Anti-IKK beta, Mouse-Mono(10AG2)

データシート

• 商品コード：NB100-56509
• メーカー：NOV
• 包装：0.1mg
• 価格： ¥96,000
• 在庫：無(未発注)

マイリストに追加 マイリストに追加済

• No.： 1
• 文献情報：
  Santos M et al. Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis. J. Biol. Chem. 2003 Apr;278(15):13422-30
  Santos M et al
  2003/01/01
  
• 備考：
  
• 参照：
  

• No.： 2
• 文献情報：
  Anto RJ et al. Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis 2002 Sep;23(9):1511-8
  Anto RJ et al
  2002/01/01
  
• 備考：
  
• 参照：
  

• No.： 3
• 文献情報：
  Ashikawa K et al. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J. Immunol. 2002 Dec;169(11):6490-7
  Ashikawa K et al
  2002/01/01
  
• 備考：
  
• 参照：
  

• No.： 4
• 文献情報：
  Page A et al. IKKβ overexpression leads to pathologic lesions in stratified epithelia and exocrine glands and to tumoral transformation of oral epithelia. Mol. Cancer Res. 2011 Oct;9(10):1329-38
  Page A et al
  2011/01/01
  
• 備考：
  
• 参照：
  

• No.： 5
• 文献情報：
  Majumdar S et al. Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types. Oncogene 2003 Feb;22(8):1206-18
  Majumdar S et al
  2003/01/01
  
• 備考：
  
• 参照：
  

• No.： 6
• 文献情報：
  Majumdar S et al. Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. J. Immunol. 2001 Sep;167(5):2911-20
  Majumdar S et al
  2001/01/01
  
• 備考：
  
• 参照：
  

• No.： 7
• 文献情報：
  Shishodia S et al. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synt
  Shishodia S et al
  2004/01/01
  
• 備考：
  
• 参照：
  

• No.： 8
• 文献情報：
  Takada Y et al. Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis. J. Biol.
  Takada Y et al
  2004/01/01
  
• 備考：
  
• 参照：
  

• No.： 9
• 文献情報：
  Takada Y et al. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J
  Takada Y et al
  2004/01/01
  
• 備考：
  
• 参照：
  

• No.： 10
• 文献情報：
  Takada Y et al. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J. Biol. Chem. 20
  Takada Y et al
  2004/01/01
  
• 備考：
  
• 参照：
  

• No.： 11
• 文献情報：
  Ichikawa H et al. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J. Immunol. 2005 Jun;174(11):7383-92
  Ichikawa H et al
  2005/01/01
  
• 備考：
  
• 参照：
  

• No.： 12
• 文献情報：
  Takada Y et al. Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J. Biol. Chem. 2004 Sep;279(38):39541-54
  Takada Y et al
  2004/01/01
  
• 備考：
  
• 参照：
  

• No.： 13
• 文献情報：
  Shishodia S et al. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem. Pharmacol. 2005 Sep;70(5):700-13
  Shishodia S et al
  2005/01/01
  
• 備考：
  
• 参照：
  

• No.： 14
• 文献情報：
  Jackson-Bernitsas DG et al. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene 2007 Mar;26(10):1385-97
  Jackson-Bernitsas DG et al
  2007/01/01
  
• 備考：
  
• 参照：
  

• No.： 15
• 文献情報：
  Miller BS et al. Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J. Biol. Chem. 2001 Sep;276(39):36320-6
  Miller BS et al
  2001/01/01
  
• 備考：
  
• 参照：
  

• No.： 16
• 文献情報：
  Ichikawa H et al. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin. Cancer Res. 2006 Jan;12(2):662-8
  Ichikawa H et al
  2006/01/01
  
• 備考：
  
• 参照：
  

• No.： 17
• 文献情報：
  Kasinski AL et al. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol. Pharmacol. 2008 Sep;74(3):654-61
  Kasinski AL et al
  2008/01/01
  
• 備考：
  
• 参照：
  

• No.： 18
• 文献情報：
  Manna SK et al. Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J. Immunol. 2000 Nov;165(10):5962-9
  Manna SK et al
  2000/01/01
  
• 備考：
  
• 参照：
  

• No.： 19
• 文献情報：
  Majumdar S et al. Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J. Immunol. 2002 Mar;168(6):2644-51
  Majumdar S et al
  2002/01/01
  
• 備考：
  
• 参照：
  

• No.： 20
• 文献情報：
  Luedde T et al. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J. Clin. Invest. 2005 Apr;115(4):849-59
  Luedde T et al
  2005/01/01
  
• 備考：
  
• 参照：
  

• No.： 21
• 文献情報：
  Shishodia S et al. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J. Biol. Chem. 2004 Nov;279(45):47148-58
  Shishodia S et al
  2004/01/01
  
• 備考：
  
• 参照：
  

• No.： 22
• 文献情報：
  Jin HS et al. cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation. Cancer Res. 2009 Mar;69(5):1782-91
  Jin HS et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 23
• 文献情報：
  Huang J et al. HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB. J. Biol. Chem. 2009 Mar;284(10):6208-17
  Huang J et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 24
• 文献情報：
  Sethi G et al. Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J. Biol. Chem. 2006 Aug;281(33):23425-35
  Sethi G et al
  2006/01/01
  
• 備考：
  
• 参照：
  

• No.： 25
• 文献情報：
  Vunta H et al. The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. J. Biol. Chem. 2007 Jun;282(25):17964-73
  Vunta H et al
  2007/01/01
  
• 備考：
  
• 参照：
  

• No.： 26
• 文献情報：
  Lamothe B et al. TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation. Biochem. Biophys. Res. Commun. 2007 Aug;359(4):1044-9
  Lamothe B et al
  2007/01/01
  
• 備考：
  
• 参照：
  

• No.： 27
• 文献情報：
  Delhase M et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc. Natl. Acad. Sci. U.S.A. 2012 Jan;109(4):E177-86
  Delhase M et al
  2012/01/01
  
• 備考：
  
• 参照：
  

• No.： 28
• 文献情報：
  Beraza N et al. Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury. Gastroenterology 2007 Jun;132(7):2504-17
  Beraza N et al
  2007/01/01
  
• 備考：
  
• 参照：
  

• No.： 29
• 文献情報：
  Herrmann O et al. IKK mediates ischemia-induced neuronal death. Nat. Med. 2005 Dec;11(12):1322-9
  Herrmann O et al
  2005/01/01
  
• 備考：
  
• 参照：
  

• No.： 30
• 文献情報：
  Phromnoi K et al. A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic age
  Phromnoi K et al
  2011/01/01
  
• 備考：
  
• 参照：
  

• No.： 31
• 文献情報：
  Shishodia S et al. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products. Cancer Res. 2005 Oct;65(20):
  Shishodia S et al
  2005/01/01
  
• 備考：
  
• 参照：
  

• No.： 32
• 文献情報：
  Takada Y et al. Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation. J. Biol. Chem. 2006 Mar;281(9):5612-22
  Takada Y et al
  2006/01/01
  
• 備考：
  
• 参照：
  

• No.： 33
• 文献情報：
  Nenci A et al. Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. Hum. Mol. Genet. 2006 Feb;15(4):531-42
  Nenci A et al
  2006/01/01
  
• 備考：
  
• 参照：
  

• No.： 34
• 文献情報：
  Bimonte S et al. Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer. Biomed Res Int 2013;2013:810423
  Bimonte S et al
  2013/01/01
  
• 備考：
  
• 参照：
  

• No.： 35
• 文献情報：
  Ren T et al. HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains. Oncogene 2013 Dec;
  Ren T et al
  2013/01/01
  
• 備考：
  
• 参照：
  

• No.： 36
• 文献情報：
  Sandur SK et al. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine
  Sandur SK et al
  2006/01/01
  
• 備考：
  Applications: WB
• 参照：
  

• No.： 37
• 文献情報：
  Kunnumakkara AB et al. Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis. Mol. Cancer T
  Kunnumakkara AB et al
  2008/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 38
• 文献情報：
  Pandey MK et al. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Res. 2008 Jul;68(13):5370-9
  Pandey MK et al
  2008/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 39
• 文献情報：
  Buhrmann C et al. Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells. J. Biol. Chem. 2014 Aug;289(32):22048-62
  Buhrmann C et al
  2014/01/01
  
• 備考：
  Species: Human, Applications: IP, WB
• 参照：
  

• No.： 40
• 文献情報：
  Leis H et al. Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol 3-Kinase Signaling Pathway. Mol. Endocrinol. 2004 Feb;18(2):303-11
  Leis H et al
  2004/01/01
  
• 備考：
  Species: Mouse, Applications: WB
• 参照：
  

• No.： 41
• 文献情報：
  Breuer R et al. The protein phosphatase 2A regulatory subunit B56γ mediates suppression of T cell receptor (TCR)-induced nuclear factor-κB (NF-κB) activity. J. Biol. Chem. 2014 May;289(21):14996-5004
  Breuer R et al
  2014/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 42
• 文献情報：
  Gray CM et al. Noncanonical NF-κB signaling is limited by classical NF-κB activity. Sci Signal 2014 Feb;7(311):ra13
  Gray CM et al
  2014/01/01
  
• 備考：
  Species: Mouse, Applications: WB
• 参照：
  

• No.： 43
• 文献情報：
  Paul S et al. T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome. Sci Signal 2014 May;7(325):ra45
  Paul S et al
  2014/01/01
  
• 備考：
  Species: Mouse, Applications: ICC/IF
• 参照：
  

• No.： 44
• 文献情報：
  Das U et al. Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model. PLoS ONE 2014;9(5):e97599
  Das U et al
  2014/01/01
  
• 備考：
  Species: Mouse, Applications: WB
• 参照：
  

• No.： 45
• 文献情報：
  Leis H et al. Deletion of the N-terminus of IKKgamma induces apoptosis in keratinocytes and impairs the AKT/PTEN signaling pathway. Exp. Cell Res. 2007 Feb;313(4):742-52
  Leis H et al
  2007/01/01
  
• 備考：
  Species: Mouse
• 参照：
  

• No.： 46
• 文献情報：
  Harikumar KB et al. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol. Pharmacol. 2010 May;77(5):818-27
  Harikumar KB et al
  2010/01/01
  
• 備考：
  
• 参照：
  

• No.： 47
• 文献情報：
  Koch KS et al. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem. Biophys. Res. Commun. 2009 Mar;380(2):349-54
  Koch KS et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 48
• 文献情報：
  De S et al. Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling. J. Biol. Chem. 2018 Sep;293(39):15208-15220
  De S et al
  2018/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 49
• 文献情報：
  Kirkley KS et al. Spontaneous Development of Cutaneous Squamous Cell Carcinoma in Mice with Cell-specific Deletion of Inhibitor of κB Kinase 2. Comp. Med. 2017 Oct;67(5):407-415
  Kirkley KS et al
  2017/01/01
  
• 備考：
  Species: Mouse, Applications: IHC-P
• 参照：
  

• No.： 50
• 文献情報：
  Abdi K et al. Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun 2018 04;9(1):1655
  Abdi K et al
  2018/01/01
  
• 備考：
  Species: Mouse, Applications:
• 参照：
  

• No.： 51
• 文献情報：
  Liu J et al. Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction. Cell 2016 11;167(4):1052-1066.e18
  Liu J et al
  2016/01/01
  
• 備考：
  Species: Human, Applications:
• 参照：
  

• No.： 52
• 文献情報：
  Cleary MM et al. NFκB signaling in alveolar rhabdomyosarcoma. Dis Model Mech 2017 Sep;10(9):1109-1115
  Cleary MM et al
  2017/01/01
  
• 備考：
  Species: Mouse, Applications: WB
• 参照：
  

• No.： 53
• 文献情報：
  Best KT et al. NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival. Sci Signal 2020 11;13(658)
  Best KT et al
  2020/01/01
  
• 備考：
  
• 参照：
  

• No.： 54
• 文献情報：
  Reid MA et al. IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev. 2016 08;30(16):1837-51
  Reid MA et al
  2016/01/01
  
• 備考：
  
• 参照：
  

• No.： 55
• 文献情報：
  Karim K et al. Marantodes pumilum Var Alata (Kacip Fatimah) ameliorates derangement in RANK/RANKL/OPG pathway and reduces inflammation and oxidative stress in the bone of estrogen-deficient female rats with type-2 diabetes. Phytomedicine 2021 Oct;91:15367
  Karim K et al
  2021/01/01
  
• 備考：
  Applications: IHC
• 参照：