • 参照:
    PubMed
  • No.: 22
  • 文献情報:
    Kriehuber E et al. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J. Exp. Med. 2001 Sep;194(6):797-808
    Kriehuber E et al
    2001/01/01
  • 備考:
    Application: ELISA Standard, Sample Type: Cell Supernates
  • 参照:
    PubMed
  • No.: 23
  • 文献情報:
    Wilson TR et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012 Jul;487(7408):505-9
    Wilson TR et al
    2012/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 24
  • 文献情報:
    Curiel TJ et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004 Sep;10(9):942-9
    Curiel TJ et al
    2004/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 25
  • 文献情報:
    Da Silva DM et al. Suppression of Langerhans cell activation is conserved amongst human papillomavirus α and β genotypes, but not a µ genotype. Virology 2014 Mar;452-453:279-86
    Da Silva DM et al
    2014/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 26
  • 文献情報:
    Deng Y et al. Umbilical cord-derived mesenchymal stem cells instruct dendritic cells to acquire tolerogenic phenotypes through the IL-6-mediated upregulation of SOCS1. Stem Cells Dev. 2014 Sep;23(17):2080-92
    Deng Y et al
    2014/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 27
  • 文献情報:
    Irino T et al. CC-Chemokine receptor CCR7: a key molecule for lymph node metastasis in esophageal squamous cell carcinoma. BMC Cancer 2014;14:291
    Irino T et al
    2014/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 28
  • 文献情報:
    Xu Y et al. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. Blood 2014 Jun;123(24):3750-9
    Xu Y et al
    2014/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 29
  • 文献情報:
    Borgman KJ et al. Priming by chemokines restricts lateral mobility of the adhesion receptor LFA-1 and restores adhesion to ICAM-1 nano-aggregates on human mature dendritic cells. PLoS ONE 2014;9(6):e99589
    Borgman KJ et al
    2014/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 30
  • 文献情報:
    Till KJ et al. Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells. J. Immunol. 2015 Mar;194(5):2439
    Till KJ et al
    2015/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 31
  • 文献情報:
    Tutunea-Fatan E et al. The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis. Mol. Cancer 2015;14:35
    Tutunea-Fatan E et al
    2015/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 32
  • 文献情報:
    Yu Q et al. Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. PLoS ONE 2015;10(3):e0120855
    Yu Q et al
    2015/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 33
  • 文献情報:
    Swaims-Kohlmeier A et al. Progesterone Levels Associate with a Novel Population of CCR5+CD38+ CD4 T Cells Resident in the Genital Mucosa with Lymphoid Trafficking Potential. J. Immunol. 2016 Jul;197(1):368-76
    Swaims-Kohlmeier A et al
    2016/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed
  • No.: 34
  • 文献情報:
    Van den Bergh JMJ et al. Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use. J Immunol Res 2017;2017:1975902
    Van den Bergh JMJ et al
    2017/01/01
  • 備考:
    Application: Bioassay, Sample Type: Whole Cells
  • 参照:
    PubMed