Anti-HIF Prolyl Hydroxylase 2, Rabbit-Poly <Anti-PHD2> <Anti-EGLN1>

データシート※最新のデータシートでない場合があります

• 商品コード：NB100-137SS
• メーカー：NOV
• 包装：25μl
• 本製品は取扱中止になりました

マイリストに追加 マイリストに追加済

• No.： 1
• 文献情報：
  Asikainen TM et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc. Natl. Acad. Sci. U.S.A. 2005 Jul;102(29):10212-7
  Asikainen TM et al
  2005/01/01
  
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• No.： 2
• 文献情報：
  Jokilehto T et al. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Clin. Cancer Res. 2006 Feb;12(4):1080-7
  Jokilehto T et al
  2006/01/01
  
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• No.： 3
• 文献情報：
  Elvidge GP et al. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J. Biol. Chem. 2006 Jun;281(22):15215-26
  Elvidge GP et al
  2006/01/01
  
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• No.： 4
• 文献情報：
  Ietta F et al. Dynamic HIF1A regulation during human placental development. Biol. Reprod. 2006 Jul;75(1):112-21
  Ietta F et al
  2006/01/01
  
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• No.： 5
• 文献情報：
  McMahon S et al. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J. Biol. Chem. 2006 Aug;281(34):24171-81
  McMahon S et al
  2006/01/01
  
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• No.： 6
• 文献情報：
  Barth S et al. The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol. Cell. Biol. 2007 May;27(10):3758-68
  Barth S et al
  2007/01/01
  
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• No.： 7
• 文献情報：
  Li J et al. Prolyl-4-hydroxylase Domain Protein 2 Controls NF-&#x3BA;B/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus. J. Biol. Chem. 2015 Mar;290(11):7195-207
  Li J et al
  2015/01/01
  
• 備考：
  Species: Rat, Applications: ICC/IF
• 参照：
  

• No.： 8
• 文献情報：
  Vogler M et al. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch. 2015 Jan;
  Vogler M et al
  2015/01/01
  
• 備考：
  Species: Mouse, Applications: IHC-P
• 参照：
  

• No.： 9
• 文献情報：
  Sun W et al. Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-&#x3B1;. Cell Death Dis 2014;5:e1322
  Sun W et al
  2014/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 10
• 文献情報：
  Lindholm ME et al. Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2014 Aug;307(3):R248-55
  Lindholm ME et al
  2014/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 11
• 文献情報：
  Fujita N et al. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1&#x3B1; activity in hypoxia.
  Fujita N et al
  2012/01/01
  
• 備考：
  Species: Human, Rat, Applications: ICC/IF, WB
• 参照：
  

• No.： 12
• 文献情報：
  Wu YL et al. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J. Cell. Sci. 2006 Jul;119(Pt 13):2797-806
  Wu YL et al
  2006/01/01
  
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  Applications:
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• No.： 13
• 文献情報：
  Manalo DJ et al. Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1&#x3B1;) and induces hepcidin (Hamp) in rat kidney. Biochem. Biophys. Res. Commun. 2011 Dec;416(3-4):421-6
  Manalo DJ et al
  2011/01/01
  
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• No.： 14
• 文献情報：
  Vogel S et al. Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation. J. Biol. Chem. 2010 Oct;285(44):33756-63
  Vogel S et al
  2010/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 15
• 文献情報：
  Nandal A et al. Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2. Cell Metab. 2011 Nov;14(5):647-57
  Nandal A et al
  2011/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 16
• 文献情報：
  Schultz K et al. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol. 2009 Jun;296(6):L921-7
  Schultz K et al
  2009/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 17
• 文献情報：
  Caprara V et al. Endothelin-1 regulates hypoxia-inducible factor-1&#x3B1; and -2&#x3B1; stability through prolyl hydroxylase domain 2 inhibition in human lymphatic endothelial cells. Life Sci. 2014 Nov;118(2):185-90
  Caprara V et al
  2014/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 18
• 文献情報：
  Wottawa M et al. Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-&#x3B2;1 processing. Int. J. Cancer 2013 Jun;132(12):2787-98
  Wottawa M et al
  2013/01/01
  
• 備考：
  Species: Human, Applications: WB, IHC
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• No.： 19
• 文献情報：
  Luukkaa M et al. Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck. Int. J. Radiat. Biol. 2009;85(10):900-8
  Luukkaa M et al
  2009/01/01
  
• 備考：
  Species: Human, Applications: IHC-P
• 参照：
  

• No.： 20
• 文献情報：
  Tan JT et al. High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1&#x3B1;. FASEB J. 2014 Jan;28(1):206-17
  Tan JT et al
  2014/01/01
  
• 備考：
  Species: Human, Applications: WB
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• No.： 21
• 文献情報：
  Niecknig H et al. Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. Free Radic. Res. 2012 Jun;46(6):705-17
  Niecknig H et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 22
• 文献情報：
  Han WQ et al. Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. Biochim. Biophys. Acta 2013 Jun;1833(6):1454-62
  Han WQ et al
  2013/01/01
  
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• No.： 23
• 文献情報：
  Rawluszko AA et al. Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer. BMC Cancer 2013;13:526
  Rawluszko AA et al
  2013/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 24
• 文献情報：
  Botting KJ et al. Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes. J Am Heart Assoc 2014 Aug;3(4)
  Botting KJ et al
  2014/01/01
  
• 備考：
  Applications: WB
• 参照：
  

• No.： 25
• 文献情報：
  Bordoli MR et al. Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis. Oncogene 2011 Feb;30(5):548-60
  Bordoli MR et al
  2011/01/01
  
• 備考：
  Species: Human, Applications: IHC-P
• 参照：
  

• No.： 26
• 文献情報：
  Baek JH et al. Induction of hypoxia inducible factor (HIF-1&#x3B1;) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochim. Biophys. Acta ;1809(4-6):262-8
  Baek JH et al
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 27
• 文献情報：
  Aprelikova O et al. Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. Cancer Res. 2009 Jan;69(2):616-24
  Aprelikova O et al
  2009/01/01
  
• 備考：
  Species: Human, Applications: WB, IP, ICC/IF
• 参照：
  

• No.： 28
• 文献情報：
  Jokilehto T et al. Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth. Exp. Cell Res. 2010 Apr;316(7):1169-78
  Jokilehto T et al
  2010/01/01
  
• 備考：
  Species: Human, Applications: IHC, WB
• 参照：
  

• No.： 29
• 文献情報：
  Persano L et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1&#x3B1; stability and MGMT expression. Cell Death Dis 2012;3:e412
  Persano L et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 30
• 文献情報：
  Rantanen K et al. Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation. Mol. Biol. Cell 2008 May;19(5):2231-40
  Rantanen K et al
  2008/01/01
  
• 備考：
  Species: Human, Applications: ICC/IF
• 参照：
  

• No.： 31
• 文献情報：
  Wang Z et al. Hypoxia-inducible factor-1&#x3B1; contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney Int. 2011 Feb;79(3):300-10
  Wang Z et al
  2011/01/01
  
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  Applications:
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• No.： 32
• 文献情報：
  Yin L et al. Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia. J. Biol. Chem. 2007 Jan;282(1):257-66
  Yin L et al
  2007/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 33
• 文献情報：
  Wollenick K et al. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res. 2012 Mar;40(5):1928-43
  Wollenick K et al
  2012/01/01
  
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• No.： 34
• 文献情報：
  Zhu Q et al. Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats. Am. J. Hypertens. 2014 Jan;27(1):107-13
  Zhu Q et al
  2014/01/01
  
• 備考：
  Species: Rat, Applications: WB
• 参照：
  

• No.： 35
• 文献情報：
  Brockmeier U et al. The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS ONE 2011;6(4):e19151
  Brockmeier U et al
  2011/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 36
• 文献情報：
  Place TL et al. Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition. PLoS ONE 2013;8(12):e83021
  Place TL et al
  2013/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 37
• 文献情報：
  Kaufmann MR et al. Dysregulation of hypoxia-inducible factor by presenilin/&#x3B3;-secretase loss-of-function mutations. J. Neurosci. 2013 Jan;33(5):1915-26
  Kaufmann MR et al
  2013/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 38
• 文献情報：
  Li N et al. Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. Am. J. Physiol. Renal Physiol. 2007 Jan;292(1):F207-16
  Li N et al
  2007/01/01
  
• 備考：
  Species: Rat, Applications: WB, IHC-P
• 参照：
  

• No.： 39
• 文献情報：
  Henze AT et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun 2014;5:5582
  Henze AT et al
  2014/01/01
  
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  Applications:
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• No.： 40
• 文献情報：
  H旦gel H et al. Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells. PLoS ONE 2011;6(11):e27112
  H旦gel H et al
  2011/01/01
  
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  Applications:
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• No.： 41
• 文献情報：
  Hsiao HW et al. Deltex1 antagonizes HIF-1&#x3B1; and sustains the stability of regulatory T cells in vivo. Nat Commun 2015;6:6353
  Hsiao HW et al
  2015/01/01
  
• 備考：
  Species: Human, Mouse, Applications: WB
• 参照：
  

• No.： 42
• 文献情報：
  Verstraete M et al. Investigation of possible endogenous hypoxia markers in colorectal cancer. Int. J. Radiat. Biol. 2012 Aug;
  Verstraete M et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: IHC
• 参照：
  

• No.： 43
• 文献情報：
  De Saedeleer CJ et al. Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells. PLoS ONE 2012;7(10):e46571
  De Saedeleer CJ et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 44
• 文献情報：
  Luo W et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011 May;145(5):732-44
  Luo W et al
  2011/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 45
• 文献情報：
  Br旦kers N et al. Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes. Cancer Sci. 2010 Jan;101(1):129-36
  Br旦kers N et al
  2010/01/01
  
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